-
1
-
-
9744228694
-
Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: Past, present and future prospects
-
DOI 10.1016/j.yjmcc.2004.09.013, PII S0022282804002846
-
Morkin E , Ladenson P , Goldman S , Adamson C . Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects . J Mol Cell Cardiol 2004 ; 37 : 1137 - 1146 (Pubitemid 39585161)
-
(2004)
Journal of Molecular and Cellular Cardiology
, vol.37
, Issue.6
, pp. 1137-1146
-
-
Morkin, E.1
Ladenson, P.2
Goldman, S.3
Adamson, C.4
-
3
-
-
39449118862
-
Effects of thyroid hormone analogs on lipid metabolism and thermogenesis
-
DOI 10.1089/thy.2007.0288
-
Ribeiro M O . Effects of thyroid hormone analogs on lipid metabolism and thermogenesis . Thyroid 2008 ; 18 : 197 - 203 (Pubitemid 351271536)
-
(2008)
Thyroid
, vol.18
, Issue.2
, pp. 197-203
-
-
Ribeiro, M.O.1
-
4
-
-
34848827936
-
Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
-
DOI 10.1073/pnas.0702759104
-
Erion M D , Cable E E , Ito B R , Jiang H , Fujitaki J M , Finn P D , Zhang B H , Hou J , Boyer S H , van Poelje P D , Linemeyer D L . Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index . Proc Natl Acad Sci USA 2007 ; 104 : 15490 - 15495 (Pubitemid 47502944)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.39
, pp. 15490-15495
-
-
Erion, M.D.1
Cable, E.E.2
Ito, B.R.3
Jiang, H.4
Fujitaki, J.M.5
Finn, P.D.6
Zhang, B.-H.7
Hou, J.8
Boyer, S.H.9
Van Poelje, P.D.10
Linemeyer, D.L.11
-
5
-
-
77952325654
-
Impaired Metabolic Eff ects of a Thyroid Hormone Receptor Beta-Selective Agonist in a Mouse Model of Diet-Induced Obesity
-
Castillo M , Freitas BC G , Rosene M L , Drigo R A , Grozovsky R , Maciel RM B , Patti M E , Ribeiro M O , Bianco A C . Impaired Metabolic Eff ects of a Thyroid Hormone Receptor Beta-Selective Agonist in a Mouse Model of Diet-Induced Obesity . Thyroid 2010 ; 20 : 545 - 554
-
(2010)
Thyroid
, vol.20
, pp. 545-554
-
-
Castillo, M.1
Freitas, B.C.G.2
Rosene, M.L.3
Drigo, R.A.4
Grozovsky, R.5
MacIel, R.M.B.6
Patti, M.E.7
Ribeiro, M.O.8
Bianco, A.C.9
-
6
-
-
35148895083
-
Thyroid disease and the heart
-
DOI 10.1161/CIRCULATIONAHA.106.678326, PII 0000301720071009000013
-
Klein I , Danzi S . Thyroid Disease and the Heart . Circulation 2007 ; 116 : 1725 - 1735 (Pubitemid 47537847)
-
(2007)
Circulation
, vol.116
, Issue.15
, pp. 1725-1735
-
-
Klein, I.1
Danzi, S.2
-
7
-
-
0038022874
-
Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone
-
DOI 10.1016/S0303-7207(03)00122-9
-
Sadow P M , Chassande O , Koo E K , Gauthier K , Samarut J , Xu J , O'Malley B W , Weiss R E . Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone . Mol Cell Endocrinol 2003 ; 203 : 65 - 75 (Pubitemid 36627589)
-
(2003)
Molecular and Cellular Endocrinology
, vol.203
, Issue.1-2
, pp. 65-75
-
-
Sadow, P.M.1
Chassande, O.2
Koo, E.K.3
Gauthier, K.4
Samarut, J.5
Xu, J.6
O'Malley, B.W.7
Weiss, R.E.8
-
8
-
-
77949349469
-
Treatment of Dyslipidemia with the Thyroid Hormone Analog Eprotirome in Statin-Treated Patients
-
Ladenson P W , Kristensen J D , Ridgway E C , Olsson A G , Carlsson B , Klein I , Baxter J D , Angelin B . Treatment of Dyslipidemia with the Thyroid Hormone Analog Eprotirome in Statin-Treated Patients . New Engl J Med 2010 ; 362 : 906 - 916
-
(2010)
New Engl J Med
, vol.362
, pp. 906-916
-
-
Ladenson, P.W.1
Kristensen, J.D.2
Ridgway, E.C.3
Olsson, A.G.4
Carlsson, B.5
Klein, I.6
Baxter, J.D.7
Angelin, B.8
-
9
-
-
0029779886
-
Uptake of thyroid hormones in neonatal rat cardiac myocytes
-
DOI 10.1210/en.137.10.4235
-
Everts M E , Verhoeven F A , Bezstarosti K , Moerings E , Hennemann G , Visser T J , Lamers JM J . Uptake of Thyroid Hormones in Neonatal Rat Cardiac Myocytes . Endocrinology 1996 ; 137 : 4235 - 4242 (Pubitemid 26321871)
-
(1996)
Endocrinology
, vol.137
, Issue.10
, pp. 4235-4242
-
-
Everts, M.E.1
Verhoeven, F.A.2
Bezstarosti, K.3
Moerings, E.P.C.M.4
Hennemann, G.5
Visser, T.J.6
Lamers, J.M.J.7
-
11
-
-
0026589086
-
Time course of the eff ects of thyroid hormone on cardiac gene expression
-
Balkman C , Ojamaa K , Klein I . Time course of the eff ects of thyroid hormone on cardiac gene expression . Endocrinology 1992 ; 130 : 2001 - 2006
-
(1992)
Endocrinology
, vol.130
, pp. 2001-2006
-
-
Balkman, C.1
Ojamaa, K.2
Klein, I.3
-
12
-
-
0032101890
-
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor
-
Chiellini G , Apriletti J W , Yoshihara H A , Baxter J D , Ribeiro R C , Scanlan T S . A high-affi nity subtype-selective agonist ligand for the thyroid hormone receptor . Chem Biol 1998 ; 5 : 299 - 306 (Pubitemid 28309983)
-
(1998)
Chemistry and Biology
, vol.5
, Issue.6
, pp. 299-306
-
-
Chiellini, G.1
Apriletti, J.W.2
Yoshihara, H.A.3
Baxter, J.D.4
Ribeiro, R.C.J.5
Scanlan, T.S.6
-
13
-
-
17744387900
-
The thyroid hormone receptor-β-selective agonist GC-1 differentially affects plasma lipids and cardiac activity
-
DOI 10.1210/en.141.9.3057
-
Trost S U , Swanson E , Gloss B , Wang-Iverson D B , Zhang H , Volodarsky T , Grover G J , Baxter J D , Chiellini G , Scanlan T S , Dillmann W H . The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity . Endocrinology 2000 ; 141 : 3057 - 3064 (Pubitemid 32268991)
-
(2000)
Endocrinology
, vol.141
, Issue.9
, pp. 3057-3064
-
-
Trost, S.U.1
Swanson, E.2
Gloss, B.3
Wang-Iverson, D.B.4
Zhang, H.5
Volodarsky, T.6
Grover, G.J.7
Baxter, J.D.8
Chiellini, G.9
Scanlan, T.S.10
Dillmann, W.H.11
-
14
-
-
1642505721
-
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: Selective actions relative to 3,5,3′-triiodo-L-thyronine
-
DOI 10.1210/en.2003-0973
-
Grover G J , Egan D M , Sleph P G , Beehler B C , Chiellini G , Nguyen N H , Baxter J D , Scanlan T S . Eff ects of the thyroid hormone receptor GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3-triiodo-L-thyronine . Endocrinology 2004 ; 145 : 1656 - 1661 (Pubitemid 38402372)
-
(2004)
Endocrinology
, vol.145
, Issue.4
, pp. 1656-1661
-
-
Grover, G.J.1
Egan, D.M.2
Sleph, P.G.3
Beehler, B.C.4
Chiellini, G.5
Nguyen, N.-H.6
Baxter, J.D.7
Scanlan, T.S.8
-
15
-
-
1942453725
-
Selective activation of thyroid hormone signaling pathways by GC-1: A new approach to controlling cholesterol and body weight
-
DOI 10.1016/j.tem.2004.03.008, PII S1043276004000633
-
Baxter J D , Webb P , Grover G , Scanlan T S . Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight . Trends Endocrinol Metab 2004 ; 15 : 154 - 157 (Pubitemid 38510494)
-
(2004)
Trends in Endocrinology and Metabolism
, vol.15
, Issue.4
, pp. 154-157
-
-
Baxter, J.D.1
Webb, P.2
Grover, G.3
Scanlan, T.S.4
-
16
-
-
22644432001
-
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice
-
DOI 10.1073/pnas.0504379102
-
Johansson L , Rudling M , Scanlan T S , Lundasen T , Webb P , Baxter J , Angelin B , Parini P . Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice . Proc Natl Acad Sci USA 2005 ; 102 : 10297 - 10302 (Pubitemid 41024974)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.29
, pp. 10297-10302
-
-
Johansson, L.1
Rudling, M.2
Scanlan, T.S.3
Lundasen, T.4
Webb, P.5
Baxter, J.6
Angelin, B.7
Parini, P.8
-
17
-
-
0034987037
-
Selective modulation of thyroid hormone receptor action
-
DOI 10.1016/S0960-0760(01)00052-8, PII S0960076001000528
-
Baxter J D , Dillmann W H , West B L , Huber R , Furlow J D , Fletterick R J , Webb P , Apriletti J W , Scanlan T S . Selective modulation of thyroid hormone receptor action . J Steroid Biochem Mol Biol 2001 ; 76 : 31 - 42 (Pubitemid 32510665)
-
(2001)
Journal of Steroid Biochemistry and Molecular Biology
, vol.76
, Issue.1-5
, pp. 31-42
-
-
Baxter, J.D.1
Dillmann, W.H.2
West, B.L.3
Huber, R.4
Furlow J.David5
Fletterick, R.J.6
Webb, P.7
Apriletti, J.W.8
Scanlan, T.S.9
-
18
-
-
0037144443
-
A thyroid hormone antagonist that inhibits thyroid hormone action in vivo
-
Lim W , Nguyen N H , Yang H Y , Scanlan T S , Furlow J D . A thyroid hormone antagonist that inhibits thyroid hormone action in vivo . J Biol Chem 2002 ; 277 : 35664 - 35670
-
(2002)
J Biol Chem
, vol.277
, pp. 35664-35670
-
-
Lim, W.1
Nguyen, N.H.2
Yang, H.Y.3
Scanlan, T.S.4
Furlow, J.D.5
-
19
-
-
0037130243
-
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment
-
DOI 10.1021/jm0201013
-
Nguyen N H , Apriletti J W , Cunha Lima S T , Webb P , Baxter J D , Scanlan T S . Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment . J Med Chem 2002 ; 45 : 3310 - 3320 (Pubitemid 34774281)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.15
, pp. 3310-3320
-
-
Nguyen, N.-H.1
Apriletti, J.W.2
Cunha Lima, S.T.3
Webb, P.4
Baxter, J.D.5
Scanlan, T.S.6
-
20
-
-
34250763730
-
Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats
-
DOI 10.1124/jpet.106.116152
-
Grover G J , Dunn C , Nguyen N H , Boulet J , Dong G , Domogauer J , Barbounis P , Scanlan T S . Pharmacological profi le of the thyroid hormone receptor antagonist NH3 in rats . J Pharmacol Exp Ther 2007 ; 322 : 385 - 390 (Pubitemid 46956356)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.322
, Issue.1
, pp. 385-390
-
-
Grover, G.J.1
Dunn, C.2
Nguyen, N.-H.3
Boulet, J.4
Dong, G.5
Domogauer, J.6
Barbounis, P.7
Scanlan, T.S.8
-
21
-
-
18244364644
-
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist
-
DOI 10.1210/en.143.2.517
-
Baxter J D , Goede P , Apriletti J W , West B L , Feng W , Mellstrom K , Fletterick R J , Wagner R L , Kushner P J , Ribeiro R C , Webb P , Scanlan T S , Nilsson S. Structure-Based Design and Synthesis of a Thyroid Hormone Receptor (TR) Antagonist . Endocrinology 2002 ; 143 : 517 - 524 (Pubitemid 34107205)
-
(2002)
Endocrinology
, vol.143
, Issue.2
, pp. 517-524
-
-
Baxter, J.D.1
Goede, P.2
Apriletti, J.W.3
West, B.L.4
Feng, W.5
Mellstrom, K.6
Fletterick, R.J.7
Wagner, R.L.8
Kushner, P.J.9
Ribeiro, R.C.J.10
Webb, P.11
Scanlan, T.S.12
Nilsson, S.13
-
22
-
-
0033965389
-
Rational discovery of novel nuclear hormone receptor antagonists
-
DOI 10.1073/pnas.97.3.1008
-
Schapira M , Raaka B M , Samuels H H , Abagyan R . Rational discovery of novel nuclear hormone receptor antagonists . Proc Natl Acad Sci USA 2000 ; 97 : 1008 - 1013 (Pubitemid 30080803)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.3
, pp. 1008-1013
-
-
Schapira, M.1
Raaka, B.M.2
Samuels, H.H.3
Abagyan, R.4
-
23
-
-
0347364651
-
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor
-
DOI 10.1073/pnas.2136689100
-
Borngraeber S , Budny M J , Chiellini G , Cunha-Lima S T , Togashi M , Webb P , Baxter J D , Scanlan T S , Fletterick R J . Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor . Proc Natl Acad Sci USA 2003 ; 100 : 15358 - 15363 (Pubitemid 38020994)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.26
, pp. 15358-15363
-
-
Borngraeber, S.1
Budny, M.-J.2
Chiellini, G.3
Cunha-Lima, S.T.4
Togashi, M.5
Webb, P.6
Baxter, J.D.7
Scanlan, T.S.8
Fletterick, R.J.9
|