Expression of a naturally occurring angiotensin AT 1 receptor cleavage fragment elicits caspase-activation and apoptosis

American Journal of Physiology - Cell Physiology

Volumn 301, Issue 5, 2011, Pages

  Cook, Julia L ^a   Singh, Akannsha ^a   deHaro, Dawn ^a   Alam, Jawed ^a   Re, Richard N ^a  

^a OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

Angiotensin II type I receptor; Cardiomyoblast; DNA ladder; Poly(ADP ribose) polymerase; Terminal deoxynucleotidyl transferasemediated dUTP nick end labeling

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CASPASE; CASPASE 3; GLYCINE; LEUCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; AORTA MEDIA; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CARCINOMA CELL; CELL NUCLEUS; CELL STRAIN; CHO CELL; ENZYME ACTIVATION; FEMALE; FRAGMENTATION REACTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CASPASES; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; HUMANS; IN SITU NICK-END LABELING; MOLECULAR SEQUENCE DATA; POLY(ADP-RIBOSE) POLYMERASES; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; UP-REGULATION;

RATTUS;

EID: 80054917663     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00040.2011     Document Type: Article

References (40)

1. Barten DM, Albright CF. Therapeutic strategies for Alzheimer's disease. Mol Neurobiol 37: 171-186, 2008.
2. Bertuccio CA, Chapin HC, Cai Y, Mistry K, Chauvet V, Somlo S, Caplan MJ. Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression. J Biol Chem 284: 21011-21026, 2009.
3. Cook JL, Mills SJ, Naquin R, Alam J, Re RN. Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation. J Mol Cell Cardiol 40: 696-707, 2006.
4. Cook JL, Mills SJ, Naquin RT, Alam J, Re RN. Cleavage of the angiotensin II type 1 receptor and nuclear accumulation of the cytoplasmic carboxy-terminal fragment. Am J Physiol Cell Physiol 292: C1313-C1322, 2007.
5. Cook JL, Re R, Alam J, Hart M, Zhang Z. Intracellular angiotensin II fusion protein alters AT1 receptor fusion protein distribution and activates CREB. J Mol Cell Cardiol 36: 75-90, 2004.
6. Fabris B, Candido R, Bortoletto M, Toffoli B, Bernardi S, Stebel M, Bardelli M, Zentilin L, Giacca M, Carretta R. Stimulation of cardiac apoptosis in ovariectomized hypertensive rats: potential role of the reninangiotensin system. J Hypertens 29: 273-281.
7. Galichet A, Weibel M, Heizmann CW. Calcium-regulated intramembrane proteolysis of the RAGE receptor. Biochem Biophys Res Commun 370: 1-5, 2008.
8. Gonzalez A, Ravassa S, Lopez B, Beaumonta J, Diez J. Renin-angiotensin-aldosterone system and cardiomyocyte apoptosis in hypertensive heart disease. In: The Local Cardiac Renin-Angiotensin Aldosterone System, edited by Frohlich E and Re R. New York: Springer, 2009, p. 143-150.
9. Grantcharova E, Furkert J, Reusch HP, Krell HW, Papsdorf G, Beyermann M, Schulein R, Rosenthal W, Oksche A. The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process. J Biol Chem 277: 43933-43941, 2002.
10. Grantcharova E, Reusch HP, Grossmann S, Eichhorst J, Krell HW, Beyermann M, Rosenthal W, Oksche A. N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 26: 1288-1296, 2006.
11. Grossmann S, Higashiyama S, Oksche A, Schaefer M, Tannert A. Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling. Mol Membr Biol 26: 279-292, 2009.
12. Hara S, Halicka HD, Bruno S, Gong J, Traganos F, Darzynkiewicz Z. Effect of protease inhibitors on early events of apoptosis. Exp Cell Res 223: 372-384, 1996.
13. Hass MR, Sato C, Kopan R, Zhao G. Presenilin: RIP and beyond. Semin Cell Dev Biol 20: 201-210, 2009.
14. Hu T, Miller CM, Ridder GM, Aardema MJ. Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing. Mutat Res 426: 51-62, 1999.
15. Huynh J, Thomas WG, Aguilar MI, Pattenden LK. Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor. Mol Cell Endocrinol 302: 118-127, 2009.
16. Janicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273: 9357-9360, 1998.
17. Kalderon D, Roberts BL, Richardson WD, Smith AE. A short amino acid sequence able to specify nuclear location. Cell 39: 499-509, 1984.
18. Kojro E, Fahrenholz F. Ligand-induced cleavage of the V2 vasopressin receptor by a plasma membrane metalloproteinase. J Biol Chem 270: 6476-6481, 1995.
19. Kojro E, Postina R, Gilbert S, Bender F, Krause G, Fahrenholz F. Structural requirements for V2 vasopressin receptor proteolytic cleavage. Eur J Biochem 266: 538-548, 1999.
20. Kumar D, Jugdutt BI. Apoptosis and oxidants in the heart. J Lab Clin Med 142: 288-297, 2003.
21. Kumar D, Kirshenbaum LA, Li T, Danelisen I, Singal PK. Apoptosis in adriamycin cardiomyopathy and its modulation by probucol. Antioxid Redox Signal 3: 135-145, 2001.
22. Lal M, Song X, Pluznick JL, Di Giovanni V, Merrick DM, Rosenblum ND, Chauvet V, Gottardi CJ, Pei Y, Caplan MJ. Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet 17: 3105-3117, 2008.
23. Liu JJ, Li DL, Zhou J, Sun L, Zhao M, Kong SS, Wang YH, Yu XJ, Zhou J, Zang WJ. Acetylcholine prevents angiotensin II-induced oxidative stress and apoptosis in H9c2 cells. Apoptosis 16: 94-103, 2011.
24. Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev Cell 10: 57-69, 2006.
25. Lu D, Yang H, Shaw G, Raizada MK. Angiotensin II-induced nuclear targeting of the angiotensin type 1 (AT1) receptor in brain neurons. Endocrinology 139: 365-375, 1998.
26. Mathew D, Ataman B, Chen J, Zhang Y, Cumberledge S, Budnik V. Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310: 1344-1347, 2005.
27. Moliaka YK, Grigorenko A, Madera D, Rogaev EI. Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein. FEBS Lett 557: 185-192, 2004.
28. Morinelli TA, Raymond JR, Baldys A, Yang Q, Lee MH, Luttrell L, Ullian ME. Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation. Am J Physiol Cell Physiol 292: C1398-C1408, 2007.
29. Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H. The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis. Neurosci Lett 444: 127-131, 2008.
30. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw BA. Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335: 1182-1189, 1996.
31. Narula J, Kolodgie FD, Virmani R. Apoptosis and cardiomyopathy. Curr Opin Cardiol 15: 183-188, 2000.
32. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, Di Loreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P. Apoptosis in the failing human heart. N Engl J Med 336: 1131-1141, 1997.
33. Polavarapu R, An J, Zhang C, Yepes M. Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death. Am J Pathol 172: 1355-1362, 2008.
34. Sabbah HN. Apoptotic cell death in heart failure. Cardiovasc Res 45: 704-712, 2000.
35. Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 73: 413-423, 1993.
36. Singal PK, Iliskovic N, Li T, Kumar D. Adriamycin cardiomyopathy: pathophysiology and prevention. FASEB J 11: 931-936, 1997.
37. Terasaki M, Campagnola P, Rolls MM, Stein PA, Ellenberg J, Hinkle B, Slepchenko B. A new model for nuclear envelope breakdown. Mol Biol Cell 12: 503-510, 2001.
38. Tuncdemir M, Ozturk M. The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy. Acta Histochem 2011 Jan 24.
39. Venugopal C, Pappolla MA, Sambamurti K. Insulysin cleaves the APP cytoplasmic fragment at multiple sites. Neurochem Res 32: 2225-2234, 2007.
40. Yu A, McMaster CR, Byers DM, Ridgway ND, Cook HW. Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1. J Biol Chem 278: 9706-9714, 2003.