Discovery of small molecule human FPR1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2991-2997

  Unitt, John ^a   Fagura, Malbinder ^a   Phillips, Tim ^a   King, Sarah ^c   Perry, Matthew ^c   Morley, Andrew ^c   MacDonald, Cathy ^b   Weaver, Richard ^b   Christie, Jadeen ^c   Barber, Simon ^c   Mohammed, Rukhsana ^c   Paul, Melanie ^c   Cook, Andrew ^c   Baxter, Andrew ^c  

^a ASTRAZENECA   (United Kingdom)

^b Discovery DMPK   (United Kingdom)

^c Medicinal Chemistry   (United Kingdom)

Author keywords

FPR1 antagonist; Hit to lead; Small molecule

Indexed keywords

BENZIMIDAZOLE; DIAMIDE; FORMYLPEPTIDE RECEPTOR; FORMYLPEPTIDE RECEPTOR 1; FORMYLPEPTIDE RECEPTOR 1 ANTAGONIST; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG INHIBITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; NEUTROPHIL; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

DRUG DISCOVERY; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, FORMYL PEPTIDE;

EID: 79955564710     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.049     Document Type: Article

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