Oral toxicological studies of black soybean (Glycine max) hull extract: Acute studies in rats and mice, and chronic studies in mice

Food and Chemical Toxicology

Volumn 49, Issue 12, 2011, Pages 3272-3278

  Fukuda, Itsuko ^a   Tsutsui, Miki ^a   Yoshida, Tadashi ^b   Toda, Toshiya ^b   Tsuda, Takanori ^c   Ashida, Hitoshi ^a  

^a KOBE UNIVERSITY   (Japan)

^b WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases   (Japan)

^c CHUBU UNIVERSITY   (Japan)

Author keywords

Acute; Black soybean; Chronic; Glycine max; Toxicity

Indexed keywords

CHOLESTEROL; GLYCINE MAX EXTRACT; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ABDOMINAL FAT; ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHRONIC TOXICITY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; LD 50; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; RAT; SEX DIFFERENTIATION; SOYBEAN; TISSUE NECROSIS; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; ASIA; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LETHAL DOSE 50; MALE; MICE; MICE, INBRED C57BL; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SOYBEANS; TOXICITY TESTS, ACUTE; TOXICITY TESTS, CHRONIC;

GLYCINE MAX; MUS; RATTUS;

EID: 80054872640     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.09.022     Document Type: Article

References (15)

1. Bentivegna S.S., Whitney K.M. Subchronic 3-month oral toxicity study of grape seed and grape skin extracts. Food Chem. Toxicol. 2002, 40:1731-1743.
2. Chengelis C.P., Kirkpatrick J.B., Regan K.S., Radovsky A.E., Beck M.J., Morita O., Tamaki Y., Suzuki H. 28-Day oral (gavage) toxicity studies of green tea catechins prepared for beverages in rats. Food Chem. Toxicol. 2008, 46:978-989.
3. Décordé K., Teissèdre P.-L., Sutra T., Ventura E., Jean-Paul C., Rouanet J.-M. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers. Mol. Nutr. Food Res. 2009, 53:659-666.
4. Fujii H., Sun B., Nishioka H., Hirose A., Aruoma O.I. Evaluation of the safety and toxicity of the oligomerized polyphenol Oligonol. Food Chem. Toxicol. 2007, 45:378-387.
5. Hanamura T., Aoki H. Toxicological evaluation of polyphenol extract from Acerola (Malpighia emarginata DC.) fruit. J. Food Sci. 2008, 73:T55-61.
6. Isbrucker R.A., Edwards J.A., Wolz E., Davidovich A., Bausch J. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies. Food Chem. Toxicol. 2006, 44:636-650.
7. Isbrucker R.A., Edwards J.A., Wolz E., Davidovich A., Bausch J. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: teratogenicity and reproductive toxicity studies in rats. Food Chem. Toxicol. 2006, 44:651-661.
8. Kanamoto Y., Yamashita Y., Nanba F., Yoshida T., Tsuda T., Fukuda I., Nakamura-Tsuruta S., Ashida H. A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. J. Agric. Food Chem. 2011, (doi:10.1021/jf201471p).
9. Lambert J.D., Kennett M.J., Sang S., Reuhl K.R., Ju J., Yang C.S. Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. Food Chem. Toxicol. 2010, 48:409-416.
10. Omoni A.O., Aluko R.E. Soybean foods and their benefits: potential mechanisms of action. Nutr. Rev. 2005, 63:272-283.
11. Ray S., Bagchi D., Lim P.M., Bagchi M., Gross S.M., Kothari S.C., Preuss H.G., Stohs S.J. Acute and long-term safety evaluation of a novel IH636 grape seed proanthocyanidin extract. Res. Commun. Mol. Pathol. Pharmacol. 2001, 109:165-197.
12. Ray S.D., Parikh H., Hickey E., Bagchi M., Bagchi D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol. Cell. Biochem. 2001, 218:27-33.
13. Soulimani R., Younos C., Jarmouni-Idrissi S., Bousta D., Khallouki F., Laila A. Behavioral and pharmaco-toxicological study of Papaver rhoeas L. in mice. J. Ethnopharmacol. 2001, 74:265-274.
14. Tsuda T., Horio F., Uchida K., Aoki H., Osawa T. Dietary cyanidin 3-O-β-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J. Nutr. 2003, 133:2125-2130.
15. Yamakoshi J., Saito M., Kataoka S., Kikuchi M. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chem. Toxicol. 2002, 40:599-607.