RP101 (Brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 9, 2011, Pages 1349-1361

  Heinrich, Jörg Christian ^a   Tuukkanen, Anne ^b   Schroeder, Michael ^b   Fahrig, Torsten ^a   Fahrig, Rudolf ^a  

^a RESprotect   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Chemoresistance; Chemotherapy; HSP27 (HSPB1); Molecular chaperones; Pancreatic cancer

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYURIDINE; CASPASE 9; CISPLATIN; DOXORUBICIN; GEMCITABINE; GLUFOSFAMIDE; HEAT SHOCK PROTEIN 27; PLACEBO;

ADD ON THERAPY; ADULT; AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CANCER SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG TARGETING; FEMALE; GENETIC TRANSCRIPTION; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PANCREAS CANCER; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RANDOMIZED CONTROLLED TRIAL; RAT; RNA TRANSLATION; STRUCTURE ANALYSIS; SURVIVAL TIME;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; BROMODEOXYURIDINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG EVALUATION, PRECLINICAL; FEMALE; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MALE; MIDDLE AGED; MODELS, MOLECULAR; PANCREATIC NEOPLASMS; PILOT PROJECTS; PLACEBOS; RATS; RATS, SPRAGUE-DAWLEY; SARCOMA; SURVIVAL ANALYSIS;

EID: 80054720155     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1005-1     Document Type: Article

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