Clonal analysis of hepatitis B viruses among blood donors from Joinville, Brazil: Evidence of dual infections, intragenotype recombination and markers of risk for hepatocellular carcinoma

Journal of Medical Virology

Volumn 83, Issue 12, 2011, Pages 2103-2112

  Reis, Laura M W ^a   Soares, Marcelo A ^a,b   França, Paulo H ^c   Soares, Esmeralda A ^a   Bonvicino, Cibele R ^a,d  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF JOINVILLE REGION   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Disease progression; F141L; Intragenotype recombination; Pre S deletions; Transmitted drug resistance

Indexed keywords

ADEFOVIR; ANTIVIRUS AGENT; VIRUS DNA;

ANTIVIRAL RESISTANCE; ARTICLE; BLOOD DONOR; BRAZIL; CANCER RISK; DISEASE COURSE; DNA SEQUENCE; GENE DELETION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MIXED INFECTION; MOLECULAR EPIDEMIOLOGY; MOLECULAR PHYLOGENY; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SEQUENCE ANALYSIS; VIRUS RECOMBINATION;

ADULT; AGED; AGED, 80 AND OVER; BLOOD DONORS; BRAZIL; CARCINOMA, HEPATOCELLULAR; CLUSTER ANALYSIS; DISEASE PROGRESSION; DNA, VIRAL; GENE DELETION; GENETIC MARKERS; GENETIC VARIATION; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHYLOGENY; POLYMERASE CHAIN REACTION; PROTEIN PRECURSORS; PROTEIN S; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA;

HEPATITIS B VIRUS;

EID: 80054861918     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.22246     Document Type: Article

References (49)

1. Abdou Chekaraou M, Brichler S, Mansour W, Le Gal F, Garba A, Deny P, Gordien E. 2010. A novel hepatitis B virus (HBV) subgenotype D (D8) strain, resulting from recombination between genotypes D and E, is circulating in Niger along with HBV/E strains. J Gen Virol 91: 1609-1620.
2. Anisimova M, Gascuel O. 2006. Approximate likelihood-ratio test for branches: A fast, accurate, and powerful alternative. Syst Biol 55: 539-552.
3. Araujo NM, Mello FC, Yoshida CF, Niel C, Gomes SA. 2004. High proportion of subgroup A' (genotype A) among Brazilian isolates of Hepatitis B virus. Arch Virol 149: 1383-1395.
4. Becker CE, Mattos AA, Bogo MR, Branco F, Sitnik R, Kretzmann NA. 2010. Genotyping of hepatitis B virus in a cohort of patients evaluated in a hospital of Porto Alegre, South of Brazil. Arq Gastroenterol 47: 13-17.
5. Bertolini DA, Ribeiro PC, Lemos MF, Saraceni CP, Pinho JR. 2010. Characterization of a Hepatitis B virus strain in southwestern Parana, Brazil, presenting mutations previously associated with anti-HBs Resistance. Rev Inst Med Trop Sao Paulo 52: 25-30.
6. Bottecchia M, Madejon A, Puente S, Garcia-Samaniego J, Rivas P, Herrero D, Soriano V. 2011. Detection of hepatitis B virus genotype A3 and primary drug resistance mutations in African immigrants with chronic hepatitis B in Spain. J Antimicrob Chemother 66: 641-644.
7. Brasil. 2011a. Hepatites Virais no Brasil: Situação, Ações e Agenda. Brasília: Ministério da Saúde, pp 1-16.
8. Brasil. 2011b. Regulamento Técnico de Procedimentos Hemoterápicos. Ministério da Saúde.
9. Carrilho FJ, Moraes CR, Pinho JR, Mello IM, Bertolini DA, Lemos MF, Moreira RC, Bassit LC, Cardoso RA, Ribeiro-dos-Santos G, Da Silva LC. 2004. Hepatitis B virus infection in Haemodialysis Centres from Santa Catarina State, Southern Brazil. Predictive risk factors for infection and molecular epidemiology. BMC Public Health 4: 13.
10. Cuestas ML, Rivero CW, Minassian ML, Castillo AI, Gentile EA, Trinks J, Leon L, Daleoso G, Frider B, Lezama C, Galoppo M, Giacove G, Mathet VL, Oubina JR. 2010. Naturally occurring hepatitis B virus (HBV) variants with primary resistance to antiviral therapy and S-mutants with potential primary resistance to adefovir in Argentina. Antiviral Res 87: 74-77.
11. Curtis M, Zhu Y, Borroto-Esoda K. 2007. Hepatitis B virus containing the I233V mutation in the polymerase reverse-transcriptase domain remains sensitive to inhibition by adefovir. J Infect Dis 196: 1483-1486.
12. Deny P, Zoulim F. 2010. Hepatitis B virus: From diagnosis to treatment. Pathol Biol (Paris) 58: 245-253.
13. Fan YF, Lu CC, Chen WC, Yao WJ, Wang HC, Chang TT, Lei HY, Shiau AL, Su IJ. 2001. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology 33: 277-286.
14. Gomes-Gouvea MS, Soares MC, Bensabath G, de Carvalho-Mello IM, Brito EM, Souza OS, Queiroz AT, Carrilho FJ, Pinho JR. 2009. Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region. J Gen Virol 90: 2638-2643.
15. Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O. 2010. New algorithms and methods to estimate maximum-likelihood phylogenies: Assessing the performance of PhyML 3.0. Syst Biol 59: 307-321.
16. Haddad R, Martinelli Ade L, Uyemura SA, Yokosawa J. 2010. Hepatitis B virus genotyping among chronic hepatitis B patients with resistance to treatment with lamivudine in the City of Ribeirao Preto, State of Sao Paulo. Rev Soc Bras Med Trop 43: 224-228.
17. Hall TA. 1999. BioEdit: A user-friendly biological sequence alignment editor and analysis program for windows 95/98/NT. Nucleic Acids Symp Ser 41: 95-98.
18. Jutavijittum P, Jiviriyawat Y, Yousukh A, Kunachiwa W, Toriyama K. 2006. Genotypes of hepatitis B virus among voluntary blood donors in northern Thailand. Hepatol Res 35: 263-266.
19. Keane TM, Creevey CJ, Pentony MM, Naughton TJ, McLnerney JO. 2006. Assessment of methods for amino acid matrix selection and their use on empirical data shows that ad hoc assumptions for choice of matrix are not justified. BMC Evol Biol 6: 29.
20. Kurbanov F, Tanaka Y, Kramvis A, Simmonds P, Mizokami M. 2008. When should "I" consider a new hepatitis B virus genotype? J Virol 82: 8241-8242.
21. Kurbanov F, Tanaka Y, Mizokami M. 2010. Geographical and genetic diversity of the human hepatitis B virus. Hepatol Res 40: 14-30.
22. Lin CL, Kao JH. 2011. The clinical implications of hepatitis B virus genotype: Recent advances. J Gastroenterol Hepatol 26 (Suppl 1): 123-130.
23. Lin CL, Liu CH, Chen W, Huang WL, Chen PJ, Lai MY, Chen DS, Kao JH. 2007a. Association of pre-S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma. J Gastroenterol Hepatol 22: 1098-1103.
24. Lin CL, Liu CJ, Chen PJ, Lai MY, Chen DS, Kao JH. 2007b. High prevalence of occult hepatitis B virus infection in Taiwanese intravenous drug users. J Med Virol 79: 1674-1678.
25. Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, Ingersoll R, Sheppard HW, Ray SC. 1999. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol 73: 152-160.
26. Mello FC, Souto FJ, Nabuco LC, Villela-Nogueira CA, Coelho HS, Franz HC, Saraiva JC, Virgolino HA, Motta-Castro AR, Melo MM, Martins RM, Gomes SA. 2007. Hepatitis B virus genotypes circulating in Brazil: Molecular characterization of genotype F isolates. BMC Microbiol 7: 103.
27. Ministério da Saúde do Brasil. 2010. Boletim Epidemiológico das Hepatites Virais 2010. In: Departamento de DST Aids e Hepatites Virais, editor.
28. Mun HS, Lee SA, Kim H, Hwang ES, Kook YH, Kim BJ. 2011. Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections. J Virol 85: 123-132.
29. Olinger CM, Venard V, Njayou M, Oyefolu AO, Maiga I, Kemp AJ, Omilabu SA, le Faou A, Muller CP. 2006. Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: New subtypes, mixed infections and recombinations. J Gen Virol 87: 1163-1173.
30. Oon CJ, Chen WN, Koh S, Lim GK. 1999. Identification of hepatits B surface antigen variants with alterations outside the "a" determinant in immunized Singapore infants. J Infect Dis 179: 259-263.
31. Sanchez-Tapias JM, Costa J, Mas A, Bruguera M, Rodes J. 2002. Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients. Gastroenterology 123: 1848-1856.
32. Santos AO, Alvarado-Mora MV, Botelho L, Vieira DS, Pinho JR, Carrilho FJ, Honda ER, Salcedo JM. 2010. Characterization of hepatitis B virus (HBV) genotypes in patients from Rondonia, Brazil. Virol J 7: 315.
33. Schildgen O, Sirma H, Funk A, Olotu C, Wend UC, Hartmann H, Helm M, Rockstroh JK, Willems WR, Will H, Gerlich WH. 2006. Variant of hepatitis B virus with primary resistance to adefovir. N Engl J Med 354: 1807-1812.
34. Schutte K, Bornschein J, Malfertheiner P. 2009. Hepatocellular carcinoma-Epidemiological trends and risk factors. Dig Dis 27: 80-92.
35. Sharma S, Sharma B, Singla B, Chawla YK, Chakraborti A, Saini N, Duseja A, Das A, Dhiman RK. 2010. Clinical significance of genotypes and precore/basal core promoter mutations in HBV related chronic liver disease patients in North India. Dig Dis Sci 55: 794-802.
36. Shepard CW, Simard EP, Finelli L, Fiore AE, Bell BP. 2006. Hepatitis B virus infection: Epidemiology and vaccination. Epidemiol Rev 28: 112-125.
37. Simmonds P, Midgley S. 2005. Recombination in the genesis and evolution of hepatitis B virus genotypes. J Virol 79: 15467-15476.
38. Sugauchi F, Orito E, Ichida T, Kato H, Sakugawa H, Kakumu S, Ishida T, Chutaputti A, Lai CL, Ueda R, Miyakawa Y, Mizokami M. 2002. Hepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core gene. J Virol 76: 5985-5992.
39. Sugauchi F, Ohno T, Orito E, Sakugawa H, Ichida T, Komatsu M, Kuramitsu T, Ueda R, Miyakawa Y, Mizokami M. 2003a. Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease. J Med Virol 70: 537-544.
40. Sugauchi F, Orito E, Ichida T, Kato H, Sakugawa H, Kakumu S, Ishida T, Chutaputti A, Lai CL, Gish RG, Ueda R, Miyakawa Y, Mizokami M. 2003b. Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C. Gastroenterology 124: 925-932.
41. Sugauchi F, Kumada H, Sakugawa H, Komatsu M, Niitsuma H, Watanabe H, Akahane Y, Tokita H, Kato T, Tanaka Y, Orito E, Ueda R, Miyakawa Y, Mizokami M. 2004. Two subtypes of genotype B (Ba and Bj) of hepatitis B virus in Japan. Clin Infect Dis 38: 1222-1228.
42. Takahashi K, Akahane Y, Hino K, Ohta Y, Mishiro S. 1998. Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: Comparative analysis of 40 full-length isolates. Arch Virol 143: 2313-2326.
43. Tatematsu K, Tanaka Y, Kurbanov F, Sugauchi F, Mano S, Maeshiro T, Nakayoshi T, Wakuta M, Miyakawa Y, Mizokami M. 2009. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J. J Virol 83: 10538-10547.
44. Thakur V, Guptan RC, Kazim SN, Malhotra V, Sarin SK. 2002. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. J Gastroenterol Hepatol 17: 165-170.
45. Tonetto PA, Goncales NS, Fais VC, Vigani AG, Goncales ES, Feltrin A, Goncales FL Jr. 2009. Hepatitis B virus: Molecular genotypes and HBeAg serological status among HBV-infected patients in the southeast of Brazil. BMC Infect Dis 9: 149.
46. Trinks J, Cuestas ML, Tanaka Y, Mathet VL, Minassian ML, Rivero CW, Benetucci JA, Gimenez ED, Segura M, Bobillo MC, Corach D, Ghiringhelli PD, Sanchez DO, Avila MM, Peralta LA, Kurbanov F, Weissenbacher MC, Simmonds P, Mizokami M, Oubina JR. 2008. Two simultaneous hepatitis B virus epidemics among injecting drug users and men who have sex with men in Buenos Aires, Argentina: Characterization of the first D/A recombinant from the American continent. J Viral Hepat 15: 827-838.
47. Victoria Fda S, Oliveira CM, Victoria MB, Victoria CB, Ferreira LC. 2008. Characterization of HBeAg-negative chronic hepatitis B in western Brazilian Amazonia. Braz J Infect Dis 12: 27-37.
48. Xu Z, Liu Y, Xu T, Chen L, Si L, Wang Y, Ren X, Zhong Y, Zhao J, Xu D. 2010. Acute hepatitis B infection associated with drug-resistant hepatitis B virus. J Clin Virol 48: 270-274.
49. Yang HI, Yeh SH, Chen PJ, Iloeje UH, Jen CL, Su J, Wang LY, Lu SN, You SL, Chen DS, Liaw YF, Chen CJ. 2008. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 100: 1134-1143.