Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: Possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway

Journal of Ethnopharmacology

Volumn 137, Issue 3, 2011, Pages 1462-1468

  Hu, Yue Yu ^a   Huang, Man ^a   Dong, Xiao Qiao ^b   Xu, Qiu Ping ^a   Yu, Wen Hua ^b   Zhang, Zu Yong ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Ginkgolide B; Inflammatory cytokine; Intracerebral hemorrhage; Neuronal cell apoptosis; Nuclear factor kappa B; Toll like receptor 4

Indexed keywords

GINKGOLIDE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN HEMORRHAGE; BRAIN TISSUE; CELL COUNT; CONTROLLED STUDY; DECAPITATION; DRUG EFFECT; GENE EXPRESSION; MALE; NERVE CELL; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BRAIN; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GINKGO BILOBA; GINKGOLIDES; INFLAMMATION MEDIATORS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1BETA; INTERLEUKIN-6; LACTONES; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

GINKGO BILOBA; GINKGOACEAE; RATTUS; RATTUS NORVEGICUS;

EID: 80054891680     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.08.034     Document Type: Article

References (61)

1. A. Aderem, and R.J. Ulevitch Toll-like receptors in the induction of the innate immune response Nature 6797 2000 782 787
2. S. Akiba, T. Kawauchi, T. Oka, T. Hashizume, and T. Sato Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation Biochemistry and Molecular Biology International 46 1998 1243 1248
3. S. Akira, K. Takeda, and T. Kaisho Toll-like receptors: critical proteins linking innate and acquired immunity Nature Immunology 2 2001 675 680
4. K.V. Anderson Toll signaling pathways in the innate immune response Current Opinion in Immunology 12 2000 13 19
5. S. Andrieu, P.J. Ousset, N. Coley, M. Ouzid, H. Mathiex-Fortunet, B. Vellas GuidAge study Group GuidAge study: a 5-year double blind, randomised trial of EGb 761 for the prevention of Alzheimer's disease in elderly subjects with memory complaints. i. Rationale, design and baseline data Current Alzheimer Research 5 2008 406 415
6. J. Aronowski, and C.E. Hall New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies Neurological research 27 2005 268 279
7. M.J. Attella, S.W. Hoffman, M.J. Stasio, and D.G. Stein Ginkgo biloba extract facilitates recovery from penetrating brain injury in adult male rats Experimental Neurology 105 1989 62 71
8. P. Ballabh, A. Braun, and M. Nedergaard The blood-brain barrier: an overview: structure, regulation, and clinical implications Neurobiology of Disease 16 2004 1 13
9. D.J. Begley, and M.W. Brightman Structural and functional aspects of the blood-brain barrier Progress in Drug Research 61 2003 39 78
10. W.M. Clark, L.G. Rinker, N.S. Lessov, S.L. Lowery, and M.J. Cipolla Efficacy of antioxidant therapies in transient focal ischemia in mice Stroke 32 2001 1000 1004
11. S. Desquand, C. Touvay, J. Randon, V. Lagente, B. Vilain, I. Maridonneau-Parini, A. Etienne, J. Lefort, P. Braquet, and B.B. Vargaftig Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig European Journal of Pharmacology 127 1986 83 95
12. M.N. Diringer Intracerebral hemorrhage: pathophysiology and management Critical Care Medicine 21 1993 1591 1603
13. U. Dirnagl, C. Iadecola, and M.A. Moskowitz Pathobiology of ischaemic stroke: an integrated view Trends in Neurosciences 22 1999 391 397
14. K. Drieu Preparation and definition of Ginkgo biloba extract Presse Medicale 15 1986 1455 1457
15. W. Fang, Y. Deng, Y. Li, E. Shang, F. Fang, P. Lv, L. Bai, Y. Qi, F. Yan, and L. Mao Blood-brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia-reperfusion injury European Journal of Pharmaceutical Sciences 39 2010 8 14
16. D.A. Godoy-Torres, and G. PiHeiro Inflammatory response in spontaneous intracerebral hemorrhage Revista de Neurologia 40 2005 492 497
17. D. He, L. Zhao, L. Li, H. Liu, L. Zhang, and D.T. Yew Changes of blood flow perfusion by MR and NF-κβ expression in the region of perihematoma after experimental intracerebral hemorrhage: a correlation study International Journal of Neuroscience 119 2009 806 814
18. S.L. Hickenbottom, J.C. Grotta, R. Strong, L.A. Denner, and J. Aronowski Nuclear factor-κB and cell death after experimental intracerebral hemorrhage in rats Stroke 30 1999 2472 2478
19. K. Hoshino, T. Kaisho, T. Iwabe, O. Takeuchi, and S. Akira Differential involvement of IFN-β in Toll-like receptor-stimulated dendritic cell activation International Immunology 14 2002 1225 1231
20. J.Y. Huang, J.N. Sun, and S.C. Mei Protective effects of ginkgolide B on cerebral ischemia reperfusion injury in rats Chinese Pharmacological Bulletin 24 2008 269 272
21. ®) treatment of dementia with neuropsychiatric features. Retrospective data analyses of a randomized controlled trial Journal of the Neurological Sciences 299 2010 184 187
22. J. Kleijnen, and P. Knipschild Ginkgo biloba Lancet 340 1992 1136 1139
23. L.Y. Li, X.L. Zhao, X.F. Fei, Z.L. Gu, Z.H. Qin, and Z.Q. Liang Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra Acta Pharmacologica Sinica 29 2008 539 547
24. R. Li, B. Chen, W. Wu, L. Bao, J. Li, and R. Qi Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factor-kappaB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein Journal of Pharmacological Sciences 110 2009 362 369
25. S.Q. Li, Y. Zhang, and L.J. Yang Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrews Chinese Medical Journal 120 2007 1529 1533
26. N.S. Ling, Z.F. Pi, R.H. Du, X.D. Zhang, and T. Geng Study on the antioxidative effect of ginkgolide B to the ischemia-reperfused rabbit Journal of Harbin University of Commerce Nature Sciences Edition 18 2002 83 85
27. Y.G. Liu, F.J. Li, J. Wang, and X.D. Wang Effects of Ginkgolide B on inflammation induced by cerebral ischemia-reperfusion in rats Zhong Yao Cai 33 2010 578 580
28. K.M. Maclennan, C.L. Darlington, and P.F. Smith The CNS effects of Ginkgo biloba extracts and ginkgolide B Progress in Neurobiology 67 2002 235 257
29. L. Marcocci, L. Packer, M.T. Droy-Lefaix, A. Sekaki, and M. Gards-Albert Antioxidant action of Ginkgo biloba extract EGb 761 Methods in Enzymology 234 1994 462 475
30. T. Nakamura, Y. Kuroda, N. Hosomi, N. Okabe, N. Kawai, T. Tamiya, G. Xi, R.F. Keep, and T. Itano Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat Acta Neurochirurgica 106 2010 307 310
31. Z.G. Nie, S.Y. Peng, and W.J. Wang Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes Yao Xue Xue Bao 39 2004 415 418
32. F.S. Paul, M. Karyn, and L.D. Cynthia The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF) Journal of Ethnopharmacology 50 1996 131 139
33. S.Y. Peng, W.H. Liao, Z.G. Nie, Y. Liu, L. Wang, F. Wang, and W.J. Wang Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes Yao Xue Xue Bao 45 2010 1103 1108
34. B. Pierre, and H. David Ethnopharmacology and the development of natural PAF antagonists as therapeutic agents Journal of Ethnopharmacology 32 1991 135 139
35. J. Pincemail, M. Dupuis, C. Nasr, P. Hans, M. Haag-Berrurier, R. Anton, and C. Deby Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract Experientia 45 1989 708 712
36. B. Qin, G.B. Zhang, D.Y. Chen, M. Xu, and A.H. Li Protective effects of ginkgolide B on neuron injury induced by cerebral ischemia/reperfusion Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 12 2005 17 20
37. A.I. Qureshi, A.D. Mendelow, and D.F. Hanley Intracerebral haemorrhage Lancet 373 2009 1632 1644
38. A.I. Qureshi, S. Tuhrim, J.P. Broderick, H.H. Batjer, H. Hondo, and D.F. Hanley Spontaneous intracerebral hemorrhage New England Journal of Medicine 344 2001 1450 1460
39. M. Ribo, and J.C. Grotta Latest advances in intracerebral hemorrhage Current Neurology and Neuroscience Reports 6 2006 17 22
40. C. Shi, F. Wu, D.T. Yew, J. Xu, and Y. Zhu Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells Apoptosis 15 2010 715 727
41. G.R. Sutherland, and R.N. Auer Primary intracerebral hemorrhage Journal of Clinical Neuroscience 13 2006 511 517
42. W. Teng, L. Wang, W. Xue, and C. Guan Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats Mediators of Inflammation 2009 473276
43. V. Toshchakov, B.W. Jones, and P.Y. Perera TLR4, but not TLR2, mediates IFN-β-induced STATI α/β-dependent gene expression in macrophages Nature Immunology 3 2002 298 392
44. M. van Dongen, E. van Rossum, A. Kessels, H. Sielhorst, and P. Knipschild Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial Journal of Clinical Epidemiology 56 2003 367 376
45. M.C. van Dongen, E. van Rossum, A.G. Kessels, H.J. Sielhorst, and P.G. Knipschild The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial Journal of the American Geriatrics Society 48 2000 1183 1194
46. B.B. Vargaftig, and J. Benveniste Platelet-activating factor today Trends in Pharmacological Sciences 4 1983 341 343
47. B.B. Vargaftig, J. Lefort, M. Chignard, and J. Benveniste Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives European Journal of Pharmacology 65 1980 185 192
48. B. Vellas, S. Andrieu, P.J. Ousset, M. Ouzid, H. Mathiex-Fortunet GuidAge Study Group The GuidAge study: methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint Neurology 67 2006 S6 S11
49. K.R. Wagner Modeling intracerebral hemorrhage: glutamate, nuclear factor-κB signaling and cytokines Stroke 38 2007 753 758
50. S. Wan, R. Zhan, S. Zheng, Y. Hua, and G. Xi Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: the role of iron Neuroscience Research 63 2008 100 105
51. J.H. Wang, and G.Y. Sun Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC) Neurochemical Research 25 2000 613 619
52. J. Wang Preclinical and clinical research on inflammation after intracerebral hemorrhage Progress in Neurobiology 92 2010 463 477
53. X. Wu, Z. Qian, Y. Ke, F. Du, and L. Zhu Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis Journal of Cellular and Molecular Medicine 13 2009 4474 4483
54. S.H. Xia, and D.C. Fang Pharmacological action and mechanisms of ginkgolide B Chinese Medical Journal 120 2007 922 928
55. Q. Xiao, C. Wang, J. Li, Q. Hou, J. Li, J. Ma, W. Wang, and Z. Wang Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor European Journal of Pharmacology 647 2010 48 54
56. Z.Z. Yang, J. Li, S.X. Li, W. Feng, and H. Wang Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats Journal of Ethnopharmacology 136 2011 117 122
57. S. Zhang, B. Chen, W. Wu, L. Bao, and R. Qi Ginkgolide B reduces inflammatory protein expression in oxidized low-density lipoprotein-stimulated human vascular endothelial cells Journal of Cardiovascular Pharmacology 57 2011 721 727
58. S.F. Zhang, J.Y. Huang, and J. Wang Effect of ginkgolide B injection on rat cerebral ischemia reperfusion lesion Journal of Bejing University of Traditional Chinese Medicine 29 2006 836 839
59. X. Zhang, H. Li, S. Hu, L. Zhang, C. Liu, C. Zhu, R. Liu, and C. Li Brain edema after intracerebral hemorrhage in rats: the role of inflammation Neurology India 54 2006 402 407
60. X. Zhao, Y. Zhang, R. Strong, J. Zhang, J.C. Grotta, and J. Aronowski Distinct patterns of intracerebral hemorrhage-induced alterations in NF-κB subunit, iNOS, and COX-2 expression Journal of Neurochemistry 101 2007 652 663
61. L.J Zhou, and X.Z. Zhu Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide Journal of Pharmacology and Experimental Therapeutics 293 2000 982 988