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Volumn 21, Issue 21, 2011, Pages 6485-6490

Discovery of novel cobactin-t based matrix metalloproteinase inhibitors via a ring closing metathesis strategy

Author keywords

Closing; Cobactin T; Matrix; Metalloproteinases; Metathesis; MMP 2 MMP 9; Ring

Indexed keywords

COBACTIN T; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE INHIBITOR; NATURAL PRODUCT; SULFONAMIDE; UNCLASSIFIED DRUG;

EID: 80054782178     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.068     Document Type: Article
Times cited : (10)

References (17)
  • 17
    • 85030493125 scopus 로고    scopus 로고
    • Experiments with in vitro ADME-Tox assays for 16 and 34 are as follows: hERG binding: < 50% @ 10 lM; CYP450 inhibition 3A4 2D6 < 50% @ 1 lM; AMES II = non-mutageneic; CEREP 50 targets: < 50% @ 10 lM
    • Experiments with in vitro ADME-Tox assays for 16 and 34 are as follows: hERG binding: < 50% @ 10 lM; CYP450 inhibition (3A4, 2D6) < 50% @ 1 lM; AMES II = non-mutageneic; CEREP 50 targets: < 50% @ 10 lM. This program was discontinued due to business reasons.
    • This program was discontinued due to business reasons


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.