MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - A common event amongst DNA-repair-deficient colorectal cancers

Journal of Pathology

Volumn 219, Issue 1, 2009, Pages 69-76

  De Miranda, Noel F C C ^a   Nielsen, Maartje ^a   Pereira, Dina ^a   Van Puijenbroek, Marjo ^a   Vasen, Hans F ^a   Hes, Frederik J ^a   Van Wezel, Tom ^a   Morreau, Hans ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Colorectal cancer; DNA repair; HLA class I; Immune evasion; Immune selection; MAP; MUTYH

Indexed keywords

ANTIGEN PROCESSING MACHINERY MOLECULE; BETA 2 MICROGLOBULIN; CARRIER PROTEIN; HLA ANTIGEN CLASS 1; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 2; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; METASTASIS; MISMATCH REPAIR; MUTYH ASSOCIATED POLYPOSIS; PHENOTYPE; PRIORITY JOURNAL;

ADULT; ANTIGEN PRESENTATION; ATP-BINDING CASSETTE TRANSPORTERS; BETA 2-MICROGLOBULIN; CARCINOMA; COLORECTAL NEOPLASMS; DNA GLYCOSYLASES; DNA REPAIR; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MHC CLASS I; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MIDDLE AGED; MUTATION; SEQUENCE ANALYSIS, DNA;

EID: 68849119061     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2569     Document Type: Article

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