Decreased expression of angiotensin II type 1 and type 2 receptors in the brain after long-term administration of antihypertensive drugs in stroke-prone spontaneously hypertensive rat

Journal of Pharmacological Sciences

Volumn 106, Issue 4, 2008, Pages 663-666

  Nishida, Yayoi ^a   Takahashi, Yasuo ^a   Sugahara Kobayashi, Megumi ^a   Ishikawa, Kouichi ^a   Asai, Satoshi ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin II receptor; Antihypertensive drug; Brain

Indexed keywords

AMLODIPINE; AMLODIPINE BESYLATE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ENALAPRIL MALEATE; VALSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN STEM; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG EFFECT; HYPERTENSION; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; TISSUE DISTRIBUTION;

EID: 42349089636     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.SC0080027     Document Type: Article

References (15)

1. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII The angiotensin II receptors. Pharmacol Rev. 2000;52:415-472.
2. Siragy HM. The role of the AT2 receptor in hypertension. Am J Hypertens. 2000;13:62S-67S.
3. von Bohlen und Halbach O, Albrecht D. The CNS renin-angiotensin system. Cell Tissue Res. 2006;326:599-616.
4. Ando H, Jezova M, Zhou J, Saavedra JM. Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain. Ann N Y Acad Sci. 2004;1018:345-350.
5. McKinley MJ, McAllen RM, Pennington GL, Smardencas A, Weisinger RS, Oldfield BJ. Physiological actions of angiotensin II mediated by AT1 and AT2 receptors in the brain. Clin Exp Pharmacol Physiol Suppl. 1996;3:S99-S104.
6. Jöhren O, Inagami T, Saavedra JM. Localization of AT2 angiotensin II receptor gene expression in rat brain by in situ hybridization histochemistry. Brain Res Mol Brain Res. 1996;37:192-200.
7. 2 receptors: cardiovascular hope or hype. Br J Pharmacol. 2003;140:809-824.
8. Nishida Y, Nagata T, Takahashi Y, Sugahara-Kobayashi M, Murata A, Asai S. Alteration of serum /glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Brain Res Mol Brain Res. 2004;123:121-125.
9. Takahashi Y, Ishii Y, Nishida Y, Ikarashi M, Nagata T, Nakamura T, et al. Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. Cancer Genet Cytogenet. 2006;168:30-35.
10. Takahashi Y, Masuda H, Ishii Y, Nishida Y, Kobayashi M, Asai S. Decreased expression of thioredoxin interacting protein mRNA in inflamed colonic mucosa in patients with ulcerative colitis. Oncol Rep. 2007;18:531-535.
11. Zhang X, Hintze TH. Amlodipine releases nitric oxide from canine coronary microvessels: an unexpected mechanism of action of a calcium channel-blocking agent. Circulation. 1998;97:576-580.
12. Inada Y, Wada T, Ojima M, Sanada T, Shibouta Y, Kanagawa R, et al. Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1997;19:1079-1099.
13. Kishida M, Otsuka F, Ogura T, Kataoka H, Nakamura Y, Yamauchi T, et al. Chronic treatment with amlodipine modulates adrenocortical angiotensin II receptors in spontaneously hypertensive rats. Life Sci. 2001;69:113-122.
14. Li JM, Mogi M, Tsukuda K, Tomochika H, Iwanami J, Min LJ, et al. Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Mol Endocrinol. 2007;21:499-511.
15. Mogi M, Li JM, Iwanami J, Min LJ, Tsukuda K, Iwai M, et al. Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2. Hypertension. 2006;48:141-148.