Evaluation of dried blood spot sampling following cassette dosing in drug discovery

Bioanalysis

Volumn 3, Issue 20, 2011, Pages 2291-2302

  Liang, Xiaorong ^a   Yang, Lulu ^a   Berezhkovskiy, Leonid ^a   Liederer, Bianca ^a   Nguyen, Trung ^a   Jia, Wei ^a   Schweiger, Michelle ^a   Dean, Brian ^a   Deng, Yuzhong ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GNE A; GNE B; GNE C; GNE D; GNE E; GNE F; GNE G; MET KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; ASSAY; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DRIED BLOOD SPOT; DRUG HALF LIFE; DRUG SCREENING; DRUG STRUCTURE; HEMOLYSIS; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SCREENING TEST; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRIED BLOOD SPOT TESTING; DRUG EVALUATION, PRECLINICAL; HETEROCYCLIC COMPOUNDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 80054868171     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.11.205     Document Type: Article

References (14)

1. Barfield M, Spooner N, Lad R et al. Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 870, 32-37 (2008).
2. Li WK, Tse FLS. Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules. Biomed. Chromatogr. 24, 49-65 (2010).
3. Liang XR, Li YH, Barfield M et al. Study of dried blood spots technique for the determination of dextromethorphan and its metabolite dextrorphan in human whole blood by LC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 799-806 (2009).
4. Spooner N, Lad R, Barfield M. Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method. Anal. Chem. 81, 1557-1563 (2009).
5. Keevil BG. The analysis of dried blood spot samples using liquid chromatography tandem mass spectrometry. Clin. Biochem. 44, 110-118 (2011).
6. Guthrie R, Susi A. A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 32, 338-343 (1963).
7. Beaudette P, Bateman KP. Discovery stage pharmacokinetics using dried blood spots. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 809, 153-158 (2004). (Pubitemid 38998433)
8. Clark GT, Haynes JJ, Bayliss MAJ et al. Utilization of DBS within drug discovery: development of a serial microsampling pharmacokinetic study in mice. Bioanalysis 2, 1477-1488 (2010).
9. Liu GW, Patrone L, Snapp HM et al. Evaluating and defining sample preparation procedures for DBS LC-MS/MS assays. Bioanalysis 2, 1405-1414 (2010).
10. Smith NF, Hayes A, Nutley BP et al. Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice. Cancer Chemother. Pharmacol. 54, 475-486 (2004). (Pubitemid 40022243)
11. Smith NF, Raynaud FI, Workman P. The application of cassette dosing for pharmacokinetic screening in small-molecule cancer drug discovery. Mol. Cancer Ther. 6, 428-440 (2007). (Pubitemid 46332445)
12. He K, Qian MX, Wong H et al. N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations. J. Pharm. Sci. 97, 2568-2580 (2008).
13. Christ DD. Cassette dosing pharmacokinetics: valuable tool or flawed science? Drug Metab. Dispos. 29, 935-935 (2001).
14. Liederer BM, Berezhkovskiy LM, Dean BJ et al. Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3-fluoropiperidine-4-ylamino)-1H- pyrazolo[3,4-b ]pyridin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3- dihydropy ridazine-4-carboxamide, a novel MET kinase inhibitor. Xenobiotica 41, 327-339 (2011).