A genomewide linkage scan of cocaine dependence and major depressive episode in two populations

Neuropsychopharmacology

Volumn 36, Issue 12, 2011, Pages 2422-2430

  Yang, Bao Zhu ^a   Shizhong, Han ^a   Kranzler, Henry R ^b   Farrer, Lindsay A ^c   Gelernter, Joel ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

affected sib pair; cocaine dependence; comorbidity; depression; drug dependence; genomewide linkage scan

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE RECEPTOR N2; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; STEROID 5ALPHA REDUCTASE 1; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE E3C; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2;

ADULT; AFRICAN AMERICAN; ARTICLE; CHROMOSOME 5; CHROMOSOME 7; COCAINE DEPENDENCE; COMORBIDITY; CONTROLLED STUDY; EUROPEAN AMERICAN; FAMILY; FEMALE; GENE LOCATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HEALTH SURVEY; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PARAMETRIC TEST; PRIORITY JOURNAL; RECURRENT DISEASE; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME;

ADOLESCENT; ADULT; COCAINE-RELATED DISORDERS; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC LINKAGE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION SURVEILLANCE; YOUNG ADULT;

EID: 80054770600     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.122     Document Type: Article

References (50)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002). Merlin- rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30: 97-101.
2. Abkevich V, Camp NJ, Hensel CH, Neff CD, Russell DL, Hughes DC et al (2003). Predisposition locus for major depression at chromosome 12q22-12q23.2. Am J Hum Genet 73: 1271-1281. (Pubitemid 38037421)
3. Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E et al (2006). Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci USA 103: 14602-14607. (Pubitemid 44484796)
4. Andretic R, Chaney S, Hirsh J (1999). Requirement of circadian genes for cocaine sensitization in Drosophila. Science 285: 1066-1068.
5. Camp NJ, Lowry MR, Richards RL, Plenk AM, Carter C, Hensel CH et al (2005). Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. Am J Med Genet B Neuropsychiatr Genet 135: 85-93. (Pubitemid 40577861)
6. Davis LL, Frazier E, Husain MM, Warden D, Trivedi M, Fava M et al (2006). Substance use disorder comorbidity in major depressive disorder: A confirmatory analysis of the STAR*D cohort. Am J Addict 15: 278-285. (Pubitemid 44174488)
7. Eichler EE, Flint J, Gibson G, Kong A, Leal SM, Moore JH et al (2010). Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet 11: 446-450.
8. Eser D, Romeo E, Baghai TC, di Michele F, Schüle C, Pasini A et al (2006). Neuroactive steroids as modulators of depression and anxiety. Neuroscience 138: 1041-1048.
9. Evans DL, Charney DS (2003). Mood disorders and medical illness: A major public health problem. Biol Psychiatry 54: 177-180. (Pubitemid 37267845)
10. French SW, Mayer RJ, Bardag-Gorce F, Ingelman-Sundberg M, Rouach H, Neve E (2001). The ubiquitin-proteasome 26s pathway in liver cell protein turnover: Effect of ethanol and drugs. Alcohol Clin Exp Res 25(5 Suppl ISBRA): 225S-229S.
11. Garriock HA, Kraft JB, Shyn SI, Peters EJ, Yokoyama JS, Jenkins GD et al (2010). A genomewide association study of citalopram response in major depressive disorder. Biol Psychiatry 67: 133-138.
12. Gelernter J, Kranzler HR, Panhuysen C, Weiss RD, Brady K, Poling J et al (2009). Dense genomewide linkage scan for alcohol dependence in African Americans: Significant linkage on chromosome 10. Biol Psychiatry 65: 111-115.
13. Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J et al (2006). Genomewide linkage scan for opioid dependence and related traits. Am J Hum Genet 78: 759-769.
14. Gelernter J, Panhuysen C, Weiss R, Brady K, Hesselbrock V, Rounsaville B et al (2005). Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocainerelated trait and cocaine-induced paranoia. Am J Med Genet B Neuropsychiatr Genet 5: 45-52. (Pubitemid 40917527)
15. Goldman D, Oroszi G, Ducci F (2005). The genetics of addictions: Uncovering the genes. Nat Rev Genet 6: 521-532. (Pubitemid 40910429)
16. Hasin D, Liu X, Nunes E, McCloud S, Samet S, Endicott J (2002). Effects of major depression on remission and relapse of substance dependence. Arch Gen Psychiatry 59: 375-380. (Pubitemid 34275256)
17. Holmans P, Weissman MM, Zubenko GS, Scheftner WA, Crowe RR, Depaulo Jr JR et al (2007). Genetics of recurrent early-onsetmajor depression (GenRED): Final genome scan report. Am J Psychiatry 164: 248-258.
18. Holmans P, Zubenko GS, Crowe RR, DePaulo Jr JR, Scheftner WA, Weissman MM et al (2004). Genomewide significant linkage to recurrent, early onset major depressive disorder on chromosome 15q. Am J Hum Genet 74: 1154-1167. (Pubitemid 38669314)
19. Ingraham LJ, Wender PH (1992). Risk for affective disorder and alcohol and other drug abuse in the relatives of affectively ill adoptees. J Affect Disord 26: 45-51.
20. Kong A, Cox NJ (1997). Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61: 1179-1188. (Pubitemid 27492328)
21. Kumar S, Fleming RL, Morrow AL (2004). Ethanol regulation of gamma-aminobutyric acid A receptors: Genomic and nongenomic mechanisms. Pharmacol Ther 101: 211-226. (Pubitemid 38340860)
22. Lander E, Kruglyak L (1995). Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11: 241-247.
23. Levinson DF, Evgrafov OV, Knowles JA, Potash JB, Weissman MM, Scheftner WA et al (2007). Genetics of recurrent early-onset major depression (GenRED): Significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers. Am J Psychiatry 164: 259-264.
24. Li MD, Ma JZ, Payne TJ, Lou XY, Zhang D, Dupont RT et al (2008). Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. Mol Psychiatry 13: 407-416. (Pubitemid 351399816)
25. Lynch AI, Arnett DK, Atwood LD, Devereux RB, Kitzman DW, Hopkins PN (2005). A genome scan for linkage with aortic root diameter in hypertensive African Americans and whites in the Hypertension Genetic Epidemiology Network (HyperGEN) study. Am J Hypertens 18(5 part 1): 627-632. (Pubitemid 40692430)
26. MacKenzie EM, Odontiadis J, Le Mellédo JM, Prior TI, Baker GB (2007). The relevance of neuroactive steroids in schizophrenia, depression, and anxiety disorders. Cell Mol Neurobiol 27: 541-574. (Pubitemid 47038103)
27. Maher BS, Marazita ML, Zubenko WN, Kaplan BB, Zubenko GS (2002). Genetic segregation analysis of alcohol and other substance-use disorders in families with recurrent, early-onset major depression. Am J Drug Alcohol Abuse 28: 711-731. (Pubitemid 35424556)
28. Malhotra A, Igo Jr RP, Thameem F, Kao WH, Abboud HE, Adler SG et al (2009). Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: The Family Investigation of Nephropathy and Diabetes Research Group. Diabetes Metab Res Rev 25: 740-747.
29. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ et al (2009). Finding the missing heritability of complex diseases. Nature 461: 747-753.
30. McMillan I, Robertson A (1974). The power of methods for the detection of major genes affecting quantitative characters. Heredity 32: 349-356.
31. McPeek MS, Sun L (2000). Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 66: 1076-1094. (Pubitemid 30470506)
32. Mendlewicz J (2009). Disruption of the circadian timing systems: Molecular mechanisms in mood disorders. CNS Drugs 23(Suppl 2): 15-26.
33. Ng MY, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T et al (2009). Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry 14: 774-785.
34. Nishimura T, Kubosaki A, Ito Y, Notkins AL (2009). Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: Changes in behavior, learning and lifespan. Neuroscience 159: 427-437.
35. Nunes EV, Levin FR (2004). Treatment of depression in patients with alcohol or other drug dependence: A meta-analysis. JAMA 291: 1887-1896. (Pubitemid 38509503)
36. Nurnberger Jr JI, Foroud T, Flury L, Su J, Meyer ET, Hu K et al (2001). Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am J Psychiatry 158: 718-724. (Pubitemid 32429838)
37. O'Connell JR, Weeks DE (1998). PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63: 259-266. (Pubitemid 30428342)
38. Panhuysen CI, Kranzler HR, Yu Y, Weiss RD, Brady K, Poling J et al (2010). Confirmation and generalization of an alcoholdependence locus on chromosome 10q. Neuropsychopharmacology 35: 1325-1332.
39. Perreau-Lenz S, Zghoul T, Spanagel R (2007). Clock genes running amok. Clock genes and their role in drug addiction and depression. EMBO Rep 8 Spec. No: S20-S23. (Pubitemid 47335492)
40. Pierucci-Lagha A, Gelernter J, Feinn R, Cubells JF, Pearson D, Pollastri A et al (2005). Diagnostic reliability of the Semistructured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug Alcohol Depend 80: 303-312. (Pubitemid 41660851)
41. Prescott CA, Aggen SH, Kendler KS (2000). Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins. Arch Gen Psychiatry 57: 803-811. (Pubitemid 30650117)
42. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al (2007). PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575. (Pubitemid 47330214)
43. Reddy DS (2003). Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions? Trends Pharmacol Sci 24: 103-106. (Pubitemid 36293771)
44. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL (1990). Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. Jama 264: 2511-2518.
45. Riolo SA, Nguyen TA, Greden JF, King CA (2005). Prevalence of depression by race/ethnicity: Findings from the National Health and Nutrition Examination Survey III. Am J Public Health 95: 998-1000. (Pubitemid 40740711)
46. SAMSHA (2009). Results from the 2008 National Survey on Drug Use and Health: National Findings Office of Applied Studies NSDUH Series H-36. SAMSHA: Rockville, MD.
47. Self DW, Genova LM, Hope BT, Barnhart WJ, Spencer JJ, Nestler EJ (1998). Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J Neurosci 18: 1848-1859. (Pubitemid 28103092)
48. Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C et al (2006). Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am J Hum Genet 78: 315-333. (Pubitemid 43157570)
49. Tanchuck MA, Long SL, Ford MM, Hashimoto J, Crabbe JC, Roselli CE et al (2009). Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression. Alcohol Clin Exp Res 33: 2077-2087.
50. Uhl GR, Grow RW (2004). The burden of complex genetics in brain disorders. Arch Gen Psychiatry 61: 223-229. (Pubitemid 38295823)