Discovery of pyrazoles as novel FPR1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6456-6460

  Morley, Andrew D ^a   Cook, Andrew ^a   King, Sarah ^a   Roberts, Bryan ^a   Lever, Sarah ^a   Weaver, Richard ^b   MacDonald, Cathy ^b   Unitt, John ^c   Fagura, Malbinder ^c   Phillips, Tim ^c   Lewis, Richard ^a   Wenlock, Mark ^a  

^a ASTRAZENECA   (United Kingdom)

^b BioScience ^*  (United Kingdom)

^c Bioscience   (United Kingdom)

Author keywords

FPR1 antagonist; Hit to lead; Small molecule

Indexed keywords

PYRAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG POTENCY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOUSE; NEUTROPHIL; NONHUMAN; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION;

EID: 80054777555     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.085     Document Type: Article

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