Susceptibility of Porcine Keratocytes to Immune-Mediated Damage in Xeno-Related Rejection

Transplantation Proceedings

Volumn 40, Issue 2, 2008, Pages 564-569

  Kim, M K ^a,b   Oh, J Y ^a,b   Lee, H I ^c   Ko, J H ^b   Lee, H J ^b   Lee, J H ^a,b   Wee, W R ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University Biomedical Research Institute   (South Korea)

^c GM Eye Clinic   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIBODY; INTERLEUKIN 2;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHROMIUM 51 RELEASE; COMPLEMENT DEPOSITION; CONTROLLED STUDY; CORNEA CELL; CORNEA ENDOTHELIUM; CORNEA TRANSPLANTATION; ENDOTHELIUM CELL; FLOW CYTOMETRY; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RANK SUM TEST; SERUM; XENOGRAFT;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CELLS, CULTURED; CORNEA; CORNEAL TRANSPLANTATION; DNA PRIMERS; ENDOTHELIAL CELLS; ENDOTHELINS; GRAFT REJECTION; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; TRANSPLANTATION, HETEROLOGOUS; VIMENTIN;

EID: 40949092747     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2007.12.024     Document Type: Article

References (16)

1. Streilein J.W. Immune response and the eye. Chem Immunol. 1st Ed. (1999), Karger, Basel 11
2. Amano S., Shimomura N., Kaji Y., et al. Antigenicity of porcine cornea as xenograft. Curr Eye Res 26 (2003) 313
3. Theobald V.A., Lauer J.D., Kaplan F.A., et al. Neutral allografts lack of allogeneic stimulation by cultured human cells expressing MHC class I and class II antigens. Transplantation 55 (1993) 128
4. Foulks G.N. Diagnosis and management of corneal allograft rejection. Cornea. 2nd Ed. (2005), Elsevier Mosby, Philadelphia 1541
5. He Y.G., and Niederkorn J.Y. Depletion of donor-derived Langerhans cells promotes corneal allograft survival. Cornea 15 (1996) 82
6. Qian Y., and Dana M.R. Molecular mechanisms of immunity in corneal allotransplantation and xenotransplantation. Expert Rev Mol Med 16 (2001) 1
7. Pindjakova J., Vitova A., Krulova M., et al. Corneal rat-to-mouse xenotransplantation and the effects of anti-CD4 or anti-CD8 treatment on cytokine and nitric oxide production. Transpl Int 18 (2005) 854
8. Higuchi R., and Streilein J.W. CD8+ T cell-mediated delayed rejection of orthotopic guinea pig cornea grafts in mice deficient in CD4+ T cells. Invest Ophthalmol Vis Sci 44 (2003) 175
9. Tanaka K., Yamagami S., and Streilein J.W. Evidence that T-helper type 2 cell-derived cytokines and eosinophils contribute to acute rejection of orthotopic corneal xenografts in mice. Transplantation 79 (2005) 1317
10. Tanaka K., Yamada J., and Streilein J.W. Xenoreactive CD4+ T cells and acute rejection of orthotopic guinea pig corneas in mice. Invest Ophthalmol Vis Sci 41 (2000) 1827
11. Bordet J. Complement. The Immune Response (2006), Elsevier, San Diego 553
12. Mondino B.J., Sundar-Raj C.V., and Brady K.J. Production of first component of complement by corneal fibroblasts in tissue culture. Arch Ophthalmol 100 (1982) 478
13. Quantock A.J., Sano Y., Young R.D., et al. Stromal architecture and immune tolerance in additive corneal xenografts in rodents. Acta Ophthalmol Scand 83 (2005) 462
14. Ohno K., Mitooka K., Nelson L.R., et al. Keratocyte activation and apoptosis in transplanted human corneas in a xenograft model. Invest Ophthalmol Vis Sci 43 (2002) 1025
15. Chen G., Sun H., Yang H., et al. The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy. Transplantation 81 (2006) 273
16. Chen G., Qian H., Starzl T., et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 11 (2005) 1295