메뉴 건너뛰기




Volumn 119, Issue 4, 2011, Pages 760-771

Oxygen-glucose deprivation and interleukin-1α trigger the release of perlecan LG3 by cells of neurovascular unit

Author keywords

cerebral ischemia; interleukin 1 (IL 1); neurons; neurovascular unit; oxygen glucose deprivation; perlecan LG3

Indexed keywords

INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LAMININ GLOBULAR DOMAIN 3; PERLECAN; UNCLASSIFIED DRUG;

EID: 80054805066     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07484.x     Document Type: Article
Times cited : (27)

References (49)
  • 1
    • 58149376973 scopus 로고    scopus 로고
    • Maintaining blood-brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation
    • Al Ahmad A., Gassmann M., and, Ogunshola O. O., (2009) Maintaining blood-brain barrier integrity: pericytes perform better than astrocytes during prolonged oxygen deprivation. J. Cell. Physiol. 218, 612-622.
    • (2009) J. Cell. Physiol. , vol.218 , pp. 612-622
    • Al Ahmad, A.1    Gassmann, M.2    Ogunshola, O.O.3
  • 2
    • 80053561988 scopus 로고    scopus 로고
    • Perlecan domain v modulates astrogliosis in vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release
    • Published Online doi: 10.1002/glia.21227.
    • Al-Ahmad A. J., Lee B., Saini M., and, Bix G. J., (2011) Perlecan domain V modulates astrogliosis In vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release. Glia, Published Online doi: 10.1002/glia.21227.
    • (2011) Glia
    • Al-Ahmad, A.J.1    Lee, B.2    Saini, M.3    Bix, G.J.4
  • 4
    • 0028168503 scopus 로고
    • Blood-borne interleukin-1 alpha is transported across the endothelial blood-spinal cord barrier of mice
    • Banks W. A., Kastin A. J., and, Ehrensing C. A., (1994) Blood-borne interleukin-1 alpha is transported across the endothelial blood-spinal cord barrier of mice. J. Physiol. 479 (Pt 2), 257-264.
    • (1994) J. Physiol. , vol.479 , Issue.PART 2 , pp. 257-264
    • Banks, W.A.1    Kastin, A.J.2    Ehrensing, C.A.3
  • 5
    • 42949109152 scopus 로고    scopus 로고
    • Novel interactions of perlecan: Unraveling Perlecan's role in angiogenesis
    • DOI 10.1002/jemt.20562
    • Bix G., and, Iozzo R. V., (2008) Novel interactions of perlecan: unraveling perlecan's role in angiogenesis. Microsc. Res. Tech. 71, 339-348. (Pubitemid 351620856)
    • (2008) Microscopy Research and Technique , vol.71 , Issue.5 , pp. 339-348
    • Bix, G.1    Iozzo, R.V.2
  • 7
    • 34247330149 scopus 로고    scopus 로고
    • Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the α2β1-integrin receptor
    • DOI 10.1182/blood-2006-08-039925
    • Bix G., Iozzo R. A., Woodall B., Burrows M., McQuillan A., Campbell S., Fields G. B., and, Iozzo R. V., (2007) Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor. Blood 109, 3745-3748. (Pubitemid 46641724)
    • (2007) Blood , vol.109 , Issue.9 , pp. 3745-3748
    • Bix, G.1    Iozzo, R.A.2    Woodall, B.3    Burrows, M.4    McQuillan, A.5    Campbell, S.6    Fields, G.B.7    Iozzo, R.V.8
  • 9
    • 55249104973 scopus 로고    scopus 로고
    • Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
    • Cailhier J. F., Sirois I., Laplante P., et al. (2008) Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis. J. Biol. Chem. 283, 27220-27229.
    • (2008) J. Biol. Chem. , vol.283 , pp. 27220-27229
    • Cailhier, J.F.1    Sirois, I.2    Laplante, P.3
  • 10
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan P. H., (2001) Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21, 2-14. (Pubitemid 32036708)
    • (2001) Journal of Cerebral Blood Flow and Metabolism , vol.21 , Issue.1 , pp. 2-14
    • Chan, P.H.1
  • 11
    • 38949128498 scopus 로고    scopus 로고
    • Identification of circulating endorepellin LG3 fragment: Potential use as a serological biomarker for breast cancer
    • DOI 10.1002/prca.200780049
    • Chang J. W., Kang U. B., Kim D. H., Yi J. K., Lee J. W., Noh D. Y., Lee C., and, Yu M. H., (2008) Identification of circulating endorepellin LG3 fragment: Potential use as a serological biomarker for breast cancer. Proteomics Clin. Appl. 2, 23-32. (Pubitemid 351210913)
    • (2008) Proteomics - Clinical Applications , vol.2 , Issue.1 , pp. 23-32
    • Chang, J.W.1    Kang, U.-B.2    Kim, D.H.3    Yi, J.K.4    Lee, J.W.5    Noh, D.-Y.6    Lee, C.7    Yu, M.-H.8
  • 12
    • 0035940295 scopus 로고    scopus 로고
    • Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro
    • DOI 10.1016/S0165-3806(01)00220-6, PII S0165380601002206
    • Chow J., Ogunshola O., Fan S. Y., Li Y., Ment L. R., and, Madri J. A., (2001) Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro. Brain Res. Dev. Brain Res. 130, 123-132. (Pubitemid 32830980)
    • (2001) Developmental Brain Research , vol.130 , Issue.1 , pp. 123-132
    • Chow, J.1    Ogunshola, O.2    Fan, S.-Y.3    Li, Y.4    Ment, L.R.5    Madri, J.A.6
  • 13
    • 84855745250 scopus 로고    scopus 로고
    • Perlecan domain v induces vascular endothelial growth factor secretion in brain endothelial cells is driven through integrin α5β1 and ERK-dependent signaling pathways
    • (in press).
    • Clarke D., Lee B., Al Ahmad A., Parham C., Auckland L., Fertala A., Kahle M., and, Bix G., (2011) Perlecan domain V induces vascular endothelial growth factor secretion in brain endothelial cells is driven through integrin α5β1 and ERK-dependent signaling pathways. Blood, (in press).
    • (2011) Blood
    • Clarke, D.1    Lee, B.2    Al Ahmad, A.3    Parham, C.4    Auckland, L.5    Fertala, A.6    Kahle, M.7    Bix, G.8
  • 14
    • 0042182182 scopus 로고    scopus 로고
    • Preparation of astroycte, oligodendrocyte, and microglia cultures from primary rat cerebral cultures
    • in (Fedoroff S. and Richardson A. eds), Humana Press, Totowa, NJ.
    • Cole R., and, de Vellis J., (2001) Preparation of astroycte, oligodendrocyte, and microglia cultures from primary rat cerebral cultures, in Protocols for Neural Cell Culture (, Fedoroff S., and, Richardson A., eds), pp. 117-127. Humana Press, Totowa, NJ.
    • (2001) Protocols for Neural Cell Culture , pp. 117-127
    • Cole, R.1    De Vellis, J.2
  • 16
    • 77958193306 scopus 로고    scopus 로고
    • Compartmentalization from the outside: The extracellular matrix and functional microdomains in the brain
    • Dityatev A., Seidenbecher C. I., and, Schachner M., (2010) Compartmentalization from the outside: the extracellular matrix and functional microdomains in the brain. Trends Neurosci. 33, 503-512.
    • (2010) Trends Neurosci. , vol.33 , pp. 503-512
    • Dityatev, A.1    Seidenbecher, C.I.2    Schachner, M.3
  • 17
    • 0642280832 scopus 로고    scopus 로고
    • Isolation and characterization of cerebral microvascular pericytes
    • Dore-Duffy P., (2003) Isolation and characterization of cerebral microvascular pericytes. Methods Mol. Med. 89, 375-382.
    • (2003) Methods Mol. Med. , vol.89 , pp. 375-382
    • Dore-Duffy, P.1
  • 18
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • DOI 10.1016/S0301-0082(00)00068-X, PII S030100820000068X
    • Farkas E., and, Luiten P. G., (2001) Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64, 575-611. (Pubitemid 32304447)
    • (2001) Progress in Neurobiology , vol.64 , Issue.6 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.M.2
  • 19
    • 1842471192 scopus 로고    scopus 로고
    • Focal Cerebral Ischemia Induces Active Proteases That Degrade Microvascular Matrix
    • DOI 10.1161/01.STR.0000119383.76447.05
    • Fukuda S., Fini C. A., Mabuchi T., Koziol J. A., Eggleston L. L., Jr, and, del Zoppo G. J., (2004) Focal cerebral ischemia induces active proteases that degrade microvascular matrix. Stroke 35, 998-1004. (Pubitemid 38419817)
    • (2004) Stroke , vol.35 , Issue.4 , pp. 998-1004
    • Fukuda, S.1    Fini, C.A.2    Mabuchi, T.3    Koziol, J.A.4    Eggleston Jr., L.L.5    Del Zoppo, G.J.6
  • 20
    • 0032770311 scopus 로고    scopus 로고
    • Regulation of the heparan sulfate proteoglycan, perlecan, by injury and interleukin-1α
    • DOI 10.1046/j.1471-4159.1999.0730812.x
    • Garcia de Yebenes E., Ho A., Damani T., Fillit H., and, Blum M., (1999) Regulation of the heparan sulfate proteoglycan, perlecan, by injury and interleukin-1alpha. J. Neurochem. 73, 812-820. (Pubitemid 29339857)
    • (1999) Journal of Neurochemistry , vol.73 , Issue.2 , pp. 812-820
    • Garcia De Yebenes, E.1    Ho, A.2    Damani, T.3    Fillit, H.4    Blum, M.5
  • 21
    • 80055111110 scopus 로고    scopus 로고
    • Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device
    • Harris J., Lee H., Tu C. T., Cribbs D., Cotman C., and, Jeon N. L., (2007) Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device. J. Vis. Exp. 8, e305.
    • (2007) J. Vis. Exp. , vol.8
    • Harris, J.1    Lee, H.2    Tu, C.T.3    Cribbs, D.4    Cotman, C.5    Jeon, N.L.6
  • 22
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • DOI 10.1124/pr.57.2.4
    • Hawkins B. T., and, Davis T. P., (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57, 173-185. (Pubitemid 41043883)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 24
    • 0028226346 scopus 로고
    • Perlecan: A gem of a proteoglycan
    • DOI 10.1016/0945-053X(94)90183-X
    • Iozzo R. V., (1994) Perlecan: a gem of a proteoglycan. Matrix Biol. 14, 203-208. (Pubitemid 24136379)
    • (1994) Matrix Biology , vol.14 , Issue.3 , pp. 203-208
    • Iozzo, R.V.1
  • 25
    • 0031657808 scopus 로고    scopus 로고
    • Matrix proteoglycans: From molecular design to cellular function
    • DOI 10.1146/annurev.biochem.67.1.609
    • Iozzo R. V., (1998) Matrix proteoglycans: from molecular design to cellular function. Annu. Rev. Biochem. 67, 609-652. (Pubitemid 28411140)
    • (1998) Annual Review of Biochemistry , vol.67 , pp. 609-652
    • Iozzo, R.V.1
  • 26
    • 12344252444 scopus 로고    scopus 로고
    • Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia
    • DOI 10.1038/sj.cr.7290225, PII 7290225
    • Jones P. A., May G. R., McLuckie J. A., Iwashita A., and, Sharkey J., (2004) Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia. Cell Res. 14, 241-250. (Pubitemid 43231822)
    • (2004) Cell Research , vol.14 , Issue.3 , pp. 241-250
    • Jones, P.A.1    May, G.R.2    Mcluckie, J.A.3    Iwashita, A.4    Sharkey, J.5
  • 28
    • 33750057983 scopus 로고    scopus 로고
    • Perlecan proteolysis induces an α2β1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation
    • DOI 10.1074/jbc.M606412200
    • Laplante P., Raymond M. A., Labelle A., Abe J., Iozzo R. V., and, Hebert M. J., (2006) Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J. Biol. Chem. 281, 30383-30392. (Pubitemid 44582094)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.41 , pp. 30383-30392
    • Laplante, P.1    Raymond, M.-A.2    Labelle, A.3    Abe, J.-I.4    Iozzo, R.V.5    Hebert, M.-J.6
  • 29
    • 65549161030 scopus 로고    scopus 로고
    • VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells
    • Lee H. T., Chang Y. C., Tu Y. F., and, Huang C. C., (2009) VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells. J. Neurosci. 29, 4356-4368.
    • (2009) J. Neurosci. , vol.29 , pp. 4356-4368
    • Lee, H.T.1    Chang, Y.C.2    Tu, Y.F.3    Huang, C.C.4
  • 30
    • 79960988894 scopus 로고    scopus 로고
    • Perlecan domain v is neuroprotective and proangiogenic following ischemic stroke in rodents
    • Lee B., Clarke D., Al Ahmad A., et al. (2011) Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents. J. Clin. Invest. 121, 3005-3023.
    • (2011) J. Clin. Invest. , vol.121 , pp. 3005-3023
    • Lee, B.1    Clarke, D.2    Al Ahmad, A.3
  • 31
    • 0037423391 scopus 로고    scopus 로고
    • Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan
    • DOI 10.1074/jbc.M210445200
    • Mongiat M., Sweeney S. M., San Antonio J. D., Fu J., and, Iozzo R. V., (2003) Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J. Biol. Chem. 278, 4238-4249. (Pubitemid 36801161)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.6 , pp. 4238-4249
    • Mongiat, M.1    Sweeney, S.M.2    San Antonio, J.D.3    Fu, J.4    Iozzo, R.V.5
  • 32
    • 31844440672 scopus 로고    scopus 로고
    • Dual inhibition of protein phosphatase-1/2A and calpain rescues nerve growth factor-differentiated PC12 cells from oxygen-glucose deprivation-induced cell death
    • DOI 10.1002/jnr.20740
    • Nakajima T., Wakasa T., Okuma Y., Inanami O., Nomura Y., Kuwabara M., and, Kawahara K., (2006) Dual inhibition of protein phosphatase-1/2A and calpain rescues nerve growth factor-differentiated PC12 cells from oxygen-glucose deprivation-induced cell death. J. Neurosci. Res. 83, 459-468. (Pubitemid 43184409)
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.3 , pp. 459-468
    • Nakajima, T.1    Wakasa, T.2    Okuma, Y.3    Inanami, O.4    Nomura, Y.5    Kuwabara, M.6    Kawahara, K.7
  • 33
    • 0032079334 scopus 로고    scopus 로고
    • Extracellular space structure revealed by diffusion analysis
    • DOI 10.1016/S0166-2236(98)01261-2
    • Nicholson C., and, Sykova E., (1998) Extracellular space structure revealed by diffusion analysis. Trends Neurosci. 21, 207-215. (Pubitemid 28191815)
    • (1998) Trends in Neurosciences , vol.21 , Issue.5 , pp. 207-215
    • Nicholson, C.1    Sykova, E.2
  • 34
    • 0030606329 scopus 로고    scopus 로고
    • Purification and characterization of perlecan fragment in urine of end-stage renal failure patients
    • DOI 10.1016/0009-8981(96)06395-4, PII S0009898196063954
    • Oda O., Shinzato T., Ohbayashi K., Takai I., Kunimatsu M., Maeda K., and, Yamanaka N., (1996) Purification and characterization of perlecan fragment in urine of end-stage renal failure patients. Clin. Chim. Acta 255, 119-132. (Pubitemid 26374054)
    • (1996) Clinica Chimica Acta , vol.255 , Issue.2 , pp. 119-132
    • Oda, O.1    Shinzato, T.2    Ohbayashi, K.3    Takai, I.4    Kunimatsu, M.5    Maeda, K.6    Yamanaka, N.7
  • 35
    • 33645670658 scopus 로고    scopus 로고
    • Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
    • Premzl A., Turk V., and, Kos J., (2006) Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro. J. Cell. Biochem. 97, 1230-1240.
    • (2006) J. Cell. Biochem. , vol.97 , pp. 1230-1240
    • Premzl, A.1    Turk, V.2    Kos, J.3
  • 37
    • 0028024646 scopus 로고
    • Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells
    • DOI 10.1002/jcp.1041590114
    • Roux F., Durieu-Trautmann O., Chaverot N., Claire M., Mailly P., Bourre J. M., Strosberg A. D., and, Couraud P. O., (1994) Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J. Cell. Physiol. 159, 101-113. (Pubitemid 24234582)
    • (1994) Journal of Cellular Physiology , vol.159 , Issue.1 , pp. 101-113
    • Roux, F.1    Durieu-Trautmann, O.2    Chaverot, N.3    Claire, M.4    Mailly, P.5    Bourre, J.-M.6    Strosberg, A.D.7    Couraud, P.-O.8
  • 39
    • 0032551584 scopus 로고    scopus 로고
    • Distribution of perlecan in mouse hippocampus following intracerebroventricular kainate injections
    • DOI 10.1016/S0006-8993(98)00490-9, PII S0006899398004909
    • Shee W. L., Ong W. Y., and, Lim T. M., (1998) Distribution of perlecan in mouse hippocampus following intracerebroventricular kainate injections. Brain Res. 799, 292-300. (Pubitemid 28351260)
    • (1998) Brain Research , vol.799 , Issue.2 , pp. 292-300
    • Shee, W.L.1    Ong, W.Y.2    Lim, T.M.3
  • 40
    • 1042288482 scopus 로고    scopus 로고
    • Culture of murine brain microvascular endothelial cells that maintain expression and cytoskeletal association of tight junction-associated proteins
    • DOI 10.1290/1543-706X(2003)039<0313:COMBME>2.0.CO;2
    • Song L., and, Pachter J. S., (2003) Culture of murine brain microvascular endothelial cells that maintain expression and cytoskeletal association of tight junction-associated proteins. In Vitro Cell. Dev. Biol. Anim. 39, 313-320. (Pubitemid 38200254)
    • (2003) In Vitro Cellular and Developmental Biology - Animal , vol.39 , Issue.7 , pp. 313-320
    • Song, L.1    Pachter, J.S.2
  • 41
    • 77950972617 scopus 로고    scopus 로고
    • Epidermal growth factor and perlecan fragments produced by apoptotic endothelial cells co-ordinately activate ERK1/2-dependent antiapoptotic pathways in mesenchymal stem cells
    • Soulez M., Sirois I., Brassard N., Raymond M. A., Nicodeme F., Noiseux N., Durocher Y., Pshezhetsky A. V., and, Hebert M. J., (2010) Epidermal growth factor and perlecan fragments produced by apoptotic endothelial cells co-ordinately activate ERK1/2-dependent antiapoptotic pathways in mesenchymal stem cells. Stem Cells 28, 810-820.
    • (2010) Stem Cells , vol.28 , pp. 810-820
    • Soulez, M.1    Sirois, I.2    Brassard, N.3    Raymond, M.A.4    Nicodeme, F.5    Noiseux, N.6    Durocher, Y.7    Pshezhetsky, A.V.8    Hebert, M.J.9
  • 42
    • 0037424374 scopus 로고    scopus 로고
    • Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS
    • DOI 10.1016/S0014-2999(03)01371-2
    • Tauskela J. S., Mealing G., Comas T., Brunette E., Monette R., Small D. L., and, Morley P., (2003) Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS. Eur. J. Pharmacol. 464, 17-25. (Pubitemid 36205060)
    • (2003) European Journal of Pharmacology , vol.464 , Issue.1 , pp. 17-25
    • Tauskela, J.S.1    Mealing, G.2    Comas, T.3    Brunette, E.4    Monette, R.5    Small, D.L.6    Morley, P.7
  • 43
    • 37349072821 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity
    • DOI 10.1016/j.mcn.2007.09.002, PII S1044743107002138
    • Thornton P., Pinteaux E., Allan S. M., and, Rothwell N. J., (2008) Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity. Mol. Cell. Neurosci. 37, 135-142. (Pubitemid 350299999)
    • (2008) Molecular and Cellular Neuroscience , vol.37 , Issue.1 , pp. 135-142
    • Thornton, P.1    Pinteaux, E.2    Allan, S.M.3    Rothwell, N.J.4
  • 45
    • 77950405535 scopus 로고    scopus 로고
    • IL-1alpha and IL-1beta have different effects on formation and activity of large osteoclasts
    • Trebec-Reynolds D. P., Voronov I., Heersche J. N., and, Manolson M. F., (2010) IL-1alpha and IL-1beta have different effects on formation and activity of large osteoclasts. J. Cell. Biochem. 109, 975-982.
    • (2010) J. Cell. Biochem. , vol.109 , pp. 975-982
    • Trebec-Reynolds, D.P.1    Voronov, I.2    Heersche, J.N.3    Manolson, M.F.4
  • 46
    • 35648950527 scopus 로고    scopus 로고
    • Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteries
    • DOI 10.1007/s00221-007-1062-5
    • Vikman P., Ansar S., Henriksson M., Stenman E., and, Edvinsson L., (2007) Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Exp. Brain Res. 183, 499-510. (Pubitemid 350029365)
    • (2007) Experimental Brain Research , vol.183 , Issue.4 , pp. 499-510
    • Vikman, P.1    Ansar, S.2    Henriksson, M.3    Stenman, E.4    Edvinsson, L.5
  • 47
    • 0027099860 scopus 로고
    • Comparison of gene expression of extracellular matrix molecules in brain microvascular endothelial cells and astrocytes
    • DOI 10.1016/0006-291X(92)92285-6
    • Webersinke G., Bauer H., Amberger A., Zach O., and, Bauer H. C., (1992) Comparison of gene expression of extracellular matrix molecules in brain microvascular endothelial cells and astrocytes. Biochem. Biophys. Res. Commun. 189, 877-884. (Pubitemid 23032456)
    • (1992) Biochemical and Biophysical Research Communications , vol.189 , Issue.2 , pp. 877-884
    • Webersinke, G.1    Bauer, H.2    Amberger, A.3    Zach, O.4    Bauer, H.C.5
  • 49
    • 84861186060 scopus 로고    scopus 로고
    • Perlecan domain v inhibits alpha2 integrin-mediated amyloid-beta neurotoxicity
    • Published Online doi: 10.1016/j.neurobiolaging.2010.10.018.
    • Wright S., Parham C., Lee B., et al. (2010) Perlecan domain V inhibits alpha2 integrin-mediated amyloid-beta neurotoxicity. Neurobiol. Aging. Published Online doi: 10.1016/j.neurobiolaging.2010.10.018.
    • (2010) Neurobiol. Aging
    • Wright, S.1    Parham, C.2    Lee, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.