Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5675-5679

  Kimura, Tsutomu ^a,b   Hosokawa Muto, Junji ^a,c   Asami, Kenji ^a   Murai, Toshiaki ^a   Kuwata, Kazuo ^a  

^a GIFU UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c NATIONAL RESEARCH INSTITUTE OF POLICE SCIENCE   (Japan)

Author keywords

2,3,4,9 Tetrahydro 1H carbazole; Anti prion compound; Prion diseases; Ring opening reaction; Structure activity relationships; Transmissible spongiform encephalopathies

Indexed keywords

1 (1 PIPERIDINYL) 3 (1,2,3,4 TETRAHYDRO 9H CARBAZOL 9 YL) 2 PROPANOL; 2,3,4,9 TETRAHYDRO 9 [2 HYDROXY 3 (1 PIPERIDINYL)PROPYL] 6 METHYL 1H CARBAZOL 1 ONE; AMINE; CARBAZOLE DERIVATIVE; ETHYLENE OXIDE DERIVATIVE; HETEROCYCLIC COMPOUND; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRION DISEASE; RING OPENING; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBAZOLES; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; NEURONS; PIPERIDINES; PRION DISEASES;

EID: 80054891678     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.039     Document Type: Article

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