Association of pre-S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 7, 2007, Pages 1098-1103

  Lin, Chih Lin ^b   Liu, Chen Hua ^c   Chen, Wendy ^c   Huang, Wen Ling ^c   Chen, Pei Jer ^c   Lai, Ming Yang ^c   Chen, Ding Shinn ^c   Kao, Jia Horng ^a,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI CITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Genotype; Hepatitis B virus; Hepatocellular carcinoma; Pre S deletion mutant

Indexed keywords

VIRUS PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RISK; CONFIDENCE INTERVAL; CONTROLLED STUDY; DELETION MUTANT; FEMALE; GENOTYPE; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; VIRUS CARCINOGENESIS; VIRUS CARRIER; VIRUS MUTANT; VIRUS MUTATION;

EID: 84984550855     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04515.x     Document Type: Article

References (32)

1. Kao JH, Chen DS. Overview of hepatitis B and C viruses. In : Goedert JJ, ed. Infectious Causes of Cancer: Targets for Intervention. Totowa : Humana Press, 2000 313 30.
2. Lau JY, Wrigh TTL. Molecular virology and pathogenesis of hepatitis B. Lancet 1993 342 : 1335 40.
3. Norder H, Courouce AM, Magnius LO. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 1994 198 : 489 503.
4. Okamoto H, Tsuda F, Sakugawa H et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J. Gen. Virol. 1988 69 : 2575 83.
5. Stuyver L, De Gendt S, Van Geyt C et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J. Gen. Virol. 2000 81 : 67 74.
6. Arauz-ruiz P, Norder H, Robertson BH, Magnius LO. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J. Gen. Virol. 2002 83 : 2059 73.
7. Liu CJ, Kao JH, Chen PJ, Lai MY, Chen DS. Molecular epidemiology of hepatitis B viral serotypes and genotypes in Taiwan. J. Biomed. Sci. 2002 9 : 166 70.
8. Hunt CM, Mcgill JM, Allen MI, Condreay LD. Clinical relevance of hepatitis B viral mutations. Hepatology 2000 31 : 1037 44.
9. Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003 124 : 327 34.
10. Gerken G, Kremsdorf D, Capel F et al. Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection. Virology 1991 183 : 555 65.
11. Fernholz D, Stemler M, Brunetto M, Bonino F, Will H. Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein. J. Hepatol. 1991 13 : S102 S104.
12. Xu Z, Yen TSB. Intracellular retension of surface protein by a hepatitis B virus mutant that releases virion particles. J. Virol. 1996 70 : 133 40.
13. Fan YF, Lu CC, Chen WC et al. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology 2001 33 : 277 86.
14. Sugauchi F, Ohno T, Orito E et al. Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease. J. Med. Virol. 2003 70 : 537 44.
15. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000 118 : 554 9.
16. Kao JH, Chen PJ, Lai MY, Chen DS. Sequence analysis of pre-S/surface and pre-core/core promoter genes of hepatitis B virus in chronic hepatitis C patients with occult HBV infection. J. Med. Virol. 2002 68 : 216 20.
17. Chen BF, Kao JH, Liu CJ, Chen DS, Chen PJ. Genotypic dominance and novel recombinations in HBV genotype B and C co-infected intravenous drug users. J. Med. Virol. 2004 73 : 13 22.
18. Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J. Gastroenterol. Hepatol. 2002 17 : 643 50.
19. Santantonio T, Jung MC, Miska S et al. Prevalence and type of pre-C HBV mutants in anti-HBe positive carriers with chronic liver disease in a highly endemic area. Virology 1991 183 : 840 4.
20. Huy TT, Ushijima H, Win KM et al. High prevalence of hepatitis B virus pre-s mutant in countries where it is endemic and its relationship with genotype and chronicity. J. Clin. Microbiol. 2003 41 : 5449 55.
21. Preikschat P, Gunther S, Reinhold S et al. Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients. Hepatology 2002 35 : 466 77.
22. Blackberg J, Kidd-Ijunggren K. Mutations within the hepatitis B virus genome among chronic hepatitis B patients with hepatocellular carcinoma. J. Med. Virol. 2003 71 : 18 23.
23. Yu MW, Yeh SH, Chen PJ et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J. Natl Cancer. Inst. 2005 97 : 265 72.
24. Song BC, Kim H, Kim SH, Cha CY, Kook YH, Kim BJ. Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea. J. Med. Virol. 2005 75 : 13 19.
25. Wang HC, Wu HC, Chen CF, Fausto N, Lei HY, Su IJ. Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress. Am. J. Pathol. 2003 163 : 2441 9.
26. Hung JH, Su IJ, Lei HY et al. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J. Biol. Chem. 2004 279 : 46 84 92.
27. Wang HC, Chang WT, Chang WW et al. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 2005 41 : 761 70.
28. Kao JH, Chen DS. Recent research progress of hepatocellular carcinoma. J. Formos. Med. Assoc. 2002 101 : 239 48.
29. Chen PJ, Chen DS. Hepatitis B virus infection and hepatocellular carcinoma: molecular genetics and clinical perspectives. Semin. Liver Dis. 1999 19 : 253 62.
30. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 1995 13 : 29 60.
31. Milich DR, Jones JE, McLachlan A, Bitter G, Moriarty A, Hughes JL. Importance of subtype in the immune response to the pre-S2 region of the hepatitis B surface antigen. II. Synthetic Pre-S2 immunogen. J. Immunol. 1990 144 : 3544 51.
32. Kao JH, Chen PJ, Lai MY, Chen DS. Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection. J. Clin. Microbiol. 2002 40 : 1207 9.