Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 42, 2011, Pages 17349-17354

  Geh, Esmond ^a   Meng, Qinghang ^a   Mongan, Maureen ^a   Wang, Jingcai ^a,b   Takatori, Atsushi ^c   Zheng, Yi ^d   Puga, Alvaro ^a   Lang, Richard A ^a,d   Xia, Ying ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c CHIBA CANCER CENTER   (Japan)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEIN C JUN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; EPITHELIUM; EYE DEVELOPMENT; EYELID CLOSURE; GENE INACTIVATION; GENE INDUCTION; HEMIZYGOTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANIMALS; EYELIDS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MAP KINASE KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTOR, EPIDERMAL GROWTH FACTOR; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 80054794450     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1102297108     Document Type: Article

References (31)

1. Davis RJ (1995) Transcriptional regulation by MAP kinases. Mol Reprod Dev 42:459-467.
2. Geh GN, Jin C, Xia Y (2010) Map3k1. UCSD Nature Molecular Pages. Available at http://www.signaling-gateway.org/molecule/query?afcsid=A001512.
3. Xia Y, Karin M (2004) The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol 14(2):94-101. (Pubitemid 38186643)
4. Findlater GS, McDougall RD, Kaufman MH (1993) Eyelid development, fusion and subsequent reopening in the mouse. J Anat 183(1):121-129. (Pubitemid 23272424)
5. Luetteke NC, et al. (1993) TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73:263-278. (Pubitemid 23123306)
6. Mine N, Iwamoto R, Mekada E (2005) HB-EGF promotes epithelial cell migration in eyelid development. Development 132:4317-4326. (Pubitemid 41576693)
7. Huang J, et al. (2009) FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development 136:1741-1750.
8. Gage PJ, Qian M, Wu D, Rosenberg KI (2008) The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol 317:310-324.
9. Zhang L, et al. (2003) A role for MEK kinase 1 in TGF-beta/activin- induced epithelium movement and embryonic eyelid closure. EMBO J 22:4443-4454. (Pubitemid 37087198)
10. Takatori A, et al. (2008) Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development 135(1):23-32. (Pubitemid 351201478)
11. Naoe H, et al. (2010) The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol Cell Biol 30:3994-4005.
12. Thumkeo D, Shimizu Y, Sakamoto S, Yamada S, Narumiya S (2005) ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo. Genes Cells 10:825-834. (Pubitemid 41158741)
13. Li G, et al. (2003) c-Jun is essential for organization of the epidermal leading edge. Dev Cell 4:865-877. (Pubitemid 36676038)
14. Zenz R, et al. (2003) c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev Cell 4:879-889. (Pubitemid 36676039)
15. Uda M, et al. (2004) Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 13:1171-1181. (Pubitemid 38786999)
16. McHenry JZ, Leon A, Matthaei KI, Cohen DR (1998) Overexpression of fra-2 in transgenic mice perturbs normal eye development. Oncogene 17:1131-1140. (Pubitemid 28444597)
17. Yu Z, et al. (2008) Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure. Dev Biol 319(1):56-67.
18. Yujiri T, et al. (2000) MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci USA 97:7272-7277. (Pubitemid 30431453)
19. Xia Y, et al. (2000) MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci USA 97:5243-5248. (Pubitemid 30313703)
20. Fujii S, Hatakenaka N, Kaneda M, Teramoto S (1995) Morphogenetic study of the eyelids in NC-eob mice fetuses with an open-eyelid malformation at birth. Lab Anim Sci 45(2):176-180.
21. Tao H, Ono K, Kurose H, Noji S, Ohuchi H (2006) Exogenous FGF10 can rescue an eye-open at birth phenotype of Fgf10-null mice by activating activin and TGFalpha-EGFR signaling. Dev Growth Differ 48:339-346. (Pubitemid 43829479)
22. Vassalli A, Matzuk MM, Gardner HA, Lee KF, Jaenisch R (1994) Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev 8:414-427.
23. Samarakoon R, Higgins CE, Higgins SP, Higgins PJ (2009) Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption. Cell Signal 21:986-995.
24. Ashery-Padan R, Marquardt T, Zhou X, Gruss P (2000) Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev 14:2701-2711. (Pubitemid 32531197)
25. Vettese-Dadey M, et al. (1996) Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. EMBO J 15:2508-2518. (Pubitemid 26151190)
26. Gallagher ED, Gutowski S, Sternweis PC, Cobb MH (2004) RhoA binds to the amino-terminus of MEKK1 and regulates its kinase activity. J Biol Chem 279:1872-1877. (Pubitemid 38084456)
27. Marinissen MJ, et al. (2004) The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell 14(1):29-41. (Pubitemid 38469907)
28. Radler-Pohl A, et al. (1993) The activation and activity control of AP-1 (fos/jun). Ann N Y Acad Sci 684:127-148. (Pubitemid 23218947)
29. Weston CR, et al. (2003) JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev 17:1271-1280. (Pubitemid 36583169)
30. Providence KM, Higgins PJ (2004) PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair. J Cell Physiol 200:297-308. (Pubitemid 38880213)
31. Behrens A, Sibilia M, Wagner EF (1999) Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 21:326-329. (Pubitemid 29124945)