Exogenous FGF10 can rescue an eye-open at birth phenotype of Fgf10-null mice by activating activin and TGFα-EGFR signaling

Development Growth and Differentiation

Volumn 48, Issue 5, 2006, Pages 339-346

  Tao, Hirotaka ^a   Ono, Katsuhiko ^b   Kurose, Hitomi ^a   Noji, Sumihare ^a   Ohuchi, Hideyo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Eyelid closure; Fgf10; Filopodia; Mouse; Organ culture

Indexed keywords

ACTIVIN; EPIDERMAL GROWTH FACTOR RECEPTOR; F ACTIN; FIBROBLAST GROWTH FACTOR 10; MYELOPID; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; EMBRYO DEVELOPMENT; EXPLANT; EYELID; EYELID CLOSURE; FILOPODIUM; GENE EXPRESSION; KNOCKOUT MOUSE; MORPHOGENESIS; MOUSE; NONHUMAN; NULL ALLELE; PHENOTYPE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTINS; ACTIVINS; ANIMALS; EPITHELIAL CELLS; EYELIDS; FEMALE; FETUS; FIBROBLAST GROWTH FACTOR 10; HEDGEHOG PROTEINS; MALE; MICE; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; PHENOTYPE; PSEUDOPODIA; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 33744797658     PISSN: 00121592     EISSN: 1440169X     Source Type: Journal    
DOI: 10.1111/j.1440-169X.2006.00869.x     Document Type: Article

References (30)

1. De Moerlooze L. Spencer-Dene B. Revest J. Hajihosseini M. Rosewell I. Dickson C. 2000. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 127, 483 492.
2. Findlater G. S. McDougall R. D. Kaufman M. H. 1993. Eyelid development, fusion and subsequent reopening in the mouse. J. Anat. 183, 121 129.
3. Grose R. Dickson C. 2005. Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev. 16, 179 186.
4. Huang C. Rajfur Z. Borchers C. Schaller M. D. Jacobson K. 2003. JNK phosphorylates paxillin and regulates cell migration. Nature 424, 219 223.
5. Igarashi M. Finch P. W. Aaronson S. A. 1998. Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J. Biol. Chem. 273, 13 230 13 235.
6. Itoh N. Ornitz D. M. 2004. Evolution of the Fgf and Fgfr gene families. Trends Genet. 20, 563 569.
7. Jacinto A. Wood W. Woolner S. et al. 2002. Dynamic analysis of actin cable function during Drosophila dorsal closure. Curr. Biol. 12, 1245 1250.
8. Kayali A. G. Stotland A. Gunst K. V. et al. 2005. Growth factor-induced signaling of the pancreatic epithelium. J. Endocrinol. 185, 45 56.
9. Li C. Guo H. Xu X. Weinberg W. Deng C. X. 2001. Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning. Dev. Dyn. 222, 471 483.
10. Liu H. Mohamed O. Dufort D. Wallace V. A. 2003. Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Dev. Dyn. 227, 323 334.
11. Luetteke N. C. Qiu T. H. Peiffer R. L. Oliver P. Smithies O. Lee D. C. 1993. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73, 263 278.
12. Makarenkova H. P. Ito M. Govindarajan V. et al. 2000. FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127, 2563 2572.
13. Mann G. B. Fowler K. J. Gabriel A. Nice E. C. Williams R. L. Dunn A. R. 1993. Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73, 249 261.
14. Martin P. Parkhurst S. M. 2004. Parallels between repair and embryo morphogenesis. Development 131, 3021 3034.
15. Miettinen P. J. Berger J. E. Meneses J. et al. 1995. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376, 337 341.
16. Miettinen P. J. Chin J. R. Shum L. et al. 1999. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nat. Genet. 22, 69 73.
17. Mine N. Iwamoto R. Mekada E. 2005. HB-EGF promotes epithelial cell migration in eyelid development. Development 132, 4317 4326.
18. Motoyama J. Heng H. Crackower M. A. et al. 1998. Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis. Mech. Dev. 78, 81 84.
19. Ohuchi H. Hori Y. Yamasaki M. et al. 2000. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem. Biophys. Res. Commun. 277, 643 649.
20. Riedy M. C. Brown M. C. Molloy C. J. Turner C. E. 1999. Activin A and TGF-beta stimulate phosphorylation of focal adhesion proteins and cytoskeletal reorganization in rat aortic smooth muscle cells. Exp. Cell Res. 251, 194 202.
21. Sekine K. Ohuchi H. Fujiwara M. et al. 1999. Fgf10 is essential for limb and lung formation. Nat. Genet. 21, 138 141.
22. Taniguchi F. Harada T. Sakamoto Y. et al. 2003. Activation of mitogen-activated protein kinase pathway by keratinocyte growth factor or fibroblast growth factor-10 promotes cell proliferation in human endometrial carcinoma cells. J. Clin. Endocrinol. Metab. 88, 773 780.
23. Tao H. Shimizu M. Kusumoto R. Ono K. Noji S. Ohuchi H. 2005. A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. Development 132, 3217 3230.
24. Theodorou V. Boer M. Weigelt B. Jonkers J. van der Valk M. Hilkens J. 2004. Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas. Oncogene 23, 6047 6055.
25. Threadgill D. W. Dlugosz A. A. Hansen L. A. et al. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269, 230 234.
26. Upadhyay D. Lecuona E. Comellas A. Kamp D. W. Sznajder J. I. 2003. Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway. FEBS Lett. 545, 173 176.
27. Vassalli A. Matzuk M. M. Gardner H. A. Lee K. F. Jaenisch R. 1994. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 8, 414 427.
28. Xia Y. Karin M. 2004. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol. 14, 94 101.
29. Zenz R. Scheuch H. Martin P. et al. 2003. c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev. Cell 4, 879 889.
30. Zhang L. Wang W. Hayashi Y. et al. 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 22, 4443 4454.