Using pH abnormalities in diseased skin to trigger and target topical therapy

Pharmaceutical Research

Volumn 28, Issue 10, 2011, Pages 2589-2598

  Rizi, Khalida ^a   Green, Rebecca J ^a   Donaldson, Michael X ^b   Williams, Adrian C ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b Eurasia Headquarters   (United Kingdom)

Author keywords

Carbopol; Eudragit L100; hydrocortisone; hydroxypropyl methyl cellulose; pH responsive microparticles

Indexed keywords

CARBOMER; EUDRAGIT; HYDROCORTISONE; HYDROXYPROPYLMETHYLCELLULOSE;

ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG PENETRATION; DRUG STABILITY; EXPERIMENTAL MODEL; GEL; IN VITRO STUDY; MICROCAPSULE; MICROENCAPSULATION; NONHUMAN; PH; PIG SKIN; POROSITY; PRIORITY JOURNAL; SKIN; SKIN PH; SPRAY DRYING; SURFACE PROPERTY; SWINE;

ADMINISTRATION, TOPICAL; ANIMALS; CAPSULES; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; GELS; HYDROCORTISONE; HYDROGEN-ION CONCENTRATION; PARTICLE SIZE; PERMEABILITY; POLYMERS; POLYVINYLS; SKIN; SKIN ABSORPTION; SKIN DISEASES; SOLUBILITY; SWINE;

EID: 80054738031     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0488-4     Document Type: Article

References (42)

1. UR Hengge T Ruzicka RA Schwartz MJ Cork 2006 Adverse effects of topical glucocorticosteroids J Am Acad Dermatol 54 1 1 16384751 10.1016/j.jaad.2005.01. 010 (Pubitemid 41832453)
2. EM Ohman S Rogers FO Meenan TJ McKenna 1987 Adrenal suppression following low-dose topical clobetasol propionate J R Soc Med 80 7 422 424 3656312 1:STN:280:DyaL1c%2FhtFSgsg%3D%3D (Pubitemid 17118202)
3. H Schäcke A Schottelius W-D Döcke P Strehlke S Jaroch N Schmees, et al. 2004 Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects PNAS 101 1 227 232 14694204 10.1073/pnas.0300372101 (Pubitemid 38084232)
4. JW Fluhr PM Elias 2002 Stratum corneum pH: formation and function of the "acid mantle" Exogenous Dermatol 1 163 175 10.1159/000066140 1:CAS:528:DC%2BD38XosVCnu7s%3D (Pubitemid 36717561)
5. B Eberlein-König T Schafer J Huss-Marp U Darsow M Mohrenschlager O Herbert, et al. 2000 Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children Acta Derm Venereol 80 188 191 10954209 10.1080/000155500750042943
6. MH Schmid-Wendtner HC Korting 2006 The pH of the skin surface and its impact on the barrier function Skin Pharmacol Physiol 19 6 296 302 16864974 10.1159/000094670 (Pubitemid 44808083)
7. A Sparavigna M Setaro V Gualandri 1999 Cutaneous pH in children affected by atopic dermatitis and in healthy children: a multicenter study Skin Res Technol 5 4 221 227 10.1111/j.1600-0846.1999.tb00134.x (Pubitemid 29504971)
8. K Chikakane H Takahashi 1995 Measurement of skin pH and its significance in cutaneous diseases Clin Dermatol 13 4 299 306 8665438 10.1016/0738-081X(95) 00076-R 1:STN:280:DyaK283jsFyjsA%3D%3D (Pubitemid 26014442)
9. D Anderson 1951 The acid-base balance of the skin Br J Dermatol 63 283 296 14869598 10.1111/j.1365-2133.1951.tb13728.x 1:CAS:528:DyaG3sXjsFegtw%3D%3D
10. Rizi K, Green RJ, Khutoryanskaya O, Donaldson M, Williams AC. Mechanisms of burst release from pH-responsive polymeric microparticles. J Pharm Pharmacol. 2010:In Press.
11. K Rizi RJ Green M Donaldson AC Williams 2010 Production of pH-responsive microparticles by spray drying: Investigation of experimental parameter effects on morphological and release properties J Pharm Sci 100 2 566 579 20799364 10.1002/jps.22291
12. RA Kendall MA Alhnan S Nilkumhang S Murdan AW Basit 2009 Fabrication and in vivo evaluation of highly pH-responsive acrylic microparticles for targeted gastrointestinal delivery Eur J Pharm Sci 37 3-4 284 290 19491017 10.1016/j.ejps.2009.02.015 1:CAS:528:DC%2BD1MXms1Oks7o%3D
13. U Jacobi M Kaiser R Toll S Mangelsdorf H Audring N Otberg W Sterry J Lademann 2007 Porcine ear skin: an in vitro model for human skin Skin Res Tech 13 19 24 10.1111/j.1600-0846.2006.00179.x (Pubitemid 46152448)
14. F Muhammad JD Brooks JE Riviere 2004 Comparative mixture effects of JP(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems Toxicol Lett 150 351 365 15110087 10.1016/j.toxlet.2004.02.012 1:CAS:528:DC%2BD2cXjsVWrt74%3D (Pubitemid 38510587)
15. DL French KJ Himmelstein JW Mauger 1995 Physicochemical aspects of controlled release of substituted benzoic and naphthoic acids from Carbopol® gels J Control Release 37 3 281 289 10.1016/0168-3659(95)00086-0 1:CAS:528:DyaK2MXhtVSgt7jM (Pubitemid 26007538)
16. R Salama S Hoe H-K Chan D Traini PM Young 2008 Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: influence of polymer concentration on physical and in vitro characteristics Eur J Pharm Biopharm 69 2 486 495 18226880 10.1016/j.ejpb.2007.12.019 1:CAS:528:DC%2BD1cXmtVShu7c%3D
17. SK Klee M Farwick P Lersch 2009 Triggered release of sensitive active ingredients upon response to the skin's natural pH Colloid Surf Physicochem Eng Aspect 338 1-3 162 166 10.1016/j.colsurfa.2008.11.035 1:CAS:528: DC%2BD1MXitF2nsrc%3D
18. R Alvarez-Roman G Barre RH Guy H Fessi 2001 Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection Eur J Pharm Biopharm 52 191 195 11522485 10.1016/S0939-6411(01)00188-6 1:CAS:528:DC%2BD3MXmtV2ktLc%3D (Pubitemid 32755898)
19. V Jenning A Gysler M Schafer-Korting S Gohla 2000 Vitamin A loaded solid lipid nanoparticles for topical use:occlusive properties and drug targeting to the upper skin Eur J Pharm Biopharm 49 211 218 10799811 10.1016/S0939-6411(99) 00075-2 1:CAS:528:DC%2BD3cXivVGmtbo%3D (Pubitemid 30229868)
20. R Alvarez-Roman A Naik YN Kalia RH Guy H Fessi 2004 Skin penetration and distribution of polymeric nanoparticles J Control Release 99 1 53 15342180 10.1016/j.jconrel.2004.06.015 1:CAS:528:DC%2BD2cXnt1Kjtrc%3D (Pubitemid 39165733)
21. Y Zhao MB Brown SA Jones 2010 Pharmaceutical foams: are they the answer to the dilemma of topical nanoparticles? Nanomed Nanotechnol Biol Med 6 2 227 236 10.1016/j.nano.2009.08.002 1:CAS:528:DC%2BC3cXksVCgtLg%3D
22. F Knorr J Lademann A Patzelt W Sterry U Blume-Peytavi A Vogt 2008 Follicular transport route-Research progress and future perspectives Eur J Pharm Biopharm 71 2 173 180 19041720 10.1016/j.ejpb.2008.11.001
23. J Lademann H Richter A Teichmann N Otberg U Blume-Peytavi J Luengo, et al. 2007 Nanoparticles-An efficient carrier for drug delivery into the hair follicles Eur J Pharm Biopharm 66 2 159 17169540 10.1016/j.ejpb.2006.10.019 1:CAS:528:DC%2BD2sXkslChtro%3D (Pubitemid 46654773)
24. GL Flynn 1983 Comparision between in vivo techniques Acta Pharm Suec 20 54 59
25. Poulsen BJ, Flynn GL. In vitro methods to study dermal delivery and percutaneous absorption. In: Bronaugh RL, Maibach HI, editors. Percutaneous absorption: mechanism, absorption and drug delivery. New York: Marcel Dekker; 1985. p. 431-59.
26. RO Salama D Traini H-K Chan PM Young 2008 Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols Eur J Pharm Biopharm 70 1 145 152 18534832 10.1016/j.ejpb.2008.04.009 1:CAS:528:DC%2BD1cXhtVOitrjM
27. British National Formulary. 59 ed: British Medical Association & Royal Pharmaceutical Society of Great Britain; March 2010.
28. Barry BW. Dermatological formulations:percutaneous absorption. 1st ed. New York: Marcel Dekker Inc; 1993.
29. L Stankler 1974 Diseases of the skin Br Med J 1 27 29 10.1136/bmj.1.5896.27
30. Guo J-H. Carbopol polymers for pharmaceutical drug delivery applications. Drug Deliv Technol. 2003.
31. J Labanda P Marco J Llorens 2004 Rheological model to predict the thixotropic behaviour of colloidal dispersions Colloid Surf Physicochem Eng Aspect 249 1-3 123 126 10.1016/j.colsurfa.2004.08.062 1:CAS:528: DC%2BD2cXhtVSrtr3M (Pubitemid 39531602)
32. M Glavas-Dodov K Goracinova K Mladenovska E Fredro-Kumbaradzi 2002 Release profile of lidocaine HCl from topical liposomal gel formulation Int J Pharm 242 1-2 381 384 12176284 10.1016/S0378-5173(02)00221-1 1:CAS:528:DC%2BD38Xmt1ygtbo%3D
33. G Lu HW Jun 1998 Diffusion studies of methotrexate in Carbopol and Poloxamer gels Int J Pharm 160 1 1 9 10.1016/S0378-5173(97)00187-7 1:CAS:528:DyaK1cXntVCisw%3D%3D (Pubitemid 28059924)
34. S-C Shin C-W Cho K-H Yang 2004 Development of lidocaine gels for enhanced local anesthetic action Int J Pharm 287 1-2 73 78 15541914 10.1016/j.ijpharm. 2004.08.012 1:CAS:528:DC%2BD2cXps1OqtLo%3D (Pubitemid 39487245)
35. MM Dolan RL Steelman RR Tumilowicz 1960 Carbopol 934: an improved suspending agent for insoluble test compounds Toxicol Appl Pharmacol 2 3 331 337 13817279 10.1016/0041-008X(60)90061-2 1:CAS:528:DyaF3cXhtVGnurw%3D
36. RJ Meyer L Cohen 1959 The rheology of natural and synthetic hydrophilic polymer solutions as related to suspending ability J Soc Cosmet Chem 10 143 154 1:CAS:528:DyaG1MXps1Gltw%3D%3D
37. BM Berney PB Deasy 1979 Evaluation of carbopol 934 as a suspending agent for sulphaoimidine suspensions Int J Pharm 3 2-3 73 80 10.1016/0378-5173(79) 90067-X 1:CAS:528:DyaE1MXls1aqu70%3D (Pubitemid 9237753)
38. AF El-Kattan CS Asbill BB Michniak 2000 The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems Int J Pharm 198 2 179 189 10767567 10.1016/S0378-5173(00)00330- 6 1:CAS:528:DC%2BD3cXitlelurk%3D (Pubitemid 30184855)
39. Formulating hydroalcoholic gels with Carbopol polymers. Noveon Technical Data Sheet; 2009.
40. S-Y Lin C-M Liao G-H Hsiue R-C Liang 1995 Study of a theophylline- Eudragit L mixture using a combined system of microscopic Fourier-transform infrared spectroscopy and differential scanning calorimetry Thermochim Acta 254 153 166 10.1016/0040-6031(94)02114-4 1:CAS:528:DyaK2MXlsFGqtro%3D
41. H Eerikainen EI Kauppinen 2003 Preparation of polymeric nanoparticles containing corticosteroid by a novel aerosol flow reactor method Int J Pharm 263 1-2 69 12954182 10.1016/S0378-5173(03)00370-3 1:CAS:528:DC%2BD3sXmvValt7s%3D (Pubitemid 37087934)
42. DT Friesen R Shanker M Crew DT Smithey WJ Curatolo JAS Nightingale 2008 Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: an overview Mol Pharm 5 6 1003 1019 19040386 10.1021/mp8000793 1:CAS:528:DC%2BD1cXhsVSntb3F