Catalytic intermolecular hetero-dehydro-diels-alder cycloadditions: Regioand diasteroselective synthesis of 5,6-dihydropyridin-2-ones

Organic Letters

Volumn 13, Issue 19, 2011, Pages 5172-5175

  Fernández García, Jesús Manuel ^a   Fernández Rodríguez, Manuel Á ^b   Aguilar, Enrique ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b UNIVERSITY OF BURGOS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CYCLIZATION; STEREOISOMERISM; SYNTHESIS;

CATALYSIS; CYCLIZATION; DIHYDROPYRIDINES; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 80054726066     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol202046y     Document Type: Article

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46. Dihydropyridines 14a,b were isolated in just 29% and 13% yield in preliminary reactions carried out between dienyne 1a and N-trimethylsilyl benzaldimines 12a,b. The low yield of 14, probably due to product decomposition during chromatographic purification, prompted us to perform an in situ additional hydrolysis step.