Circulating lipocalin 2 is associated with body fat distribution at baseline but is not an independent predictor of insulin resistance: The prospective Cyprus Metabolism Study

European Journal of Endocrinology

Volumn 165, Issue 5, 2011, Pages 805-812

  Liu, Xiaowen ^a   Hamnvik, Ole Petter R ^b   Petrou, Michael ^c   Gong, Huizhi ^a   Chamberland, John P ^a,e   Christophi, Costas A ^c,d   Kales, Stefanos N ^d   Christiani, David C ^d   Mantzoros, Christos S ^a,b,d,e  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CYPRUS UNIVERSITY OF TECHNOLOGY   (Cyprus)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; LEPTIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

ADULT; AGE DISTRIBUTION; ANTHROPOMETRY; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; BODY WEIGHT; CARDIOVASCULAR RISK; CIGARETTE SMOKING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSS-SECTIONAL STUDY; FEMALE; FOLLOW UP; HUMAN; INDEPENDENT VARIABLE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; PATIENT PARTICIPATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOM SAMPLE; SEX DIFFERENCE; WAIST HIP RATIO;

ACUTE-PHASE PROTEINS; ADOLESCENT; BIOLOGICAL MARKERS; BODY FAT DISTRIBUTION; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; CYPRUS; FOLLOW-UP STUDIES; HUMANS; INSULIN RESISTANCE; LIPOCALINS; MALE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS;

EID: 80054807703     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-11-0660     Document Type: Article

References (22)

1. Kjeldsen L, Johnsen AH, Sengelov H & Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. Journal of Biological Chemistry 1993 268 10425-10432. (Pubitemid 23150227)
2. Flower DR. The lipocalin protein family: structure and function. Biochemical Journal 1996 318 1-14. (Pubitemid 26283618)
3. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S & Aderem A. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004 432 917-921. (doi:10.1038/ nature03104)
4. Liu Q & Nilsen-Hamilton M. Identification of a new acute phase protein. Journal of Biological Chemistry 1995 270 22565-22570. (doi:10.1074/jbc.270.38.22565)
5. Jayaraman A, Roberts KA, Yoon J, Yarmush DM, Duan X, Lee K & Yarmush ML. Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1beta: a proteomic analysis. Biotechnology and Bioengineering 2005 91 502-515. (doi:10.1002/bit.20535)
6. Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL & Xu A. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clinical Chemistry 2007 53 34-41. (doi:10.1373/clinchem.2006.075614)
7. Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB & Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 2007 56 2533-2540. (doi:10.2337/db07-0007)
8. Law IK, Xu A, Lam KS, Berger T, Mak TW, Vanhoutte PM, Liu JT, Sweeney G, Zhou M, Yang B & Wang Y. Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes 2010 59 872-882. (doi:10.2337/db09-1541)
9. Guo H, Jin D, Zhang Y, Wright W, Bazuine M, Brockman DA, Bernlohr DA & Chen X. Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice. Diabetes 2010 59 1376-1385. (doi:10.2337/db09-1735)
10. Catalan V, Gomez-Ambrosi J, Rodriguez A, Ramirez B, Silva C, Rotellar F, Gil MJ, Cienfuegos JA, Salvador J & Fruhbeck G. Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans. Journal of Molecular Medicine 2009 87 803-813. (doi:10.1007/s00109-009-0486-8)
11. Wallenius V, Elias E, Bergstrom GM, Zetterberg H & Behre CJ. The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old Swedish men. Experimental and Clinical Endocrinology & Diabetes 2011 119 75-80. (doi:10.1055/s-0030-1265212)
12. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J & Devarajan P. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005 365 1231-1238. (doi:10.1016/S0140-6736(05) 74811-X)
13. Mori K & Nakao K. Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage. Kidney International 2007 71 967-970. (doi:10.1038/sj.ki.5002165)
14. Hamnvik OP, Liu X, Petrou M, Gong H, Chamberland JP, Kim EH, Christophi CA, Kales SN, Christiani DC & Mantzoros CS. Soluble leptin receptor and leptin are associated with baseline adiposity and metabolic risk factors, and predict adiposity, metabolic syndrome, and glucose levels at 2-year follow-up: the Cyprus Metabolism Prospective Cohort Study. Metabolism 2011 60 987-993. (doi:10.1016/j.metabol.2010.09.009)
15. Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K & Mantzoros CS. Leptin is an effective treatment for hypothalamic amenorrhea. PNAS 2011 108 6585-6590. (doi:10.1073/pnas.1015674108)
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 412-419. (doi:10.1007/BF00280883)
17. Jun LS, Siddall CP & Rosen ED. A minor role for lipocalin 2 in high fat diet-induced glucose intolerance. American Journal of Physiology. Endocrinology and Metabolism, 2011 In press. (doi:10.1152/ajpendo.00147.2011)
18. Corripio R, Gonzalez-Clemente JM, Perez-Sanchez J, Naf S, Gallart L, Nosas R, Vendrell J & Caixas A. Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2: a 2-year longitudinal study. European Journal of Endocrinology 2010 163 887-893. (doi:10.1530/EJE-10-0408)
19. Choi KM, Kim TN, Yoo HJ, Lee KW, Cho GJ, Hwang TG, Baik SH, Choi DS & Kim SM. Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women. Clinical Endocrinology 2009 70 569-574. (doi:10.1111/j.1365-2265. 2008.03374.x)
20. Koiou E, Tziomalos K, Katsikis I, Kandaraki EA, Kalaitzakis E, Delkos D, Vosnakis C & Panidis D. Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome. Gynecological Endocrinology, 2011. In press. (doi:10.3109/09513590.2011.588745)
21. Ingelsson E, Larson MG, Yin X, Wang TJ, Meigs JB, Lipinska I, Benjamin EJ, Keaney JF Jr & Vasan RS. Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample. Journal of Clinical Endocrinology and Metabolism 2008 93 3149-3157. (doi:10.1210/jc.2008-0207)
22. Franks PW, Brage S, Luan J, Ekelund U, Rahman M, Farooqi IS, Halsall I, O'Rahilly S & Wareham NJ. Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity. Obesity Research 2005 13 1476-1484. (doi:10.1038/oby.2005.178)