메뉴 건너뛰기




Volumn 3, Issue 9, 2007, Pages 632-640

Potential therapeutic applications of thyroid hormone analogs

Author keywords

Agonists; Analogs; Antagonists; Human disease; Thyroid hormone

Indexed keywords

3' ISOPROPYL 3,5 DIMETHYLTHYRONINE; 3,5 DIBROMO 3' (2,3 DIHYDRO 3 OXO 6 PYRIDAZINYLMETHYL)THYRONINE; 3,5 DIBROMO 4 (3' ISOPROPYL 4' HYDROXYPHENOXY)BENZOIC ACID; 3,5 DIBROMO 4 (3',5' DIISOPROPYL 4' HYDROXYPHENOXY)BENZOIC ACID; 3,5 DICHLORO 4 [(4 HYDROXY 3 ISOPROPYLPHENOXY)PHENYL]ACETIC ACID; 3,5 DIIODOTHYROPROPIONIC ACID; 3,5 DIMETHYL 4 (4' HYDROXY 3' BENZYL)BENZYLPHENOXYACETIC ACID; 3,5 DIMETHYL 4 (4' HYDROXY 3' ISOPROPYLBENZYL)PHENOXYACETIC ACID; AMIODARONE; CAPTOPRIL; GC 1; GC 14; GC 24; HORMONE ANTAGONIST; HY 4; KB 141; LEVOTHYROXINE; LIOTHYRONINE; NH 3; TETRAIODOTHYROACETIC ACID; THYROID HORMONE DERIVATIVE; THYROMIMETIC AGENT; THYROTROPIN; THYROXINE; TIRATRICOL; UNCLASSIFIED DRUG;

EID: 34548086807     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0590     Document Type: Review
Times cited : (68)

References (59)
  • 1
    • 0016385846 scopus 로고
    • Thyroid thermogenesis
    • Edelman IS (1974) Thyroid thermogenesis. N Engl J Med 290: 1303-1308
    • (1974) N Engl J Med , vol.290 , pp. 1303-1308
    • Edelman, I.S.1
  • 2
    • 0025970029 scopus 로고
    • Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat
    • Oppenheimer JH et al. (1991) Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin Invest 87: 125-132
    • (1991) J Clin Invest , vol.87 , pp. 125-132
    • Oppenheimer, J.H.1
  • 3
    • 0035864975 scopus 로고    scopus 로고
    • Thyroid hormone and the cardiovascular system
    • Klein I and Ojamaa K (2001) Thyroid hormone and the cardiovascular system. N Engl J Med 344: 501-509
    • (2001) N Engl J Med , vol.344 , pp. 501-509
    • Klein, I.1    Ojamaa, K.2
  • 4
    • 0034964207 scopus 로고    scopus 로고
    • Physiological and molecular basis of thyroid hormone action
    • Yen PM (2001) Physiological and molecular basis of thyroid hormone action. Physiol Rev 81: 1097-1142
    • (2001) Physiol Rev , vol.81 , pp. 1097-1142
    • Yen, P.M.1
  • 5
    • 0028094947 scopus 로고
    • Thyroid hormone receptor monomer, homodimer, and heterodimer (with retinoid-X receptor) contact different nucleotide sequences in thyroid hormone response elements
    • Ikeda M et al. (1994) Thyroid hormone receptor monomer, homodimer, and heterodimer (with retinoid-X receptor) contact different nucleotide sequences in thyroid hormone response elements. Endocrinology 135: 1628-1638
    • (1994) Endocrinology , vol.135 , pp. 1628-1638
    • Ikeda, M.1
  • 6
    • 33749003446 scopus 로고    scopus 로고
    • Rapid nongenomic actions of thyroid hormone
    • Hiroi Y et al. (2006) Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci USA 103: 14104-14109
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14104-14109
    • Hiroi, Y.1
  • 7
    • 0034987037 scopus 로고    scopus 로고
    • Selective modulation of thyroid hormone receptor action
    • Baxter JD et al. (2001) Selective modulation of thyroid hormone receptor action. J Steroid Biochem Mol Biol 76: 31-42
    • (2001) J Steroid Biochem Mol Biol , vol.76 , pp. 31-42
    • Baxter, J.D.1
  • 8
    • 0001538947 scopus 로고
    • Chemistry of thyroxine. III. Constitution and synthesis of thyroxine
    • Harrington CR and Barger G (1927) Chemistry of thyroxine. III. Constitution and synthesis of thyroxine. Biochem J 21: 169-183
    • (1927) Biochem J , vol.21 , pp. 169-183
    • Harrington, C.R.1    Barger, G.2
  • 9
    • 0000076344 scopus 로고
    • The identification of 3:5:3′-L-triiodothyronine in human plasma
    • Gross J and Pitt-Rivers R (1952) The identification of 3:5:3′-L-triiodothyronine in human plasma. Lancet 1: 439-441
    • (1952) Lancet , vol.1 , pp. 439-441
    • Gross, J.1    Pitt-Rivers, R.2
  • 10
    • 24644436920 scopus 로고    scopus 로고
    • Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
    • Maia AL et al. (2005) Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest 115: 2524-2533
    • (2005) J Clin Invest , vol.115 , pp. 2524-2533
    • Maia, A.L.1
  • 11
    • 25144509449 scopus 로고    scopus 로고
    • Regulation of type 1 iodothyronine deiodinase in health and disease
    • Koenig R (2005) Regulation of type 1 iodothyronine deiodinase in health and disease. Thyroid 15: 835-840
    • (2005) Thyroid , vol.15 , pp. 835-840
    • Koenig, R.1
  • 12
    • 4243851318 scopus 로고    scopus 로고
    • Thyroid hormone structure-function relationships
    • edn 7, Eds Braverman LE and Utiger RD Philadelphia: Lippincott-Raven
    • Cody V (1996) Thyroid hormone structure-function relationships. In Werner and Ingbar's The Thyroid, edn 7, 185-189 (Eds Braverman LE and Utiger RD) Philadelphia: Lippincott-Raven
    • (1996) Werner and Ingbar's The Thyroid , pp. 185-189
    • Cody, V.1
  • 13
    • 0042734823 scopus 로고    scopus 로고
    • Selective thyroid hormone receptor-β activation: A strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability
    • Grover GJ et al. (2003) Selective thyroid hormone receptor-β activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. Proc Natl Acad Sci USA 100: 10067-10072
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10067-10072
    • Grover, G.J.1
  • 14
    • 0033762445 scopus 로고    scopus 로고
    • Cloning and characterization of two novel thyroid hormone receptor β isoforms
    • Williams GR (2000) Cloning and characterization of two novel thyroid hormone receptor β isoforms. Mol Cell Biol 20: 8329-8342
    • (2000) Mol Cell Biol , vol.20 , pp. 8329-8342
    • Williams, G.R.1
  • 15
    • 0025687882 scopus 로고
    • Nuclear thyroid hormone receptors
    • Lazar MA and Chin WW (1990) Nuclear thyroid hormone receptors. J Clin Invest 86: 1777-1782
    • (1990) J Clin Invest , vol.86 , pp. 1777-1782
    • Lazar, M.A.1    Chin, W.W.2
  • 16
    • 23744445796 scopus 로고    scopus 로고
    • Thyroid hormone action in the heart
    • Kahaly GJ and Dillmann WH (2005) Thyroid hormone action in the heart. Endocr Rev 26: 708-728
    • (2005) Endocr Rev , vol.26 , pp. 708-728
    • Kahaly, G.J.1    Dillmann, W.H.2
  • 17
    • 16544395427 scopus 로고    scopus 로고
    • Thyroid hormone and the cardiovascular system
    • Danzi S and Klein I (2004) Thyroid hormone and the cardiovascular system. Minerva Endocrinologica 29: 139-150
    • (2004) Minerva Endocrinologica , vol.29 , pp. 139-150
    • Danzi, S.1    Klein, I.2
  • 18
    • 35148895083 scopus 로고    scopus 로고
    • Thyroid disease and the heart
    • in press
    • Klein I and Danzi S: Thyroid disease and the heart. Circulation, in press
    • Circulation
    • Klein, I.1    Danzi, S.2
  • 19
    • 0034045480 scopus 로고    scopus 로고
    • Transcriptional repression by nuclear hormone receptors
    • Hu X and Lazar MA (2000) Transcriptional repression by nuclear hormone receptors. Trends Endocrinol Metab 11: 6-10
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 6-10
    • Hu, X.1    Lazar, M.A.2
  • 20
    • 16644373256 scopus 로고    scopus 로고
    • Crystallization and preliminary x-ray diffraction studies of isoform ?1 of the human thyroid hormone receptor ligand-binding domain
    • Nunes FM et al. (2004) Crystallization and preliminary x-ray diffraction studies of isoform ?1 of the human thyroid hormone receptor ligand-binding domain. Acta Crystallogr D Biol Crystallogr 60: 1867-1870
    • (2004) Acta Crystallogr D Biol Crystallogr , vol.60 , pp. 1867-1870
    • Nunes, F.M.1
  • 21
    • 0035805580 scopus 로고    scopus 로고
    • Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor
    • Ribeiro RC et al. (2001) Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor. J Biol Chem 276: 14987-4995
    • (2001) J Biol Chem , vol.276 , pp. 14987-14995
    • Ribeiro, R.C.1
  • 22
    • 0029643769 scopus 로고
    • A structural role for hormone in the thyroid hormone receptor
    • Wagner RL et al. (1995) A structural role for hormone in the thyroid hormone receptor. Nature 378: 690-697
    • (1995) Nature , vol.378 , pp. 690-697
    • Wagner, R.L.1
  • 23
    • 0036018267 scopus 로고    scopus 로고
    • Nongenomic actions of thyroid hormone on the heart
    • Davis PJ and Davis FB (2002) Nongenomic actions of thyroid hormone on the heart. Thyroid 12: 459-466
    • (2002) Thyroid , vol.12 , pp. 459-466
    • Davis, P.J.1    Davis, F.B.2
  • 24
    • 0028808234 scopus 로고
    • Thyroid hormone treatment after coronary-artery bypass surgery
    • Klemperer JD et al. (1995) Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med 333: 1522-1527
    • (1995) N Engl J Med , vol.333 , pp. 1522-1527
    • Klemperer, J.D.1
  • 25
    • 0036043679 scopus 로고    scopus 로고
    • Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure
    • Morkin E et al. (2002) Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure. Cardiology 97: 218-225
    • (2002) Cardiology , vol.97 , pp. 218-225
    • Morkin, E.1
  • 26
    • 33645862289 scopus 로고    scopus 로고
    • Dynamic nongenomic actions of thyroid hormone in the developing rat brain
    • Farwell AP et al. (2006) Dynamic nongenomic actions of thyroid hormone in the developing rat brain. Endocrinology 147: 2567-2574
    • (2006) Endocrinology , vol.147 , pp. 2567-2574
    • Farwell, A.P.1
  • 27
    • 2642588897 scopus 로고    scopus 로고
    • Selective activators of thyroid hormone receptors
    • Webb P (2004) Selective activators of thyroid hormone receptors. Expert Opin Investig Drugs 13: 489-500
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 489-500
    • Webb, P.1
  • 28
    • 0026589577 scopus 로고
    • Reduction of cardiovascular and thyroxine-suppressing activities of L-T3 by liver targeting with cholic acid
    • Stephan ZF et al. (1992) Reduction of cardiovascular and thyroxine-suppressing activities of L-T3 by liver targeting with cholic acid. Biochem Pharmacol 43: 1969-1974
    • (1992) Biochem Pharmacol , vol.43 , pp. 1969-1974
    • Stephan, Z.F.1
  • 29
    • 0024553922 scopus 로고
    • Selective thyromimetics. Cardiac-sparing thyroid hormone analogues containing 3′-arylmethyl substituents
    • Leeson PD et al. (1989) Selective thyromimetics. Cardiac-sparing thyroid hormone analogues containing 3′-arylmethyl substituents. J Med Chem 32: 320-336
    • (1989) J Med Chem , vol.32 , pp. 320-336
    • Leeson, P.D.1
  • 30
    • 0021142366 scopus 로고
    • Thyromimetic effects of 3,5-dimethyl,3′-isopropyl thyronine (DIMIT) and 3,5-diethyl,3′- isopropyl thyronine (DIET) in various tissues of the rat
    • Chopra IJ et al. (1984) Thyromimetic effects of 3,5-dimethyl,3′-isopropyl thyronine (DIMIT) and 3,5-diethyl,3′- isopropyl thyronine (DIET) in various tissues of the rat. Metabolism 33: 622-628
    • (1984) Metabolism , vol.33 , pp. 622-628
    • Chopra, I.J.1
  • 31
    • 0024512826 scopus 로고
    • The thyroid hormone analogue SKF L-94901: Nuclear occupancy and serum binding studies
    • Barlow JW et al. (1989) The thyroid hormone analogue SKF L-94901: nuclear occupancy and serum binding studies. Clin Sci (Lond) 76: 495-501
    • (1989) Clin Sci (Lond) , vol.76 , pp. 495-501
    • Barlow, J.W.1
  • 32
    • 0030710984 scopus 로고    scopus 로고
    • Organ-specific effects of 3,5,3′-triiodothyroacetic acid in rats
    • Liang H et al. (1997) Organ-specific effects of 3,5,3′-triiodothyroacetic acid in rats. Eur J Endocrinol 137: 537-544
    • (1997) Eur J Endocrinol , vol.137 , pp. 537-544
    • Liang, H.1
  • 33
    • 0030743442 scopus 로고    scopus 로고
    • Augmented hepatic and skeletal thyromimetic effects of tiratricol in comparison with levothyroxine
    • Sherman SI et al. (1997) Augmented hepatic and skeletal thyromimetic effects of tiratricol in comparison with levothyroxine. J Clin Endocrinol Metab 82: 2153-2158
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2153-2158
    • Sherman, S.I.1
  • 34
    • 0035118770 scopus 로고    scopus 로고
    • Differences between the effects of thyroxine and tetraiodothyroacetic acid on TSH suppression and cardiac hypertrophy
    • Lameloise N et al. (2001) Differences between the effects of thyroxine and tetraiodothyroacetic acid on TSH suppression and cardiac hypertrophy. Eur J Endocrinol 144: 145-154
    • (2001) Eur J Endocrinol , vol.144 , pp. 145-154
    • Lameloise, N.1
  • 35
    • 17744379363 scopus 로고    scopus 로고
    • Hormone selectivity in thyroid hormone receptors
    • Wagner RL et al. (2001) Hormone selectivity in thyroid hormone receptors. Mol Endocrinol 15: 398-410
    • (2001) Mol Endocrinol , vol.15 , pp. 398-410
    • Wagner, R.L.1
  • 36
    • 1942453725 scopus 로고    scopus 로고
    • Selective activation of thyroid hormone signaling pathways by GC-1: A new approach to controlling cholesterol and body weight
    • Baxter JD et al. (2004) Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight. Trends Endocrinol Metab 15: 154-157
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 154-157
    • Baxter, J.D.1
  • 37
    • 1642505721 scopus 로고    scopus 로고
    • Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: Selective actions relative to 3,5,3′-triiodo-L-thyronine
    • Grover GJ et al. (2004) Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3′-triiodo-L-thyronine. Endocrinology 145: 1656-1661
    • (2004) Endocrinology , vol.145 , pp. 1656-1661
    • Grover, G.J.1
  • 38
    • 17744387900 scopus 로고    scopus 로고
    • The thyroid hormone receptor-β- selective agonist GC-1 differentially affects plasma lipids and cardiac activity
    • Trost SU et al. (2000) The thyroid hormone receptor-β- selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology 141: 3057-3064
    • (2000) Endocrinology , vol.141 , pp. 3057-3064
    • Trost, S.U.1
  • 39
    • 0031781333 scopus 로고    scopus 로고
    • Effects of L-triiodothyronine and the thyromimetic L-94091 on serum lipoprotein levels and hepatic low density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression
    • Ness G et al. (1998) Effects of L-triiodothyronine and the thyromimetic L-94091 on serum lipoprotein levels and hepatic low density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression. Biochem Pharmacol 56: 121-129
    • (1998) Biochem Pharmacol , vol.56 , pp. 121-129
    • Ness, G.1
  • 40
    • 0141706620 scopus 로고    scopus 로고
    • Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2)
    • Shin DJ and Osborne TF (2003) Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2). J Biol Chem 278: 34114-34118
    • (2003) J Biol Chem , vol.278 , pp. 34114-34118
    • Shin, D.J.1    Osborne, T.F.2
  • 41
    • 0036229326 scopus 로고    scopus 로고
    • Thyroid disease and lipids
    • Duntas LH (2002) Thyroid disease and lipids. Thyroid 12: 287-293
    • (2002) Thyroid , vol.12 , pp. 287-293
    • Duntas, L.H.1
  • 42
    • 0842269844 scopus 로고    scopus 로고
    • Regulation of the human cholesterol 7α-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice
    • Drover VA and Agellon LB (2004) Regulation of the human cholesterol 7α-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice. Endocrinology 145: 574-581
    • (2004) Endocrinology , vol.145 , pp. 574-581
    • Drover, V.A.1    Agellon, L.B.2
  • 43
    • 22644432001 scopus 로고    scopus 로고
    • Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice
    • Johansson L et al. (2005) Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci USA 102: 10297-10302
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10297-10302
    • Johansson, L.1
  • 44
    • 33645463851 scopus 로고    scopus 로고
    • Endocrine disorders and cardiovascular disease
    • edn 7, Eds Zipes DP et al, Philadelphia: Elsevier Saunders
    • Klein I (2005) Endocrine disorders and cardiovascular disease. In Braunwald's Heart Disease, edn 7, 2051-2065 (Eds Zipes DP et al.) Philadelphia: Elsevier Saunders
    • (2005) Braunwald's Heart Disease , pp. 2051-2065
    • Klein, I.1
  • 45
    • 3142552579 scopus 로고    scopus 로고
    • Thyroid hormone and blood pressure regulation
    • Danzi S and Klein I (2003) Thyroid hormone and blood pressure regulation. Curr Hypertens Rep 5: 513-520
    • (2003) Curr Hypertens Rep , vol.5 , pp. 513-520
    • Danzi, S.1    Klein, I.2
  • 46
    • 0347927612 scopus 로고    scopus 로고
    • Low-T3 syndrome: A strong prognostic predictor of death in patients with heart disease
    • Iervasi G et al. (2003) Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation 107: 708-713
    • (2003) Circulation , vol.107 , pp. 708-713
    • Iervasi, G.1
  • 47
    • 4644357380 scopus 로고    scopus 로고
    • Thyroid hormone analog, DITPA, improves endothelial nitric oxide and β-adrenergic mediated vasorelaxation after myocardial infarction
    • Spooner PH et al. (2004) Thyroid hormone analog, DITPA, improves endothelial nitric oxide and β-adrenergic mediated vasorelaxation after myocardial infarction. J Cardiovasc Pharmacol 44: 453-459
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 453-459
    • Spooner, P.H.1
  • 48
    • 0030885926 scopus 로고    scopus 로고
    • 2+-ATPase and α-myosin heavy chain in rat hearts
    • 2+-ATPase and α-myosin heavy chain in rat hearts. J Clin Invest 100: 1742-1749
    • (1997) J Clin Invest , vol.100 , pp. 1742-1749
    • Chang, K.C.1
  • 49
    • 0030933656 scopus 로고    scopus 로고
    • The effects of a thyroid hormone analog on left ventricular performance and contractile and calcium cycling proteins in the baboon
    • Hoit BD et al. (1997) The effects of a thyroid hormone analog on left ventricular performance and contractile and calcium cycling proteins in the baboon. Proc Assoc Am Physicians 109: 136-145
    • (1997) Proc Assoc Am Physicians , vol.109 , pp. 136-145
    • Hoit, B.D.1
  • 50
    • 0021888704 scopus 로고
    • Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine
    • Silva JE and Leonard JL (1985) Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinology 116: 1627-1635
    • (1985) Endocrinology , vol.116 , pp. 1627-1635
    • Silva, J.E.1    Leonard, J.L.2
  • 51
    • 0031406558 scopus 로고    scopus 로고
    • Clinical and hormonal outcome after two years of triiodothyroacetic acid treatment in a child with thyroid hormone resistance
    • Radetti G et al. (1997) Clinical and hormonal outcome after two years of triiodothyroacetic acid treatment in a child with thyroid hormone resistance. Thyroid 7: 775-778
    • (1997) Thyroid , vol.7 , pp. 775-778
    • Radetti, G.1
  • 52
    • 0028915364 scopus 로고
    • Long term follow up of medical treatment of differentiated thyroid cancer
    • Jaffiol C et al. (1995) Long term follow up of medical treatment of differentiated thyroid cancer. Ann Endocrinol (Paris) 56: 119-126
    • (1995) Ann Endocrinol (Paris) , vol.56 , pp. 119-126
    • Jaffiol, C.1
  • 53
    • 10744220388 scopus 로고    scopus 로고
    • Comparative efficacy and side effects of the treatment of euthyroid goiter with levothyroxine or triiodothyroacetic acid
    • Brenta G et al. (2003) Comparative efficacy and side effects of the treatment of euthyroid goiter with levothyroxine or triiodothyroacetic acid. J Clin Endocrinol Metab 88: 5287-5292
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5287-5292
    • Brenta, G.1
  • 54
    • 18244364644 scopus 로고    scopus 로고
    • Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist
    • Baxter JD et al. (2002) Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology 143: 517-524
    • (2002) Endocrinology , vol.143 , pp. 517-524
    • Baxter, J.D.1
  • 55
    • 0033965389 scopus 로고    scopus 로고
    • Rational discovery of novel nuclear hormone receptor antagonists
    • Schapira M et al. (2000) Rational discovery of novel nuclear hormone receptor antagonists. Proc Natl Acad Sci USA 97: 1008-1013
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1008-1013
    • Schapira, M.1
  • 56
    • 0037130243 scopus 로고    scopus 로고
    • Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment
    • Nguyen NH et al. (2002) Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem 45: 3310-3320
    • (2002) J Med Chem , vol.45 , pp. 3310-3320
    • Nguyen, N.H.1
  • 57
    • 3042549120 scopus 로고    scopus 로고
    • Quantitative proteomics of the thyroid hormone receptor-coregulator interactions
    • Moore JMR et al. (2004) Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. J Biol Chem 279: 27584-27590
    • (2004) J Biol Chem , vol.279 , pp. 27584-27590
    • Moore, J.M.R.1
  • 58
    • 21244452633 scopus 로고    scopus 로고
    • Amiodarone and the thyroid
    • Basaria S and Cooper DS (2005) Amiodarone and the thyroid. Am J Med 118: 706-714
    • (2005) Am J Med , vol.118 , pp. 706-714
    • Basaria, S.1    Cooper, D.S.2
  • 59
    • 0042200747 scopus 로고    scopus 로고
    • The thermogenic effect of thyroid hormone and its clinical implications
    • Silva JE (2003) The thermogenic effect of thyroid hormone and its clinical implications. Ann Intern Med 139: 205-213
    • (2003) Ann Intern Med , vol.139 , pp. 205-213
    • Silva, J.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.