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Volumn 187, Issue 8, 2011, Pages 4109-4118

Chronic chemoimmunotherapy achieves cure of spontaneous murine mammary tumors via persistent blockade of posttherapy counter-regulation

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 12; TRANSCRIPTION FACTOR FOXP3;

EID: 80054743183     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101136     Document Type: Article
Times cited : (8)

References (37)
  • 1
    • 33750802413 scopus 로고    scopus 로고
    • + T effectors
    • Kilinc, M. O., K. S. Aulakh, R. E. Nair, S. A. Jones, P. Alard, M. M. Kosiewicz, and N. K. Egilmez. 2006. Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors. J. Immunol. 177: 6962-6973. (Pubitemid 44715062)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6962-6973
    • Kilinc, M.O.1    Aulakh, K.S.2    Nair, R.E.3    Jones, S.A.4    Alard, P.5    Kosiewicz, M.M.6    Egilmez, N.K.7
  • 2
    • 33744900085 scopus 로고    scopus 로고
    • + T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors
    • Nair, R. E., M. O. Kilinc, S. A. Jones, and N. K. Egilmez. 2006. Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors. J. Immunol. 176: 7325-7334. (Pubitemid 43849033)
    • (2006) Journal of Immunology , vol.176 , Issue.12 , pp. 7325-7334
    • Nair, R.E.1    Kilinc, M.O.2    Jones, S.A.3    Egilmez, N.K.4
  • 3
    • 75149132747 scopus 로고    scopus 로고
    • Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity
    • Gu, T., R. B. Rowswell-Turner, M. O. Kilinc, and N. K. Egilmez. 2010. Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity. Cancer Res. 70: 129-138.
    • (2010) Cancer Res. , vol.70 , pp. 129-138
    • Gu, T.1    Rowswell-Turner, R.B.2    Kilinc, M.O.3    Egilmez, N.K.4
  • 4
    • 45149111788 scopus 로고    scopus 로고
    • Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy
    • Peggs, K. S., S. A. Quezada, and J. P. Allison. 2008. Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy. Immunol. Rev. 224: 141-165.
    • (2008) Immunol. Rev. , vol.224 , pp. 141-165
    • Peggs, K.S.1    Quezada, S.A.2    Allison, J.P.3
  • 5
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran, M. A., W. Montalvo, H. Yagita, and J. P. Allison. 2010. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl. Acad. Sci. USA 107: 4275-4280.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 6
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz, S. Z., and A. Rudensky. 2009. Control of regulatory T cell lineage commitment and maintenance. Immunity 30: 616-625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 7
    • 30444443314 scopus 로고    scopus 로고
    • Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines
    • DOI 10.1182/blood-2005-07-2737
    • Zhou, G., C. G. Drake, and H. I. Levitsky. 2006. Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood 107: 628-636. (Pubitemid 43076387)
    • (2006) Blood , vol.107 , Issue.2 , pp. 628-636
    • Zhou, G.1    Drake, C.G.2    Levitsky, H.I.3
  • 8
    • 33846913897 scopus 로고    scopus 로고
    • Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance
    • Zhou, G., and H. I. Levitsky. 2007. Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance. J. Immunol. 178: 2155-2162. (Pubitemid 46233413)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2155-2162
    • Zhou, G.1    Levitsky, H.I.2
  • 9
    • 24944478531 scopus 로고    scopus 로고
    • Leveraging the activity of tumor vaccines with cytotoxic chemotherapy
    • DOI 10.1158/0008-5472.CAN-05-1797
    • Emens, L. A., and E. M. Jaffee. 2005. Leveraging the activity of tumor vaccines with cytotoxic chemotherapy. Cancer Res. 65: 8059-8064. (Pubitemid 41330564)
    • (2005) Cancer Research , vol.65 , Issue.18 , pp. 8059-8064
    • Emens, L.A.1    Jaffee, E.M.2
  • 11
    • 0014649984 scopus 로고
    • Modification of tumor regression by immunologic means
    • Mihich, E. 1969. Modification of tumor regression by immunologic means. Cancer Res. 29: 2345-2350.
    • (1969) Cancer Res. , vol.29 , pp. 2345-2350
    • Mihich, E.1
  • 15
    • 33751209215 scopus 로고    scopus 로고
    • Combined chemoimmunotherapy of solid tumours: Improving vaccines?
    • DOI 10.1016/j.addr.2006.04.002, PII S0169409X06001426
    • Nowak, A. K., R. A. Lake, and B. W. S. Robinson. 2006. Combined chemoimmunotherapy of solid tumours: improving vaccines? Adv. Drug Deliv. Rev. 58: 975-990. (Pubitemid 44780907)
    • (2006) Advanced Drug Delivery Reviews , vol.58 , Issue.8 , pp. 975-990
    • Nowak, A.K.1    Lake, R.A.2    Robinson, B.W.S.3
  • 16
    • 70350108862 scopus 로고    scopus 로고
    • Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination
    • Radojcic, V., K. B. Bezak, M. Skarica, M. A. Pletneva, K. Yoshimura, R. D. Schulick, and L. Luznik. 2010. Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination. Cancer Immunol. Immunother. 59: 137-148.
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 137-148
    • Radojcic, V.1    Bezak, K.B.2    Skarica, M.3    Pletneva, M.A.4    Yoshimura, K.5    Schulick, R.D.6    Luznik, L.7
  • 17
    • 79251535018 scopus 로고    scopus 로고
    • Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells
    • Medina-Echeverz, J., J. Fioravanti, M. Zabala, N. Ardaiz, J. Prieto, and P. Berraondo. 2011. Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells. J. Immunol. 186: 807-815.
    • (2011) J. Immunol. , vol.186 , pp. 807-815
    • Medina-Echeverz, J.1    Fioravanti, J.2    Zabala, M.3    Ardaiz, N.4    Prieto, J.5    Berraondo, P.6
  • 18
    • 0037115541 scopus 로고    scopus 로고
    • Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: Coinduction of innate and adaptive antitumor immunity and cure of disseminated disease
    • Hill, H. C., T. F. Conway, Jr., M. S. Sabel, Y. S. Jong, E. Mathiowitz, R. B. Bankert, and N. K. Egilmez. 2002. Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated disease. Cancer Res. 62: 7254-7263. (Pubitemid 36025247)
    • (2002) Cancer Research , vol.62 , Issue.24 , pp. 7254-7263
    • Hill, H.C.1    Conway Jr., T.F.2    Sabel, M.S.3    Jong, Y.S.4    Mathiowitz, E.5    Bankert, R.B.6    Egilmez, N.K.7
  • 19
    • 42649131089 scopus 로고    scopus 로고
    • Transient activation of tumor-associated T-effector/memory cells promotes tumor eradication via NK-cell recruitment: Minimal role for long-term T-cell immunity in cure of metastatic disease
    • Gu, T., M. O. Kilinc, and N. K. Egilmez. 2008. Transient activation of tumor-associated T-effector/memory cells promotes tumor eradication via NK-cell recruitment: minimal role for long-term T-cell immunity in cure of metastatic disease. Cancer Immunol. Immunother. 57: 997-1005.
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 997-1005
    • Gu, T.1    Kilinc, M.O.2    Egilmez, N.K.3
  • 20
    • 0035710746 scopus 로고    scopus 로고
    • -DeltaDeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 21
    • 12944254575 scopus 로고    scopus 로고
    • DNA vaccination with full-length or truncated Neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    • Amici, A., A. Smorlesi, G. Noce, G. Santoni, P. Cappelletti, L. Capparuccia, R. Coppari, R. Lucciarini, C. Petrelli, and M. Provinciali. 2000. DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Gene Ther. 7: 703-706. (Pubitemid 30255775)
    • (2000) Gene Therapy , vol.7 , Issue.8 , pp. 703-706
    • Amici, A.1    Smorlesi, A.2    Noce, G.3    Santoni, G.4    Cappelletti, P.5    Capparuccia, L.6    Coppari, R.7    Lucciarini, R.8    Petrelli, C.9    Provinciali, M.10
  • 22
    • 0141992909 scopus 로고    scopus 로고
    • HSP110-HER2/neu chaperone complex vaccine induces protective immunity against spontaneous mammary tumors in HER-2/neu transgenic mice
    • Manjili, M. H., X. Y. Wang, X. Chen, T. Martin, E. A. Repasky, R. Henderson, and J. R. Subjeck. 2003. HSP110-HER2/neu chaperone complex vaccine induces protective immunity against spontaneous mammary tumors in HER-2/neu transgenic mice. J. Immunol. 171: 4054-4061. (Pubitemid 37238680)
    • (2003) Journal of Immunology , vol.171 , Issue.8 , pp. 4054-4061
    • Manjili, M.H.1    Wang, X.-Y.2    Chen, X.3    Martin, T.4    Repasky, E.A.5    Henderson, R.6    Subjeck, J.R.7
  • 23
    • 1642316449 scopus 로고    scopus 로고
    • + T cell repertoire against Her-2/neu antigens in neu transgenic mice is low avidity with antitumor activity
    • DOI 10.1002/eji.200324427
    • Lustgarten, J., A. L. Dominguez, and C. Cuadros. 2004. The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity. Eur. J. Immunol. 34: 752-761. (Pubitemid 39255923)
    • (2004) European Journal of Immunology , vol.34 , Issue.3 , pp. 752-761
    • Lustgarten, J.1    Dominguez, A.L.2    Cuadros, C.3
  • 24
    • 34848871340 scopus 로고    scopus 로고
    • Delayed tumor onset and reduced tumor growth progression after immunization with a Her-2/neu multi-peptide vaccine and IL-12 in c-neu transgenic mice
    • DOI 10.1007/s10549-006-9469-4
    • Wagner, S., J. Jasinska, H. Breiteneder, M. Kundi, H. Pehamberger, O. Scheiner, C. C. Zielinski, and U. Wiedermann. 2007. Delayed tumor onset and reduced tumor growth progression after immunization with a Her-2/neu multi-peptide vaccine and IL-12 in c-neu transgenic mice. Breast Cancer Res. Treat. 106: 29-38. (Pubitemid 47498086)
    • (2007) Breast Cancer Research and Treatment , vol.106 , Issue.1 , pp. 29-38
    • Wagner, S.1    Jasinska, J.2    Breiteneder, H.3    Kundi, M.4    Pehamberger, H.5    Scheiner, O.6    Zielinski, C.C.7    Wiedermann, U.8
  • 25
    • 33644831689 scopus 로고    scopus 로고
    • IL-12 + GM-CSF microsphere therapy induces eradication of advanced spontaneous tumors in her-2/neu transgenic mice but fails to achieve long-term cure due to the inability to maintain effector T-cell activity
    • Nair, R. E., Y. S. Jong, S. A. Jones, A. Sharma, E. Mathiowitz, and N. K. Egilmez. 2006. IL-12 + GM-CSF microsphere therapy induces eradication of advanced spontaneous tumors in her-2/neu transgenic mice but fails to achieve long-term cure due to the inability to maintain effector T-cell activity. J. Immunother. 29: 10-20.
    • (2006) J. Immunother. , vol.29 , pp. 10-20
    • Nair, R.E.1    Jong, Y.S.2    Jones, S.A.3    Sharma, A.4    Mathiowitz, E.5    Egilmez, N.K.6
  • 26
    • 0030995686 scopus 로고    scopus 로고
    • Treatment with neutralizing antibodies specific for IL-1beta prevents cyclophosphamide-induced diabetes in nonobese diabetic mice
    • Cailleau, C., A. Diu-Hercend, E. Ruuth, R. Westwood, and C. Carnaud. 1997. Treatment with neutralizing antibodies specific for IL-1beta prevents cyclophosphamide-induced diabetes in nonobese diabetic mice. Diabetes 46: 937-940. (Pubitemid 27220991)
    • (1997) Diabetes , vol.46 , Issue.6 , pp. 937-940
    • Cailleau, C.1    Diu-Hercend, A.2    Ruuth, E.3    Westwood, R.4    Carnaud, C.5
  • 27
    • 0036015652 scopus 로고    scopus 로고
    • IL-1beta expression in islet cells of the NOD mouse and its spatial relationship to beta cells and inducible nitric oxide synthase
    • Reddy, S., and M. Young. 2002. IL-1beta expression in islet cells of the NOD mouse and its spatial relationship to beta cells and inducible nitric oxide synthase. Ann. N. Y. Acad. Sci. 958: 190-193. (Pubitemid 34592225)
    • (2002) Annals of the New York Academy of Sciences , vol.958 , pp. 190-193
    • Reddy, S.1    Young, M.2
  • 28
    • 41149178490 scopus 로고    scopus 로고
    • Comparative methodologies of regulatory T cell depletion in a murine melanoma model
    • Matsushita, N., S. A. Pilon-Thomas, L. M. Martin, and A. I. Riker. 2008. Comparative methodologies of regulatory T cell depletion in a murine melanoma model. J. Immunol. Methods 333: 167-179.
    • (2008) J. Immunol. Methods , vol.333 , pp. 167-179
    • Matsushita, N.1    Pilon-Thomas, S.A.2    Martin, L.M.3    Riker, A.I.4
  • 30
    • 0035328683 scopus 로고    scopus 로고
    • Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice
    • Machiels, J.-P. H., R. T. Reilly, L. A. Emens, A. M. Ercolini, R. Y. Lei, D. Weintraub, F. I. Okoye, and E. M. Jaffee. 2001. Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice. Cancer Res. 61: 3689-3697. (Pubitemid 32694981)
    • (2001) Cancer Research , vol.61 , Issue.9 , pp. 3689-3697
    • Machiels, J.-P.H.1    Todd, R.R.2    Emens, L.A.3    Ercolini, A.M.4    Lei, R.Y.5    Weintraub, D.6    Okoye, F.I.7    Jaffee, E.M.8
  • 32
    • 0043136619 scopus 로고    scopus 로고
    • + T cell effector function and tumor-free survival in Her-2/neu-transgenic mice
    • Wolpoe, M. E., E. R. Lutz, A. M. Ercolini, S. Murata, S. E. Ivie, E. S. Garrett, L. A. Emens, E. M. Jaffee, and R. T. Reilly. 2003. HER-2/neu-specific monoclonal antibodies collaborate with HER-2/neu-targeted granulocyte macrophage colony-stimulating factor secreting whole cell vaccination to augment CD8+ T cell effector function and tumor-free survival in Her-2/neu-transgenic mice. J. Immunol. 171: 2161-2169. (Pubitemid 36966500)
    • (2003) Journal of Immunology , vol.171 , Issue.4 , pp. 2161-2169
    • Wolpoe, M.E.1    Lutz, E.R.2    Ercolini, A.M.3    Murata, S.4    Ivie, S.E.5    Garrett, E.S.6    Emens, L.A.7    Jaffee, E.M.8    Reilly, R.T.9
  • 33
    • 64249096161 scopus 로고    scopus 로고
    • Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity
    • Kilinc, M. O., T. Gu, J. L. Harden, L. P. Virtuoso, and N. K. Egilmez. 2009. Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity. J. Immunol. 182: 4217-4225.
    • (2009) J. Immunol. , vol.182 , pp. 4217-4225
    • Kilinc, M.O.1    Gu, T.2    Harden, J.L.3    Virtuoso, L.P.4    Egilmez, N.K.5
  • 34
    • 0031870766 scopus 로고    scopus 로고
    • Down regulation of major histocompatibility complex class I expression in mammary carcinoma of HER-2/neu transgenic mice
    • DOI 10.1002/(SICI)1097-0215(19980911)77:6<937::AID-IJC24>3.0.CO;2-X
    • Lollini, P.-L., G. Nicoletti, L. Landuzzi, C. De Giovanni, I. Rossi, E. Di Carlo, P. Musiani, W. J. Muller, and P. Nanni. 1998. Down regulation of major histocompatibility complex class I expression in mammary carcinoma of HER-2/neu transgenic mice. Int. J. Cancer 77: 937-941. (Pubitemid 28378147)
    • (1998) International Journal of Cancer , vol.77 , Issue.6 , pp. 937-941
    • Lollini, P.-L.1    Nicoletti, G.2    Landuzzi, L.3    De Giovanni, C.4    Rossi, I.5    Di, C.E.6    Musiani, P.7    Muller, W.J.8    Nanni, P.9
  • 36
    • 0242300038 scopus 로고    scopus 로고
    • Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation
    • DOI 10.1016/j.virol.2003.07.001
    • van der Most, R. G., K. Murali-Krishna, J. G. Lanier, E. J. Wherry, M. T. Puglielli, J. N. Blattman, A. Sette, and R. Ahmed. 2003. Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology 315: 93-102. (Pubitemid 37340053)
    • (2003) Virology , vol.315 , Issue.1 , pp. 93-102
    • Van Der, M.R.G.1    Murali-Krishna, K.2    Lanier, J.G.3    Wherry, E.J.4    Puglielli, M.T.5    Blattman, J.N.6    Sette, A.7    Ahmed, R.8


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