Phenotype-difference oriented identification of molecular functions for diabetes progression in Goto-Kakizaki rat

2011 IEEE International Conference on Systems Biology, ISB 2011

Volumn , Issue , 2011, Pages 111-116

  Piao, Guanying ^a   Qian, Bangguo ^a   Saito, Shigeru ^b   Liu, Zhi Ping ^a   Zeng, Tao ^a   Wang, Yong ^c   Wu, Jiarui ^a   Zhou, Huarong ^a   Chen, Luonan ^a   Horimoto, Katsuhisa ^d  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b INFOCOM Corporation   (Japan)

^c CHINESE ACADEMY OF SCIENCES   (China)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

diabetes; Disease phenotype; disease progression; molecular signature; systems biology

Indexed keywords

DATA SETS; DISEASE PROGRESSION; MOLECULAR DATA; MOLECULAR FUNCTION; MOLECULAR LEVELS; MOLECULAR MECHANISM; MOLECULAR SIGNATURES; POSTERIORI; SYSTEMS BIOLOGY; WELL-COVERED;

BIOLOGY; GENE EXPRESSION;

RATS;

EID: 80054854408     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ISB.2011.6033130     Document Type: Conference Paper

References (18)

1. The Gene Ontology Consortium: "Gene ontology: tool for the unification of biology", Nat. Genet., 2000, 25, pp. 25-29.
2. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: "Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles", Proc. Natl. Acad. Sci. USA, 2005, 102, pp. 15545-15550.
3. Almon RP, DuBois DC, Lai W, Xue B, Nie J, Jusko WJ: "Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats", J. Endocrinology, 2009, 200, pp. 331-346.
4. Nishimura, D, "BioCarta", Biotech Software & Internet Report, 2001, 2(3), pp. 117-120.
5. Fisher RA., "Statistical Methods for Research Workers", 4th Edition", 1932, Oliver and Boyd, London.
6. Liu ZP, Wang Y, Zhang XS, Chen L: "Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains", BMC Syst. Biol., 2010, 4(Suppl 2), S11.
7. Weyer C, Bogardus C, Mott DM, Pratley RE: "The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus", J. Clin. Invest., 1999, 104, pp. 787-794.
8. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G: "Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity", Nature, 2004, 431, pp. 200-205.
9. Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M: "Musclespecific Pten deletion protects against insulin resistance and diabetes", Mol. Cell. Biol., 2005, 25, pp. 1135-1145.
10. Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB: "The CD28 signaling pathway regulates glucose metabolism", Immunity, 2002, 16, pp. 769-777.
11. Feng Z: "p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment", Cold Spring Harb Perspect Biol., 2010, 2, pp. a001057.
12. Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC: "Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 subunit of phosphoinositide 3-kinase", Proc. Natl. Acad. Sci. U S A, 2002, 99, pp. 419-424.
13. Hermeking H: "The 14-3-3 cancer connection", Nat. Rev. Cancer, 2003, 3, pp. 931-943.
14. Pers TH, Hansen NT, Lage K, Koefoed P, Dworzynski P, Miller ML, Flint TJ, Mellerup E, Dam H, Andreassen OA, Djurovic S, Melle I, Brglum AD, Werge T, Purcell S, Ferreira MA, Kouskoumvekaki I, Workman CT, Hansen T, Mors O, Brunak S: "Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes", Genet. Epidemiol., 2011, 10, pp. 1002/gepi.20580.
15. Holowachuk EW, Greer MK, Martin DR: "The complete sequence of the MHC class II chain RT.1D alpha u of the diabetic BB rat: mRNA levels of RT1. D alpha in lymphocytes", Nucleic Acids Res., 1987, 15, pp. 10551-10567.
16. Furman B, Ong WK, Pyne NJ: "Cyclic AMP signaling in pancreatic islets, Adv. Exp. Med. Biol., 2010, 654, pp. 281-304.
17. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G: "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt", Science, 1997, 278, pp. 687-689.
18. Mason EF, Rathmell JC: "Cell metabolism: an essential link between cell growth and apoptosis", Biochim. Biophys. Acta., 2011, 1813, pp. 645-654.