Synthesis of GN8 derivatives and evaluation of their antiprion activity in TSE-infected cells

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1502-1507

  Kimura, Tsutomu ^a   Hosokawa Muto, Junji ^a   Kamatari, Yuji O ^a   Kuwata, Kazuo ^a,b  

^a GIFU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Antiprion compound; Conformational analysis; Prion diseases; Transmissible spongiform encephalopathies

Indexed keywords

AMINO ACID; BENZYL DERIVATIVE; CENTRAL NERVOUS SYSTEM AGENTS; ETHYLENEDIAMINE DERIVATIVE; N,N' (METHYLENEDI 4,1 PHENYLENE)BIS[2 (1 PYRROLIDINYL)ACETAMIDE]; NITROGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPRION ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; HYDROPHOBICITY; IC 50; MOUSE; NONHUMAN; PRION; PRION DISEASE; STRUCTURE ACTIVITY RELATION;

ACETANILIDES; ANIMALS; ANTIPARASITIC AGENTS; BENZHYDRYL COMPOUNDS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; NEURONS; PRION DISEASES; PRIONS; PROTEIN FOLDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951722168     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.132     Document Type: Article

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