Baseline neuropsychiatric symptoms are effect modifiers in Ginkgo biloba extract (EGb 761®) treatment of dementia with neuropsychiatric features. Retrospective data analyses of a randomized controlled trial

Journal of the Neurological Sciences

Volumn 299, Issue 1-2, 2010, Pages 184-187

  Ihl, R ^a   Tribanek, M ^b   Bachinskaya, N ^c  

^a Krankenhaus Maria Hilf GmbH   (Germany)

^b DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

^c INSTITUTE OF GERONTOLOGY   (Ukraine)

Author keywords

Alzheimer's disease; Dementia; EGb 761 ; Ginkgo biloba; Neuropsychiatric symptoms; Randomized controlled trial; Vascular dementia

Indexed keywords

GINKGO BILOBA EXTRACT;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; GINKGO BILOBA; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHIATRY; OUTCOME ASSESSMENT; OUTPATIENT; PATIENT SELECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; SCORING SYSTEM; TREATMENT DURATION;

DEMENTIA; FEMALE; GINKGO BILOBA; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PHYTOTHERAPY; PLANT EXTRACTS; REGRESSION ANALYSIS; TREATMENT OUTCOME;

EID: 78649498958     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2010.08.033     Document Type: Article

References (32)

1. B. Hofferberth The efficacy of EGb 761 in patients with senile dementia of the Alzheimer type, a double-blind, placebo-controlled study on different levels of investigation Hum Psychopharmacol 9 1994 215 222
2. K. Maurer, R. Ihl, T. Dierks, and L. Frölich Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type J Psychiatr Res 31 1997 645 655
3. S. Kanowski, W.M. Herrmann, K. Stephan, W. Wierich, and R. Hörr Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia Pharmacopsychiatry 29 1996 47 56
4. S. Kanowski, and R. Hoerr Ginkgo biloba extract EGb 761® in dementia: intent-to-treat analyses of a 24-week, multi-centre, double-blind, placebo-controlled, randomised trial Pharmacopsychiatry 36 2003 297 303
5. P.L. Le Bars, M.M. Katz, N. Berman, T.M. Itil, A.M. Freedman, and A.F. Schatzberg A placebo-controlled, double-blind randomized trial of an extract of Ginkgo biloba for dementia JAMA 278 1997 1327 1332
6. O. Napryeyenko, I. Borzenko for the GINDEM-NP Study Group Ginkgo biloba special extract in dementia with neuropsychiatric features Arzneimittelforschung 57 2007 4 11
7. Ihl R, Bachinskaya N, Korczyn AD, Tribanek M, Hoerr R, Napryeyenko O, on behalf of the GOTADAY Study Group. Efficacy and Safety of a Once-Daily Formulation of Ginkgo biloba Extract EGb 761® in Dementia with Neuropsychiatric Features. A Randomized Controlled Trial. In preparation.
8. L.S. Schneider, S.T. DeKosky, M.R. Farlow, P.N. Tariot, R. Hoerr, and M. Kieser A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type Curr Alzheimer Res 2 2005 541 551
9. R. Hoerr Behavioural and psychological symptoms of dementia (BPSD): effects of EGb 761® Pharmacopsychiatry 36 suppl 1 2003 S56 S61
10. M. Steinberg, H. Shao, P. Zandi, C.G. Lyketsos, K.A. Welsh-Bohmer, and M.C. Norton Point and 5-year prevalence of neuropsychiatric symptoms in dementia: the Cache County Study Int J Geriatr Psychiatry 23 2008 170 177 (Pubitemid 351308497)
11. C.G. Lyketsos, M. Steinberg, J.T. Tschanz, M.C. Norton, D.C. Steffens, and J.C.S. Breitner Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging Am J Psychiatry 157 2000 708 714
12. Y.E. Geda, R.O. Roberts, D.S. Knopman, R.C. Petersen, T.J.H. Christianson, and V.S. Pankratz Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging Arch Gen Psychiatry 65 2008 1193 1198
13. E.R. Edwards, A.P. Spira, D.E. Barnes, and K. Yaffe Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia Int J Geriatr Psychiatry 24 2009 716 722
14. S. Banerjee, S.C. Smith, D.L. Lamping, R.H. Harwood, B. Foley, and P. Smith Quality of life in dementia: more than just cognition. An analysis of associations with quality of life in dementia J Neurol Neurosurg Psychiatry 77 2006 146 148
15. D.W. Gilley, J.L. Bienias, R.S. Wilson, D.A. Bennett, T.L. Beck, and D.A. Evans Influence of behavioral symptoms on rates of institutionalization for persons with Alzheimer's disease Psychol Med 34 2004 1129 1135
16. S.M. Tun, D.L. Murman, H.L. Long, C.C. Colenda, and A. von Eye Predictive validity of neuropsychiatric subgroups on nursing home placement and survival in patients with Alzheimer disease Am J Geriatr Psychiatry 15 2007 314 327
17. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 1984 939 944
18. G.C. Román, T.K. Tatemichi, T. Erkinjuntti, J.L. Cummings, J.C. Masdeu, and J.H. Garcia Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop Neurology 43 1993 250 260
19. R. Ihl, B. Grass-Kapanke, P. Lahrem, J. Brinkmeyer, S. Fischer, and N. Gaab Entwicklung und Validierung eines Tests zur Früherkennung der Demenz mit Depressionsabgrenzung (TFDD) Development and validation of a test for early diagnosis of dementia with differentiation from depression (TFDD) Fortschr Neurol Psychiatr 68 2000 413 422
20. J. Brinkmeyer, B. Grass-Kapanke, and R. Ihl EEG and the Test for the Early Detection of Dementia with Discrimination from Depression (TE4D): a validation study Int J Geriatr Psychiatry 19 2004 749 753
21. R. Mahoney, K. Johnston, C. Katona, K. Maxmin, and G. Livingston The TE4D-Cog: a new test for detecting early dementia in English-speaking populations Int J Geriatr Psychiatry 20 2005 1172 1179
22. Y.S. Kim, D.W. Nibbelink, and J.E. Overall Factor structure and scoring of the SKT test battery J Clin Psychol 49 1993 61 71
23. J.L. Cummings The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients Neurology 48 suppl 6 1997 S10 S16
24. M. Hamilton A rating scale for depression J Neurol Neurosurg Psychiatry 23 1960 56 62
25. L.S. Schneider, J.T. Olin, R.S. Doody, C.M. Clark, J.C. Morris, and B. Reisberg Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change Alzheimer Dis Assoc Disord 11 suppl 2 1997 S22 S32
26. B. Reisberg, S. Finkel, J. Overall, N. Schmidt-Gollas, S. Kanowski, and H. Lehfeld The Alzheimer's Disease Activities of Daily Living International Scale (ADL-IS) Int Psychogeriatr 13 2001 163 181
27. S.C. Smith, D.L. Lamping, S. Banerjee, R. Harwood, B. Foley, and P. Smith Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology Health Technol Assess (Southamptom, England) 9 2005 No. 10.
28. A. Burns, R. Jacoby, and R. Levy Psychiatric phenomena in Alzheimer's disease. II: Disorders of perception Br J Psychiatry 157 1990 76 81 (Pubitemid 20208664)
29. J. Rosen, and G.S. Zubenko Emergence of psychosis and depression in the longitudinal evaluation of Alzheimer's disease Biol Psychiatry 29 1991 224 232
30. J.A. Mortimer, B.E. Ebbitt, S.P. Jun, and M.D. Finch Predictors of cognitive and functional progression in patients with probable Alzheimer's disease Neurology 42 1992 1689 1696
31. H.C. Chui, S.A. Lyness, E. Sobel, and L.S. Schneider Extrapyramidal signs and psychiatric symptoms predict faster cognitive decline in Alzheimer's disease Arch Neurol 51 1994 676 681
32. I.S. Shin, M. Carter, D. Masterman, L. Fairbanks, and J.L. Cummings Neuropsychiatric symptoms and quality of life in Alzheimer disease Am J Geriatr Psychiatry 13 2005 469 474