Impact of pulmonary vascular resistances in heart transplantation for congenital heart disease

Current Cardiology Reviews

Volumn 7, Issue 2, 2011, Pages 59-66

  Gazit, Avihu Z ^a   Canter, Charles E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Congenital heart disease; Heart transplantation; Pulmonary vascular resistance

Indexed keywords

CONGENITAL HEART DISEASE; HEART FAILURE; HEART TRANSPLANTATION; HUMAN; LUNG BLOOD FLOW; LUNG BLOOD VESSEL; LUNG HEMODYNAMICS; LUNG VASCULAR RESISTANCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; SHEAR STRESS; VASCULAR ENDOTHELIUM;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; HEART DEFECTS, CONGENITAL; HEART DISEASES; HEART FAILURE; HEART TRANSPLANTATION; HEART VENTRICLES; HEMORHEOLOGY; HUMANS; HYPERTENSION, PULMONARY; INFANT; PULMONARY CIRCULATION; PULMONARY HEART DISEASE; VASCULAR RESISTANCE; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 80054727906     PISSN: 1573403X     EISSN: 18756557     Source Type: Journal    
DOI: 10.2174/157340311797484213     Document Type: Review

References (93)

1. Kirk R, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: thirteenth official pediatric heart transplantation report-2010. J Heart Lung Transplant 2010; 29(10):1119-28.
2. Lamour JM, Kanter KR, Naftel DC, et al. Cardiac Transplant Registry Database; Pediatric Heart Transplant Study. The effect of age, diagnosis, and previous surgery in children and adults undergoing heart transplantation for congenital heart disease. J Am Coll Cardiol 2009; 54: 160-5.
3. Delgado JF, Gómez-Sánchez MA, Sáenz de la Calzada C, et al. Impact of mild pulmonary hypertension on mortality and pulmonary artery pressure profile after heart transplantation. J Heart Lung Transplant 2001; 20: 942-8.
4. Hoskote A, Carter C, Rees P, Elliott M, Burch M, Brown K. Acute right ventricular failure after pediatric cardiac transplant: predictors and long-term outcome in current era of transplantation medicine. J Thorac Cardiovasc Surg 2010; 139(1): 146-53.
5. Huang J, Trinkaus K, Huddleston CB, Mendeloff EN, pray TL, CE C. Risk factors for primary graft failure after pediatric cardiac transplantation: importance of recipient and donor characteristics. J Heart Lung Transplant 2004; 23(6): 716-22.
6. Mitchell MB, Campbell DN, Ivy D, Boucek MM, Sondheimer HM, Pietra B, et al. Evidence of pulmonary vascular disease after heart transplantation for Fontan circulation failure. J Thorac Cardiovasc Surg 2004; 128(5): 693-702.
7. Zakliczynski M, Zebik T, Maruszewski M, et al. Usefulness of pulmonary hypertension reversibility test with sodium nitroprusside in stratification of early death risk after orthotopic heart transplantation. Transplant Proc 2005; 37: 1346-8.
8. Klotz S, eng MC, Hanafy D, et al. Reversible pulmonary hypertension in heart transplant candidates-pretransplant evaluation and outcome after orthotopic heart transplantation. Eur J Heart Fail 2003; 5(5): 645-53.
9. Mahajan A, Shabanie A, Varshney SM, Marijic J, MJ S. Inhaled nitric oxide in the preoperative evaluation of pulmonary hypertension in heart transplant candidates. J Cardiothorac Vasc Anest 2007; 21(1): 51-6.
10. Balzer DT, Kort HW, Day RW, et al. Inhaled Nitric Oxide as a Preoperative Test (INOP Test I): the INOP Test Study Group. Circulation. 2002; 106: I76-I81.
11. Jabbour A, Keogh A, Hayward C, Macdonald P. Chronic sildenafil lowers transpulmonary gradient and improves cardiac output allowing successful heart transplantation. Eur J Heart Fail 2007; 9(6-7): 674-7.
12. Sansone F. Oral sildenafil: potential role in heart transplantation. Review of the literature and personal experience. J Cardiol 2010; 55(3): 291-5.
13. Humpl T, Reyes JT, Holtby H, Stephens D, Adatia I. Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, openlabel, pilot study. Circulation. 2005; 111(24): 3274-80.
14. Apostolopoulou SC, Manginas A, Cokkinos DV, et al. Effect of the oral endothelin antagonist bosentan on the clinical, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease. Heart 2005; 91: 1447-52.
15. Pamboukian SV, Carere RG, Webb JG, et al. The use of milrinone in pre-transplant assessment of patients with congestive heart failure and pulmonary hypertension. J Heart Lung Transplant 1999; 18(4): 367-71.
16. Torres Macho J, Delgado Jimenez JF, Sanz Salvo J, et al. Effect of different pharmacologic agents to reverse severe pulmonary hypertension among end-stage heart failure patients. Transplant Proc 2009; 41(6): 2477-9.
17. Dewey Jr. CF, Bussolari S, Gimbrone Jr. MA, et al. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng 1981; 1-3: 177-85.
18. Flaherty JT, Pierce JE, Ferrans VJ, et al. Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events. Circ Res 1972; 30: 23-33.
19. Langille BL, Adamson SL. Relationship between blood flow direction and endothelial cell orientation at arterial branch sites in rabbits and mice. Circ Res 1981; 48: 481-8.
20. Levesque M, Liepsch D, Moravec S. Correlation of endothelial cell shape and wall shearstress in a stenosed dog aorta. Arteriosclerosis. 1986; 6: 220-9.
21. Okano M, Yoshida Y. Endothelial cell morphometry of atherosclerotic lesions and flow profiles at aortic bifurcations in cholesterol-fed rabbits. J Biomech Eng 1992; 114: 301-8.
22. Okano M, Yoshida Y. Influence of shear stress on endothelial cell shapes and junction complexes at flow dividers of aortic bifurcations in cholesterol-fed rabbits. Front Med Biol Eng 1993; 5: 95-120.
23. Barbee KA, Davies PF, Lal R. Shear stress induced reorganization of the surface topography of living endothelial cells imaged by atomic force microscopy. Circ Res 1994; 74: 163-71.
24. Traub O, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler. Thromb Vasc Biol 1998; 18: 677-85.
25. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev 1995; 75: 519-60.
26. Berthiaume F, Frangos JA. Fluid flow increases membrane permeability to merocyanine 540 in human endothelial cells. Biochim Biophys Acta 1994; 1191: 209-18.
27. Kung CE, Reed JK. Microviscosity measurements of phospholipids bilayers using fluorescent dyes that undergo torsional relaxation. Biochemistry 1986; 25: 6114-21.
28. Kapitulnik J, Weil E, Rabinowitz R, et al. Fetal and adult human liver differ markedly in the fluidity and lipid composition of their microsomal membranes. Hepatology. Hepatology 1987; 7: 55-60.
29. Dunham WR, Sands RH, Klein SB, et al. EPR measurements showing that plasma membrane viscosity can vary from 30 to 100 cP in human epidermal cell strains. Spectrochim Acta 1996; A52: 1357-68.
30. Cohen MH, Turnbull D. Molecular transport in liquids and glasses. J Chem Phys 1959; 31.
31. Doolittle AK. Studies in Newtonian flow. II. The dependence of the viscosity of liquids on free-space. J Appl Phys 1951; 22: 1471-5.
32. Haidekker M, L'Heureux N, Frangos JA. Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence. Am J Physiol 2000; 278: H1401-H6.
33. Haidekke M, White CR, L'Heureux N, et al. Analysis of temporal shear stress gradients during the onset phase of flow over a backward-facing step. Implications on endothelia cell proliferation. J Biomech Eng 2001; 123: 455-63.
34. Gudi SRP, Nolan JP, Frangos JA. a Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition. Proc Natl Acad Sci USA 1998; 95: 2515-9.
35. Hanggi P, Talkner P, Borkovec M. Reaction-rate theory-50 years after Kramers. Rev Modern Phys 1990; 62: 251-341.
36. Beece D, Eisenstein L, Frauenfelder H, et al. Solvent viscosity and protein dynamics. Biochemistry 1980; 19: 5147-57.
37. Berthiaume F, Frangos JA. Flow-induced prostacyclin production is mediated by a pertussis toxinsensitive G-protein. FEBS Lett 1992; 30: 277-9.
38. Hsieh HJ, Li NQ, Frangos JA. Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase-C. J Cell Physiol Rev 1992; 150: 552-8.
39. Kuchan MJ, Jo H, Frangos JA. Role of G proteins in shear stressmediated nitric oxide production by endothelial cells. Am J Physiol 1994; 267: C753-C8.
40. Frangos JA, Huang TY, Clark CB. Steady shear and step changes in shear stimulate endothelium via independent mechanisms-superposition of transient and sustained nitric oxide production. Biochem Biophys Res Commun 1996; 224: 660-5.
41. Gudi SRP, Clark CB, Frangos JA. Fluid flow rapidly activates G proteins in human endothelial cells Circ Res 1996; 79: 834-9.
42. White CR, Frangos JA. The shear stress of it all: the cell membrane and mechanochemical transduction Philos Trans R Soc Lond B Biol Sci 2007; 362: 1459-67.
43. Storme L, Parker TA, Kinsella JP, et al. Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung. Am J Physiol Lung Cell Mol Physiol 2002; 2823: L56-L66.
44. Ross GA, Oishi P, Azakie A, et al. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. Am J Physiol Lung Cell Mol Physiol 2005; 288: L27-L35.
45. Rondelet B, Kerbaul F, Van Beneden R, et al. Prevention of pulmonary vascular remodeling and of decreased BMPR-2 expression by losartan therapy in shunt-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 2005; 289: H2319-H24.
46. Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, JR F. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. Am J Physiol Heart Circ Physiol 2001; 280(1): H311-H7.
47. Rabinovitch M, Konstam MA, Gamble WJ, et al. Changes in pulmonary blood flow affect vascular response to chronic hypoxia in rats. Circ Res 1983; 52(4): 432-41.
48. Li M, Stenmark KR, Shandas R, Tan W. Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors. J Vasc Res 2009; 46(6): 561-71.
49. Delgado JF, Conde E, Sánchez V, et al. Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure. Eur J Heart Fail 2005; 7: 1011-6.
50. Rabinovitch M, Haworth SG, Castaneda AR, et al. Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease. Circulation 1978; 58: 1107-22.
51. Rabinovitch M, Keane JF, Norwood WI, et al. Vascular structure in lung tissue obtained at biopsy correlated with pulmonary hemodynamic findings after repair of congenital heart defects. Circulation 1984; 69: 655-67.
52. Heath D, Edwards JE. The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects. Circulation 1958; 18: 533-47.
53. Ross R, Glomset A, Kariya B, et al. A platelet dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci 1974; 71: 1207.
54. Meyrick B, Reid L. Ultrastructural findings in lung biopsy material from children with congenital heart defects. Am J Pathol 1980; 101: 527.
55. Fishman JA, Ryan FB, Karnovsky MJ. Endothelial regeneration in the rat carotid artery and the significance of endothelial denudation in the pathogenesis of myointimal thickening. Lab Invest 1975; 32: 339.
56. Harker LA, Ross R, Slichter SJ, et al. Homocystine-induced arteriosclerosis: the role of endothelial cell injury' and platelet responsein its genesis. J Clin Invest 1976; 5s: 731.
57. Gajarski RJ, Towbin JA, Bricker JT, et al. Intermediate follow-up of pediatric heart transplant recipients with elevated pulmonary vascular resistance index. J Am Coll Cardiol 1994; 23: 1682-7.
58. Deng MC, Gradaus R, Hammel D, et al. Heart transplant candidates at high risk can be identified at the time of initial evaluation. Transpl Int 1996; 9: 38-45.
59. Zimpfer D, Zrunek P, Roethy W, et al. Left ventricular assist devices decrease fixed pulmonary hypertension in cardiac transplant candidates. J Thorac Cardiovasc Surg 2007; 133: 689-95.
60. Kaye MP. The Registry of the International Society for Heart and Lung Transplantation: ninth official report-1992. J Heart Lung Transplant 1992; 11: 599-606.
61. Wang SS, Chu SH, Ko WJ, et al. Heterotopic heart transplantation for severe pulmonary hypertension. Transplant Proc 1998; 30: 3408-9.
62. Elefteriades JA, Lovoulos CJ, Tellides G, et al. Right ventriclesparing heart transplant: promising new technique for recipients with pulmonary hypertension. Ann Thorac Surg 2000; 69: 1858-63; discussion 63-4.
63. Lovoulos C, Tittle S, Goldstein L, et al. Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension. J Heart Lung Transplant 2004; 23: 236-41.
64. Birks EJ, Yacoub MH, Anyanwu A, et al. Transplantation using hearts from primary pulmonary hypertensive donors for recipients with a high pulmonary vascular resistance. J Heart Lung Transplant 2004; 23: 1339-44.
65. O'Blenes SB, Fischer S, McIntyre B, et al. Hemodynamic unloading leads to regression of pulmonary vascular disease in rats. J Thorac Cardiovasc Surg 2001; 121: 279-89.
66. Etz CD, Welp HA, Tjan TD, et al. Medically refractory pulmonary hypertension: treatment with nonpulsatile left ventricular assist devices. Ann Thorac Surg 2007; 83: 1697-709.
67. Zimpfer D, Zrunek P, Roethy W, et al. Left ventricular assist devices decrease fixed pulmonary hypertension in cardiac transplant candidates. J Thorac Cardiovasc Surg 2007; 133: 689-95.
68. Gallagher RC, Kormos RL, Gasior T, et al. Univentricular support results in reduction of pulmonary resistance and improved right ventricular function. ASAIO Transplant 1991; 37: M287-M8.
69. Smedira NG, Massad MG, Navia J, et al. Pulmonary hypertension is not a risk factor for RVAD use and death after left ventricularassist system support. ASAIO J 1996; 42: M733-M5.
70. Baldovinos A, Kalangos A, Sierra J, et al. Is partially reversiblepulmonary hypertension a contraindication for heart transplantation?. Transplant Proc 2000; 32: 468-9.
71. Petrofski JA, Hoopes CW, Bashore TM, et al. Mechanical ventricular support lowers pulmonary vascular resistance in a patient with congential heart diseas. Ann Thorac Surg 2003; 75: 1005-7.
72. Martin J, Siegenthaler MP, et al. Implantable left ventricular assist device for treatment of pulmonary hypertension in candidates for orthotopic heart transplantation-a preliminary study. Eur J Cardiothorac Surg 2004; 25: 971-7.
73. Al-Khaldi A, Ergina P, DeVarennes B, et al. Left ventricular unloading in a patient with end-stage cardiomyopathy and medically unresponsive pulmonary hypertension. Artif Organs 2004; 28: 158-60.
74. Choong CK, Pasque MK, Shelton K, et al. The beneficial role of left ventricular assist device destination therapy in the reversal of contraindications to cardiac transplantation. J Thorac Cardiovasc Surg 2005; 130: 879-80.
75. Haddad H, Elabbassi W, Moustafa S, et al. Left ventricular assist device as bridge to heart transplantation in congestive heart failure with pulmonary hypertension. ASAIO J 2005; 51: 456-60.
76. Salzberg SP, Lachat ML, von Harbou K, et al. Normalization of high pulmonary vascular resistance with LVAD support in heart transplantation candidates. Eur J Cardiothorac Surg 2005; 27: 222-5.
77. Zimpfer D, Zrunek P, Sandner S, et al. Posttransplant survival after lowering fixed pulmonary hypertension using left ventricular assist devices. Eur J Cardiothorac Surg 2007; 31: 698-702.
78. Gandhi SK, Grady RM, Huddleston CB, et al. Beyond Berlin: heart transplantation in the untransplantable. J Thorac Cardiovasc Surg 2008; 136: 529-31.
79. Gandhi SK, Huddleston CB, Balzer DT, et al. Biventricular assist devices as a bridge to heart transplantation in small children. Circulation 2008; 118: S89-S93.
80. Gazit AZ, Oren PP. Pharmaceutical management of decompensated heart failure syndrome in children: current state of the art and a new approach. Curr Treat Options Cardiovasc Med 2009; 11: 403-9.
81. K Simpson*a, C Canter, C Lee, et al. Failed Fontan Heart Transplant Candidates with Preserved Versus Impaired Ventricular Ejection: 2 Distinct Patient Populations. The Journal of Heart and Lung Transplantation 2011; 30: S167.
82. Reinhardt Z, Uzun O, Bhole V, et al. Sildenafil in the management of the failing Fontan circulation. Cardiol Young 2010; 20: 522-5.
83. Giardini A, Balduci A, Specchia S, et al. Effect of Sildenafil on haemodynamic response to exercise and exercise capacity in Fontan patients. Eur Heart J 2008; 29: 1681-7.
84. Frazier OH, Gregoric ID, Messner GN. Total circulatory support with an LVAD in an adolescent with a previous Fontan procedure. Tex Heart Inst J 2005; 8(32): 402-4.
85. Nathan M, Baird C, Fynn-Thompson F, et al. Successful implantation of a Berlin heart biventricular assist device in a failing single ventricle. J Thorac Cardiovasc Surg 2006; 131: 1407-8.
86. Newcomb AE, Negri JC, Brizard CP, et al. Successful left ventricular assist device bridge to transplantation after failure of a fontan Fontan revision. J Heart Lung Transplant 2006; 25: 365-7.
87. Chen JM, Davies RR, Mital SR, et al. Trends and outcomes in transplantation for complex congenital heart disease: 1984 to 2004. Ann Thorac Surg 2004; 78: 1352-61.
88. Kanter KR, Vincent RN, Raviele AA. Importance of acquired systemic-to-pulmonary collaterals in the Fontan operation. Ann Thorac Surg. 1999; 68: 969-75.
89. Krishnan US, Lamour DT, Hsu DT, et al. Management of aortopulmonary collaterals in children following cardiac transplantation for complex congenital heart disease J Heart Lung Transplant 2004; 23: 948-53.
90. Pesonen E, Haavisto H, Ammala P, et al. Intrauterine hydrops caused by premature closure of the foramen ovale. Arch Dis Child 1983; 58: 1015-6.
91. Moerman PL, Van Dijck H, Lauweryns JM, et al. Premature closure of the foramen ovale and congenital pulmonary cystic lymphangiectasis in aortic valve atresia or in severe aortic valve stenosis. Am J Cardiol 1986; 57: 703-5.
92. Rychik J, ome JJ, Collins MH, et al. The hypoplastic left heart syndrome with intact atrial septum: atrial morphology, pulmonary vascular histopathology and outcome. J Am Coll Cardiol 1999; 34: 554-60.
93. Canter CE, Shaddy RE, Bernstein D, et al. American Heart Association Council on Cardiovascular Disease in the Young; American Heart Association Council on Clinical Cardiology; American Heart Association Council on Cardiovascular Nursing; American Heart Association Council on Cardiovascular Surgery and Anesthesia; Quality of Care and Outcomes Research Interdisciplinary Working Group. Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 2007; 115: 658-76.