Taylor dispersion analysis compared to dynamic light scattering for the size analysis of therapeutic peptides and proteins and their aggregates

Pharmaceutical Research

Volumn 28, Issue 9, 2011, Pages 2302-2310

  Hawe, Andrea ^a   Hulse, Wendy L ^b   Jiskoot, Wim ^a   Forbes, Robert T ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Dynamic light scattering; Hydrodynamic size; Protein aggregation; Protein characterization; Taylor dispersion analysis

Indexed keywords

ADALIMUMAB; BOVINE SERUM ALBUMIN; ETANERCEPT; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; OXYTOCIN; PLACEBO; RITUXIMAB;

ANALYTIC METHOD; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISPERSION; DRUG FORMULATION; HYDRODYNAMICS; LIGHT SCATTERING; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; SENSITIVITY ANALYSIS; TAYLOR DISPERSION ANALYSIS; TEMPERATURE SENSITIVITY; THEORETICAL STUDY;

BIOPHARMACEUTICS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; DRUG STABILITY; EXCIPIENTS; HOT TEMPERATURE; HYDRODYNAMICS; LIGHT; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEINS; SCATTERING, RADIATION;

EID: 80054742841     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0460-3     Document Type: Article

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