Meta-analysis of controlled studies on immunotherapy in severe scorpion envenomation

Emergency Medicine Journal

Volumn 28, Issue 11, 2011, Pages 963-969

  Abroug, Fekri ^a   Ouanes Besbes, Lamia ^a   Ouanes, Islem ^a   Dachraoui, Fahmi ^a   Hassen, Mohamed Fkih ^b   Haguiga, Habib ^c   Elatrous, Souheil ^b   Brun Buisson, Christian ^d  

^a Intensive Care Unit   (Tunisia)

^b UNIVERSITY OF MONASTIR   (Tunisia)

^c Hôpital Régional   (Tunisia)

^d UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

SCORPION VENOM; VENOM ANTISERUM;

ANAPHYLACTIC SHOCK; ARTICLE; CONTROLLED CLINICAL TRIAL (TOPIC); DIARRHEA; ENVENOMATION; HUMAN; IMMUNOTHERAPY; META ANALYSIS; MORTALITY; OUTCOMES RESEARCH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCORPION; SERUM SICKNESS; SYSTEMATIC REVIEW; VOMITING;

ANIMALS; ANTIVENINS; ARACHNIDISM; CONTROLLED CLINICAL TRIALS AS TOPIC; HUMANS; IMMUNOTHERAPY; INJECTIONS, INTRAVENOUS; PROSPECTIVE STUDIES; SCORPION VENOMS; SCORPIONS;

EID: 80054771941     PISSN: 14720205     EISSN: 14720213     Source Type: Journal    
DOI: 10.1136/emj.2010.104158     Document Type: Article

References (45)

1. Chippaux JP, Goyffon M. Epidemiology of scorpionism: a global appraisal. Acta Trop 2008;107:71-9.
2. Kasturiratne A, Wickremasinghe AR, de Silva N, et al. The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Med 2008;5:e218.
3. Gueron M, Ilia R, Sofer S. The cardiovascular system after scorpion envenomation. A review. J Toxicol Clin Toxicol 1992;30:245-58.
4. Gueron M, Ilia R, Sofer S. Scorpion venom cardiomyopathy. Am Heart J 1993;125:1816-18.
5. Abroug F, Ayari M, Nouira S, et al. Assessment of left ventricular function in severe scorpion envenomation: combined hemodynamic and echo-Doppler study. Intensive Care Med 1995;21:629-35.
6. Bahloul M, Kallel H, Rekik N, et al. [Cardiovascular dysfunction following severe scorpion envenomation. Mechanisms and physiopathology]. Presse Med 2005;34:115-20.
7. Nouira S, Abroug F, Haguiga H, et al. Right ventricular dysfunction following severe scorpion envenomation. Chest 1995;108:682-7.
8. Abroug F, Boujdaria R, Belghith M, et al. Cardiac dysfunction and pulmonary edema following scorpion envenomation. Chest 1991;100:1057-9.
9. Elatrous S, Nouira S, Besbes-Ouanes L, et al. Dobutamine in severe scorpion envenomation: effects on standard hemodynamics, right ventricular performance, and tissue oxygenation. Chest 1999;116:748-53. (Pubitemid 29428495)
10. Yildizdas D, Yilmaz HL, Erdem S. Treatment of cardiogenic pulmonary oedema by helmet-delivered non-invasive pressure support ventilation in children with scorpion sting envenomation. Ann Acad Med Singapore 2008;37:230-4.
11. Ismail M. The treatment of the scorpion envenoming syndrome: the Saudi experience with serotherapy. Toxicon 1994;32:1019-26. (Pubitemid 24263682)
12. Natu VS, Murthy RK, Deodhar KP. Efficacy of species specific anti-scorpion venom serum (AScVS) against severe, serious scorpion stings (Mesobuthus tamulus concanesis Pocock)-an experience from rural hospital in western Maharashtra. J Assoc Physicians India 2006;54:283-7. (Pubitemid 43528606)
13. Bond GR. Antivenin administration for Centruroides scorpion sting: risks and benefits. Ann Emerg Med 1992;21:788-91.
14. De Rezende NA, Dias MB, Campolina D, et al. Efficacy of antivenom therapy for neutralizing circulating venom antigens in patients stung by Tityus serrulatus scorpions. Am J Trop Med Hyg 1995;52:277-80.
15. Rezende NA, Amaral CF, Freire-Maia L. Immunotherapy for scorpion envenoming in Brazil. Toxicon 1998;36:1507-13. (Pubitemid 28511063)
16. Report of a Consulting Meeting. WHO Library Cataloguing-in-Publication Data ISBN 978924 1563482. Geneva: World Health Organization, 2007.
17. Tarasiuk A, Khvatskin S, Sofer S. Effects of antivenom serotherapy on hemodynamic pathophysiology in dogs injected with L. quinquestriatus scorpion venom. Toxicon 1998;36:963-71. (Pubitemid 28305390)
18. Abroug F, Nouira S, El Atrous S, et al. A canine study of immunotherapy in scorpion envenomation. Intensive Care Med 2003;29:2266-76. (Pubitemid 38030680)
19. Bawaskar HS, Bawaskar PH. Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial. BMJ 2010;342:c7136.
20. Natu VS. Efficacy of anti-scorpion venom serum over prazosin in the management of severe scorpion envenomation. J Postgrad Med 2010;56:275-80.
21. Boyer LV, Theodorou AA, Berg RA, et al. Antivenom for critically ill children with neurotoxicity from scorpion stings. N Engl J Med 2009;360:2090-8.
22. Abroug F, ElAtrous S, Nouira S, et al. Serotherapy in scorpion envenomation: a randomised controlled trial. Lancet 1999;354:906-9. (Pubitemid 29424021)
23. Krifi MN, Miled K, Abderrazek M, et al. Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: towards an optimization of antivenom immunotherapy in a rabbit model. Toxicon 2001;39:1317-26. (Pubitemid 32510961)
24. Ismail M, Shibl AM, Morad AM, et al. Pharmacokinetics of 125I-labelled antivenin to the venom from the scorpion Androctonus amoreuxi. Toxicon 1983;21:47-56. (Pubitemid 13130551)
25. Ismail M, Abdullah ME, Morad AM, et al. Pharmacokinetics of 125I-labelled venom from the scorpion Androctonus amoreuxi, Aud. and Sav. Toxicon 1980;18:301-8. (Pubitemid 10027668)
26. Ismail M, Abd-Elsalam MA. Pharmacokinetics of 125I-labelled IgG, F(ab')2 and Fab fractions of scorpion and snake antivenins: merits and potential for therapeutic use. Toxicon 1998;36:1523-8. (Pubitemid 28511066)
27. Hammoudi-Triki D, Lefort J, Rougeot C, et al. Toxicokinetic and toxicodynamic analyses of Androctonus australis hector venom in rats: optimization of antivenom therapy. Toxicol Appl Pharmacol 2007;218:205-14. (Pubitemid 46201696)
28. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12. (Pubitemid 26120810)
29. von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007;370:1453-7.
30. Ghalim N, El-Hafny B, Sebti F, et al. Scorpion envenomation and serotherapy in Morocco. Am J Trop Med Hyg 2000;62:277-83. (Pubitemid 30257590)
31. LoVecchio F, McBride C. Scorpion envenomations in young children in central Arizona. J Toxicol Clin Toxicol 2003;41:937-40. (Pubitemid 38018483)
32. Belghith M, Boussarsar M, Haguiga H, et al. Efficacy of serotherapy in scorpion sting: a matched-pair study. J Toxicol Clin Toxicol 1999;37:51-7. (Pubitemid 29124571)
33. Bawaskar HS, Bawaskar PH. Utility of scorpion antivenin vs prazosin in the management of severe Mesobuthus tamulus (Indian red scorpion) envenoming at rural setting. J Assoc Physicians India 2007;55:14-21.
34. Sofer S, Shahak E, Gueron M. Scorpion envenomation and antivenom therapy. J Pediatr 1994;124:973-8. (Pubitemid 24184031)
35. Abroug F, Nouira S, Haguiga H, et al. High-dose hydrocortisone hemisuccinate in scorpion envenomation. Ann Emerg Med 1997;30:23-7. (Pubitemid 27283932)
36. Bouaziz M, Bahloul M, Kallel H, et al. Epidemiological, clinical characteristics and outcome of severe scorpion envenomation in South Tunisia: multivariate analysis of 951 cases. Toxicon 2008;52:918-26.
37. Nouira S, Boukef R, Nciri N, et al. A clinical score predicting the need for hospitalization in scorpion envenomation. Am J Emerg Med 2007;25:414-19. (Pubitemid 46710301)
38. Isbister GK. Antivenom efficacy or effectiveness: the Australian experience. Toxicology 2010;268:148-54.
39. Krifi MN, Savin S, Debray M, et al. Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy. Toxicon 2005;45:187-98. (Pubitemid 40051148)
40. Tarasiuk A, Menascu S, Sofer S. Antivenom serotherapy and volume resuscitation partially improve peripheral organ ischemia in dogs injected with scorpion venom. Toxicon 2003;42:73-7. (Pubitemid 37297562)
41. Santana GC, Freire AC, Ferreira AP, et al. Pharmacokinetics of Tityus serrulatus scorpion venom determined by enzyme-linked immunosorbent assay in the rat. Toxicon 1996;34:1063-6. (Pubitemid 26320018)
42. Nouira S, Elatrous S, Besbes L, et al. Neurohormonal activation in severe scorpion envenomation: correlation with hemodynamics and circulating toxin. Toxicol Appl Pharmacol 2005;208:111-16. (Pubitemid 41377126)
43. Sofer S, Gueron M, White RM, et al. Interleukin-6 release following scorpion sting in children. Toxicon 1996;34:389-92. (Pubitemid 26099728)
44. Matos IM, Souza DG, Seabra DG, et al. Effects of tachykinin NK1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats. Eur J Pharmacol 1999;376:293-300. (Pubitemid 29320156)
45. Adi-Bessalem S, Hammoudi-Triki D, Laraba-Djebari F. Pathophysiological effects of Androctonus australis hector scorpion venom: tissue damages and inflammatory response. Exp Toxicol Pathol 2008;60:373-80.