Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5473-5479

  Aslam, Muhammad Adil S ^a   Mahmood, Shams Ul ^b   Shahid, Mohammad ^c   Saeed, Aamer ^b   Iqbal, Jamshed ^a  

^a Tobe Camp University Road Abbottabad   (Pakistan)

^b QUAID I AZAM UNIVERSITY   (Pakistan)

^c FRAUNHOFER INSTITUTE FOR ALGORITHMS AND SCIENTIFIC COMPUTING SCAI   (Germany)

Author keywords

Competitive inhibition; Docking studies; Electrostatic potential; Schiff base; Thiourea derivatives; Urease inhibition

Indexed keywords

1 (2 CHLOROBENZYLIDENE)THIOSEMICARBAZIDE; 1 (3 BROMOBENZYLIDENE)THIOSEMICARBAZIDE; 1 (3 CHLOROBENZYLIDENE)THIOSEMICARBAZIDE; 1 (3 METHOXYBENZYLIDENE)THIOSEMICARBAZIDE; 1 (3 NITROBENZYLIDENE)THIOSEMICARBAZIDE; 1 (3 PHENYLALLYLIDENE)THIOSEMICARBAZIDE; 1 (3,4,5 TRIMETHOXYBENZYLIDENE)THIOSEMICARBAZIDE; 1 (4 BROMOBENZYLIDENE)THIOSEMICARBAZIDE; 1 (4 CHLOROBENZYLIDENE)THIOSEMICARBAZIDE; 1 (4 METHOXYBENZYLIDENE)THIOSEMICARBAZIDE; 1 (4 NITROBENZYLIDENE)THIOSEMICARBAZIDE; 1 [4 (N,N DIMETHYLAMINO)BENZYLIDENE]THIOSEMICARBAZIDE; 2 (2,3 DIHYDROXYBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (4 HYDROXY 3,5 DIMETHOXYBENZYLIDENE)HYDRAZINE CARBOTHIOAMIDE; 2 (4 HYDROXYBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (BUT 2 ENYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 [2 (BENZYLOXY)BENZYLIDENE]HYDRAZINECARBOTHIOAMIDE; 2 [3 (BENZYLOXY) 4 METHOXYBENZYLIDENE]HYDRAZINE CARBOTHIOAMIDE; JACK BEAN UREASE; SCHIFF BASE; THIOUREA; UNCLASSIFIED DRUG; UREASE; UREASE INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; HELICOBACTER PYLORI; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MECHANICS; NONHUMAN; PHARMACOPHORE;

CANAVALIA; CHEMISTRY TECHNIQUES, SYNTHETIC; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SCHIFF BASES; UREASE;

EID: 80054911088     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.009     Document Type: Article

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