Bidirectional regulation of human colonic smooth muscle contractility by tachykinin NK2 receptors

Journal of Pharmacological Sciences

Volumn 117, Issue 2, 2011, Pages 106-115

  Nakamura, Akihiro ^a   Tanaka, Takahiro ^a   Imanishi, Akio ^a   Kawamoto, Makiko ^a   Toyoda, Masao ^b   Mizojiri, Gaku ^b   Tsukimi, Yasuhiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b SAISEIKAI NAKATSU HOSPITAL   (Japan)

Author keywords

Human colon; Smooth muscle

Indexed keywords

NEUROKININ 2 RECEPTOR; NEUROKININ A; NEUROKININ B; NEURONAL NITRIC OXIDE SYNTHASE; SUBSTANCE P;

ADULT; AGED; ARTICLE; BINDING AFFINITY; COLON MOTILITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; MALE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION;

EID: 80054732021     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11118FP     Document Type: Article

References (30)

1. Pennefather JN, Lecci A, Candenas ML, Patak E, Pinto FM, Maggi CA. Tachykinins and tachykinin receptors: a growing family. Life Sci. 2004;74:1445-1463. (Pubitemid 38077208)
2. Cao W, Pricolo VE, Zhang L, Behar J, Biancani P, Kirber MT. Gq-linked NK(2) receptors mediate neurally induced contraction of human sigmoid circular smooth muscle. Gastroenterology. 2000;119:51-61. (Pubitemid 30452578)
3. Maggi CA. The mammalian tachykinin receptors. Gen Pharmacol. 1995;26:911-944.
4. Drapeau G, D'Orleans-Juste P, Dion S, Rhaleb NE, Rouissi NE, Regoli D. Selective agonists for substance P and neurokinin receptors. Neuropeptides. 1987;10:43-54. (Pubitemid 17130244)
5. Lecci A, Maggi CA. Peripheral tachykinin receptors as potential therapeutic targets in visceral diseases. Expert Opin Ther Targets. 2003;7:343-362. (Pubitemid 36722220)
6. McLean S, Ganong A, Seymour PA, Bryce DK, Crawford RT, Morrone J, et al. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J Pharmacol Exp Ther. 1996;277:900-908. (Pubitemid 27169002)
7. Emonds-Alt X, Vilain P, Goulaouic P, Proietto V, Van Broeck D, Advenier C, et al. A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life Sci. 1992;50:PL101-PL106.
8. Sarau HM, Griswold DE, Potts W, Foley JJ, Schmidt DB, Webb EF, et al. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther. 1997;281:1303-1311. (Pubitemid 27258390)
9. Holzer P, Holzer-Petsche U. Tachykinins in the gut. Part I. Expression, release and motor function. Pharmacol Ther. 1997;73: 173-217. (Pubitemid 27224437)
10. Giuliani S, Lecci A, Giachetti A, Maggi CA. Tachykinins and reflexly evoked atropine-resistant motility in the guinea pig colon in vivo. J Pharmacol Exp Ther. 1993;265:1224-1231. (Pubitemid 23321023)
11. Maggi CA, Catalioto RM, Criscuoli M, Cucchi P, Giuliani S, Lecci A, et al. Tachykinin receptors and intestinal motility. Can J Physiol Pharmacol. 1997;75:696-703. (Pubitemid 27458659)
12. Vilain P, Emonds-Alt X, Le Fur G, Breliere JC. Tachykinin-induced contractions of the guinea pig ileum longitudinal smooth muscle: tonic and phasic muscular activities. Can J Physiol Pharmacol. 1997;75:587-590. (Pubitemid 27458641)
13. Lecci A, Tramontana M, Giuliani S, Maggi CA. Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists. Can J Physiol Pharmacol. 1997;75: 582-586. (Pubitemid 27458640)
14. Mule F, Amato A, Serio R. Role for NK(1) and NK(2) receptors in the motor activity in mouse colon. Eur J Pharmacol. 2007; 570:196-202. (Pubitemid 47247681)
15. Parlani M, Conte B, Cirillo R, Manzini S. Characterization of tachykinin NK2 receptor on dog proximal colon. Antagonism by MEN 10,627 and SR 48,968. Eur J Pharmacol. 1996;318: 419-424. (Pubitemid 27046286)
16. Jensen CJ, Gerard NP, Schwartz TW, Gether U. The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors. Mol Pharmacol. 1994;45:294-299. (Pubitemid 24063083)
17. Meini S, Bellucci F, Catalani C, Cucchi P, Giolitti A, Sant icioli P, et al. Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)- piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) at the human tachykinin NK2 receptor. J Pharmacol Exp Ther. 2009;329: 486-495.
18. Croci T, Aureggi G, Manara L, Emonds-Alt X, Le Fur G, Maffrand JP, et al. In vitro characterization of tachykinin NK2-receptors modulating motor responses of human colonic muscle strips. Br J Pharmacol. 1998;124:1321-1327. (Pubitemid 28333959)
19. Regoli D, Boudon A, Fauchere JL. Receptors and antagonists for substance P and related peptides. Pharmacol Rev. 1994;46: 551-599.
20. Al-Saffar A, Hellstrom PM. Contractile responses to natural tachykinins and selective tachykinin analogs in normal and inflamed ileal and colonic muscle. Scand J Gastroenterol. 2001; 36:485-493. (Pubitemid 32328438)
21. Payan DG, McGillis JP, Organist ML. Binding characteristics and affinity labeling of protein constituents of the human IM9 lymphoblast receptor for substance P. J Biol Chem. 1986;261: 14321-14329. (Pubitemid 17196343)
22. Jaafari N, Hua G, Adelaide J, Jule Y, Imbert J. Expression of the tachykinin receptor mRNAs in healthy human colon. Eur J Pharmacol. 2008;599:121-125.
23. Lordal M, Theodorsson E, Hellstrom P. Tachykinins influence interdigestive rhythm and contractile strength of human small intestine. Dig Dis Sci. 1997;42:1940-1949. (Pubitemid 27433544)
24. Lordal M, Navalesi G, Theodorsson E, Maggi CA, Hellstrom P. A novel tachykinin NK2 receptor antagonist prevent motility-stimulating effects of neurokinin A in small intestine. Br J Pharmacol. 2001;134:215-223. (Pubitemid 32835485)
25. Lecci A, Capriati A, Maggi CA. Tachykinin NK2 receptor antagonists for the treatment of irritable bowel syndrome. Br J Pharmacol. 2004;141:1249-1263. (Pubitemid 38638814)
26. Lecci A, Capriati A, Altamura M, Maggi CA. Tachykinin receptors in the gut, with special reference to NK2 receptors in human. Auton Neurosci. 2006;126-127:232-249. (Pubitemid 43833351)
27. Jaafari N, Khomitch-Baud A, Christen MO, Jule Y. Distribution pattern of tachykinin NK2 receptors in human colon: involvement in the regulation of intestinal motility. J Comp Neurol. 2007;503:381-391. (Pubitemid 46982478)
28. Bartho L, Lefebvre RA. Nitric oxide-mediated contraction in enteric smooth muscle. Arch Int Pharmacodyn Ther. 1995;329: 53-56.
29. Tien X, Wallace L, Kachur J, Won-Kim S, Gaginella T. Neurokinin A increases short-circuit current across rat colonic mucosa: a role for vasoactive intestinal polypeptide. J Physiol. 1991;437: 341-350.
30. Gallego D, Gil V, Aleu J, Auli M, Clave P, Jimenez M. Purinergic and nitrergic junction potential in the human colon. Am J Physiol Gastrointest Liver Physiol. 2008;295:G522-G533.