메뉴 건너뛰기




Volumn 111, Issue 9, 2011, Pages 16-22

Acetyl-L-carnitine (carnicetine) in the treatment of early stages of Alzheimer's disease and vascular dementia

Author keywords

Acetyl L carnitine (carnicetine); Alzheimer's disease; Initial stage of disease; Mild cognitive impairment; Vascular dementia

Indexed keywords

CARNICETINE; LEVACECARNINE; UNCLASSIFIED DRUG;

EID: 80054756696     PISSN: 19977298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (25)
  • 1
    • 80054729686 scopus 로고    scopus 로고
    • Russian Source
    • Russian Source
  • 2
    • 0024363927 scopus 로고
    • Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment
    • Amenta F., Ferrante F., Lucreziotti R. et al. Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment. Arch Gerontol Geriatr 1989; 9: 147-153.
    • (1989) Arch Gerontol Geriatr , vol.9 , pp. 147-153
    • Amenta, F.1    Ferrante, F.2    Lucreziotti, R.3
  • 3
    • 0023759547 scopus 로고
    • Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-L-carnitine
    • Angelucci L., Ramacci M.T., Taglialatela G. et al. Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine. J Neurosci Res 1988; 20: 491-496.
    • (1988) J NeuroSci Res , vol.20 , pp. 491-496
    • Angelucci, L.1    Ramacci, M.T.2    Taglialatela, G.3
  • 4
    • 47149086766 scopus 로고    scopus 로고
    • Acetyl-l-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism
    • Bagetta V., Barone I., Ghiglieri V. Acetyl-l-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism. Neuropharmacology 2008; 55: 2: 223-229.
    • (2008) Neuropharmacology , vol.55 , Issue.2 , pp. 223-229
    • Bagetta, V.1    Barone, I.2    Ghiglieri, V.3
  • 5
    • 0038681645 scopus 로고    scopus 로고
    • Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors
    • Bianchetti A., Rozzini R., Trabucchi M. Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors. Curr Med Res Opin 2003; 19: 4: 350-353.
    • (2003) Curr Med Res Opin , vol.19 , Issue.4 , pp. 350-353
    • Bianchetti, A.1    Rozzini, R.2    Trabucchi, M.3
  • 6
    • 0021024932 scopus 로고
    • Carnitine-metabolism and functions
    • Bremer J. Carnitine-metabolism and functions. Physiol Rev 1983; 63: 1420-1480.
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 7
    • 0031927848 scopus 로고    scopus 로고
    • Acetyl-L-carnitine slows decline in younger patients with Alzheimer's disease: A reanalysis of a double-blind, placebo-controlled study using the trilinear approach
    • Brooks J.O. 3rd, Yesavage J.A., Carta A., Bravi D. Acetyl-L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychoger 1998; 10: 193-203.
    • (1998) Int Psychoger , vol.10 , pp. 193-203
    • Brooks III, J.O.1    Yesavage, J.A.2    Carta, A.3    Bravi, D.4
  • 8
    • 0032875579 scopus 로고    scopus 로고
    • Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion
    • Calvani M., Arrigoni-Martelli E. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int J Tissue React 1999; 21: 1-6.
    • (1999) Int J Tissue React , vol.21 , pp. 1-6
    • Calvani, M.1    Arrigoni-Martelli, E.2
  • 9
    • 0028307043 scopus 로고
    • Age-dependent loss of NM-DA receptors in hippocampus, striatum, and frontal cortex of the rat: Prevention by acetyl-L-carnitine
    • Castorina M., Ambrosini A.M., Pacific L. et al. Age-dependent loss of NM-DA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine. Neurochem Res 1994; 19: 795-798.
    • (1994) Neurochem Res , vol.19 , pp. 795-798
    • Castorina, M.1    Ambrosini, A.M.2    Pacific, L.3
  • 10
    • 53449093489 scopus 로고    scopus 로고
    • Modulatory effect of acetyl-l-carnitine on amyloid precursor protein metabolism in hippocampal neurons
    • Epis R., Marcello E., Gardoni F. et al. Modulatory effect of acetyl-l-carnitine on amyloid precursor protein metabolism in hippocampal neurons. Eur J Pharmacol 2008; 597: Issues 1-3: 51-56.
    • (2008) Eur J Pharmacol , vol.597 , Issue.1-3 , pp. 51-56
    • Epis, R.1    Marcello, E.2    Gardoni, F.3
  • 12
    • 0026767234 scopus 로고
    • Acetyl-L-carnitine releases dopamine in rat corpus striatum: An in vivo microdialysis study
    • Harsing L.G. Jr., Sershen H., Toth E. et al. Acetyl-L-carnitine releases dopamine in rat corpus striatum: an in vivo microdialysis study. Eur J Pharmacol 1992; 218: 117-121.
    • (1992) Eur J PharmaCol , vol.218 , pp. 117-121
    • Harsing Jr., L.G.1    Sershen, H.2    Toth, E.3
  • 13
    • 0024971871 scopus 로고
    • Acetyl-Lcarnitine enhances acetyl-choline release in the striatum and hippocampus of awake freely moving rats
    • Imperato A., Ramacci M.T., Angelucci L. Acetyl-Lcarnitine enhances acetyl-choline release in the striatum and hippocampus of awake freely moving rats. Neurosci Lett 1989; 107: 251-255.
    • (1989) Neurosci Lett , vol.107 , pp. 251-255
    • Imperato, A.1    Ramacci, M.T.2    Angelucci, L.3
  • 15
    • 0037347231 scopus 로고    scopus 로고
    • Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
    • Montgomery S.A., Thal L.J., Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003; 18: 61-71.
    • (2003) Int Clin Psychopharmacol , vol.18 , pp. 61-71
    • Montgomery, S.A.1    Thal, L.J.2    Amrein, R.3
  • 16
    • 0027997694 scopus 로고
    • Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: In vitro and in vivo studies
    • Pascale A., Milano S., Corsico N. et al. Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies. Eur J Pharmacol 1994; 65: 1-7.
    • (1994) Eur J PharMacol , vol.65 , pp. 1-7
    • Pascale, A.1    Milano, S.2    Corsico, N.3
  • 17
    • 0028891690 scopus 로고
    • Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease
    • Pettegrew J.W., Klunk W.E., Panchalingam K. et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging 1995; 16: 1-4.
    • (1995) Neurobiol Aging , vol.16 , pp. 1-4
    • Pettegrew, J.W.1    Klunk, W.E.2    Panchalingam, K.3
  • 18
    • 0033653231 scopus 로고    scopus 로고
    • Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: Relevance for its mode of action in Alzheimer's disease and geriatric depression
    • Pettegrew J.W., Levine J., McClure R.J. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000; 5: 616-632.
    • (2000) Molecular Psychiatry , vol.5 , pp. 616-632
    • Pettegrew, J.W.1    Levine, J.2    McClure, R.J.3
  • 19
    • 0028009683 scopus 로고
    • Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection
    • Piovesan P., Pacifici L., Taglialatela G. et al. Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection. Brain Res 1994; 633: 77-82.
    • (1994) Brain Res , vol.633 , pp. 77-82
    • Piovesan, P.1    Pacifici, L.2    Taglialatela, G.3
  • 20
    • 0026460074 scopus 로고
    • Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease
    • Sano M., Bell K., Cote L. et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Arch Neurol 1992; 49: 1137-1141.
    • (1992) Arch Neurol , vol.49 , pp. 1137-1141
    • Sano, M.1    Bell, K.2    Cote, L.3
  • 21
    • 0030248383 scopus 로고    scopus 로고
    • Spatial memory and NGF levels in aged rats: Natural variability and effects of acetyl-L-carnitine treatment
    • Taglialatela G., Caprioli A., Giuliani A. et al. Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-L-carnitine treatment. Exp Gerontol 1996; 31: 577-587.
    • (1996) Exp Gerontol , vol.31 , pp. 577-587
    • Taglialatela, G.1    Caprioli, A.2    Giuliani, A.3
  • 22
    • 0021911491 scopus 로고
    • Stereospecific effects of acetylcarnitine on the spontaneous activity of brainstem neurones and their responses to acetylcholine and serotonin
    • Tempesta E., Janiri L., Pirrongelli C. Stereospecific effects of acetylcarnitine on the spontaneous activity of brainstem neurones and their responses to acetylcholine and serotonin. Neuropharmacology 1985; 24: 43-50.
    • (1985) Neuropharmacology , vol.24 , pp. 43-50
    • Tempesta, E.1    Janiri, L.2    Pirrongelli, C.3
  • 23
    • 9544240348 scopus 로고    scopus 로고
    • A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease
    • Thal L.J., Carta A., Clarke W.R. et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Neurology 1996; 47: 705-711.
    • (1996) Neurology , vol.47 , pp. 705-711
    • Thal, L.J.1    Carta, A.2    Clarke, W.R.3
  • 24
    • 0027414925 scopus 로고
    • Effect of acetyl-L-carnitine on extracellular amino acid levels in vivo in rat brain regions
    • Toth E., Harsing L.G., Sershen H. et al. Effect of acetyl-L-carnitine on extracellular amino acid levels in vivo in rat brain regions. Neurochem Res 1993; 18: 573-578.
    • (1993) Neurochem Res , vol.18 , pp. 573-578
    • Toth, E.1    Harsing, L.G.2    Sershen, H.3
  • 25
    • 0025284835 scopus 로고
    • Acetyl-L-carnitine as a precursor of acetylcholine
    • White H.L., Scates P.W. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res 1990; 15: 597-601.
    • (1990) Neurochem Res , vol.15 , pp. 597-601
    • White, H.L.1    Scates, P.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.