Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi

Marine Drugs

Volumn 9, Issue 10, 2011, Pages 2036-2045

  Tai, Chi Jen ^a   Su, Jui Hsin ^b,c   Huang, Ming Shyan ^d,e   Wen, Zhi Hong ^a   Dai, Chang Feng ^f   Sheu, Jyh Horng ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^c NATIONAL DONG HWA UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Anti inflammatory activity; Cladiella krempfi; Cytotoxic activity; Eunicellin based diterpenoids; Krempfielins; Soft coral

Indexed keywords

CYCLOOXYGENASE 2; DITERPENOID; KREMPFIELIN A; KREMPFIELIN B; KREMPFIELIN C; KREMPFIELIN D; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CLADIELLA KREMPFI; CONTROLLED STUDY; CORAL; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; SPECTROSCOPY;

ALCYONACEA; CLADIELLA;

EID: 80054915501     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md9102036     Document Type: Article

References (21)

1. Sarma, N.S.; Chavakula, R.; Rao, I.N.; Kadirvelraj, R.; Row, T.N.G.; Saito, I. Crystal and molecular structure of sclerophytin F methyl ether from the soft coral Cladiella krempfi. J. Nat. Prod. 1993, 56, 1977-1980. (Pubitemid 23348573)
2. Lan, W.-J.; Lin, C.-W.; Su, J.-Y.; Zeng, L.-M. Two steroidal glycosides from the soft coral Cladiella krempfi. Chem. J. Chin. Univ. 2003, 24, 2019-2021.
3. Huang, X.-P.; Deng, Z.-W.; Ofwegen, L.V.; Li, J.; Fu, H.-Z.; Zhu, X.-B.; Lin, W.-H. Two new pregnane glycosides from soft coral Cladiella krempfi. J. Asian Nat. Prod. Res. 2006, 8, 287-291. (Pubitemid 44180292)
4. Huang, X.-P.; Deng, Z.-W.; Zhu, X.-B.; Ofwegen, L.V.; Proksch, P.; Lin, W.-H. Krempenes A-D: A series of unprecedented pregnane-type steroids from the marine soft coral Cladiella krempfi. Helv. Chim. Acta 2006, 89, 2020-2026.
5. Wang, G.-H.; Sheu, J.-H.; Chiang, M.Y.; Lee, T.-J. Pachyclavulariaenones A-C, three novel diterpenoids from the soft coral Pachyclavularia violacea. Tetrahedron Lett. 2001, 42, 2333-2336. (Pubitemid 32200438)
6. Wang, G.-H.; Sheu, J.-H.; Duh, C.-Y.; Chiang, M.Y. Pachyclavulariaenones D-G, new diterpenoids from the soft coral Pachyclavularia violacea. J. Nat. Prod. 2002, 65, 1475-1478. (Pubitemid 35239636)
7. Ahmed, A.F.; Wu, M.-H.; Wang, G.-H.; Wu, Y.-C.; Sheu, J.-H. Eunicellin-based diterpenoids, australins A-D, isolated from the soft coral Cladiella australis. J. Nat. Prod. 2005, 68, 1051-1055. (Pubitemid 41151761)
8. Chen, B.-W.; Chang, S.-M.; Huang, C.-Y.; Chao, C.-H.; Su, J.-H.; Wen, Z.-H.; Hsu, C.-H.; Dai, C.-F.; Wu, Y.-C.; Sheu, J.-H. Hirsutalins A-H, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta. J. Nat. Prod. 2010, 73, 1785-1791.
9. Su, J.-H.; Huang, H.-C.; Chao, C.-H.; Yan, L.-Y.; Wu, Y.-C.; Wu, C.-C.; Sheu, J.-H. Vigulariol, a new metabolite from the sea pen Vigularia juncea. Bull. Chem. Soc. Jpn. 2005, 78, 877-879. (Pubitemid 40780318)
10. Wu, S.-L.; Su, J.-H.; Wen, Z.-H.; Hsu, C.-H.; Chen, B.-W.; Dai, C.-F.; Kuo, Y.-H.; Sheu, J.-H. Simplexins A-I, eunicellin-based diterpenoids from the soft coral Klyxum simplex. J. Nat. Prod. 2009, 72, 994-1000.
11. Wu, S.-L.; Su, J.-H.; Lu, Y.; Chen, B.-W.; Huang, C.-Y.; Wen, Z.-H.; Kuo, Y.-H.; Sheu, J.-H. Simplexins J-O, eunicellin-based diterpenoids from a Dongsha Atoll soft coral Klyxum simplex. Bull. Chem. Soc. Jpn. 2011, 84, 626-632.
12. Chen, B.-W.; Wu, Y.-C.; Chiang, M.Y.; Su, J.-H.; Wang, W.-H.; Fan, T.-Y.; Sheu, J.-H. Eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex. Tetrahedron 2009, 65, 7016-7022.
13. Chen, B.-W.; Chao, C.-H.; Su, J.-H.; Wen, Z.-H.; Sung, P.-J.; Sheu, J.-H. Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex. Org. Biomol. Chem. 2010, 8, 2363-2366.
14. Chen, B.-W.; Chao, C.-H.; Su, J.-H.; Tsai, C.-W.; Wang, W.-H.; Wen, Z.-H.; Huang, C.-Y.; Sung, P.-J.; Wu, Y.-C.; Sheu, J.-H. Klysimplexins I-T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex. Org. Biomol. Chem. 2011, 9, 834-844.
15. Chen, Y.-H.; Tai, C.-Y.; Su, Y.-D.; Chang, Y.-C.; Lu, M.-C.; Weng, C.-F.; Su, J.-H.; Hwang, T.-L.; Wu, Y.-C.; Sung, P.-J. Discovery of new eunicellins from an Indonesian octocoral Cladiella sp. Mar. Drugs 2011, 9, 934-943.
16. Miyamoto, T.; Yamada, K.; Ikeda, N.; Komori, T.; Higuchi, R. Bioactive terpenoids from octocorallia, I. Bioactive diterpenoids: Litophynols A and B from the mucus of the soft coral Litophyton sp. J. Nat. Prod. 1994, 57, 1212-1219. (Pubitemid 24333030)
17. Rao, C.B.; Rao, D.S.; Satyanarayana, C.; Rao, D.V.; Kassühlke, K.E.; Faulkner, D.J. New cladiellane diterpenes from the soft coral Cladiella australis of the Andaman and Nicobar Islands. J. Nat. Prod. 1994, 57, 574-580. (Pubitemid 24196749)
18. Alley, M.C.; Scudiero, D.A.; Monks, A.; Hursey, M.L.; Czerwinski, M.J.; Fine, D.L.; Abbott, B.J.; Mayo, J.G.; Shoemaker, R.H.; Boyd, M.R. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 1988, 48, 589-601. (Pubitemid 18056527)
19. Scudiero, D.A.; Shoemaker, R.H.; Paull, K.D.; Monks, A.; Tierney, S.; Nofziger, T.H.; Currens, M.J.; Seniff, D.; Boyd, M.R. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 1988, 48, 4827-4833.
20. Jean, Y.-H.; Chen, W.-F.; Sung, C.-S.; Duh, C.-Y.; Huang, S.-Y.; Lin, C.-S.; Tai, M.-H.; Tzeng, S.-F.; Wen, Z.-H. Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. Br. J. Pharmacol. 2009, 158, 713-725.
21. Jean, Y.-H.; Chen, W.-F.; Duh, C.-Y.; Huang, S.-Y.; Hsu, C.-H.; Lin, C.-S.; Sung, C.-S.; Chen, I.-M.; Wen, Z.-H. Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni. Eur. J. Pharmacol. 2008, 578, 323-331. (Pubitemid 350309573)