Synthesis, crystal structures and urease inhibitory activity of copper(II) complexes with Schiff bases

Inorganic Chemistry Communications

Volumn 13, Issue 8, 2010, Pages 996-998

  You, Zhong Lu ^a   Zhang, Lin ^a   Shi, Da Hua ^b   Wang, Xiao Ling ^a   Li, Xiao Fang ^a   Ma, Yu Ping ^a  

^a LIAONING NORMAL UNIVERSITY   (China)

^b HUAIHAI INSTITUTE OF TECHNOLOGY   (China)

Author keywords

Copper complex; Crystal structure; Synthesis; Urease inhibition

Indexed keywords

EID: 77953870414     PISSN: 13877003     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.inoche.2010.05.016     Document Type: Article

References (31)

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24. The two Schiff bases were prepared by reaction of equimolar quantities of the corresponding aldehydes with N-propylethane-1, 2-diamine in methanol solutions and subsequent evaporation of the solvent. Anal. Calc. for C12H17BrN2O (HL1): C 50.5, H 6.0, N 9.8%. Found: C 50.2, H 6.1, N 10.0%. Anal. Calc. for C14H22N2O2 (HL2): C 67.2, H 8.9, N 11.2%. Found: C 66.8, H 8.9, N 11.5%. Selected IR data (KBr, cm-1): HL1, ν 1645 (s, C = N); HL2, ν 1639 (s, C = N).
25. The copper(II) complexes were synthesized according to the same method: A methanol solution (2 ml) of Cu(CH3COO)2·H2O (0.1 mmol, 20.0 mg) was added with stirring to a methanol solution (10 ml) of NH4NCS (0.1 mmol, 7.6 mg) and the corresponding Schiff base (0.1 mmol). The mixture was stirred at room temperature for 30 min to give a blue solution. X-ray quality blue block-shaped single crystals were formed by slow evaporation of the solution in air for a few days. Yield: 82% for 1, and 73% for 2. Anal. Calc. for C13H16BrCuN3OS (1): C 38.5, H 4.0, N 10.4%. Found: C 38.9, H 4.2, N 10.1%. Anal. Calc. for C15H21CuN3O2S (2): C 48.6, H 5.7, N 11.3%. Found: C 48.3, H 5.8, N 11.0%. Selected IR data (KBr, cm-1): 1, ν 3176 (m, N-H), ν 2062 (vs, NCS), ν 1637 (vs, C = N). 2, ν 3183 (m, N-H), ν 2065 (vs, NCS), ν 1631 (vs, C = N).
26. The X-ray single crystal diffraction measurement was carried out at 298(2) K on a Bruker Smart 1000 CCD area diffractometer. The unit cell parameters and data collection was performed with MoKα (λ = 0.71073 Å) radiation. The crystal data and structural parameters for 1: C13H16BrCuN3OS, M = 405.8, monoclinic, space group P21/n, a = 6.007(2), b = 21.133(7), c = 12.336(4) Ǻ, β = 94.634(6)o, V = 1560.9(9) Ǻ3, Z = 4, ρcalcd = 1.727 g cm-3, T = 298(2) K, μ(Mo Kα) = 4.091 mm-1, R1 = 0.0341, wR2 = 0.0753 (all data). The crystal data and structural parameters for 2: C15H21CuN3O2S, M = 370.9, monoclinic, space group P21/c, a = 12.403(2), b = 13.446(2), c = 10.361(2) Ǻ, β = 90.420(7)o, V = 1728.4(5) Ǻ3, Z = 4, ρcalcd = 1.426 g cm-3, T = 298(2) K, μ(Mo Kα) = 1.393 mm-1, R1 = 0.0355, wR2 = 0.0931 (all data).
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