Altered expression of anti-apoptotic proteins in non-involved tissue from cancer-containing breasts

Breast Cancer Research and Treatment

Volumn 114, Issue 1, 2009, Pages 63-69

  Batchelder, A J ^a   Gordon Weeks, A N ^a   Walker, R A ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Apoptosis; Bcl2; Breast cancer development; Hsp27; Normal breast

Indexed keywords

ATM PROTEIN; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; PROTEIN BAX; PROTEIN BCL 2;

ADULT; AGED; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPAIR; FEMALE; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; APOPTOSIS REGULATORY PROTEINS; BREAST; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL;

EID: 58849117683     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-9988-2     Document Type: Article

References (44)

1. PT Simpson JS Reis-Filho T Gale 2005 Molecular evolution of breast cancer J Pathol 205 248 254
2. FW Foote FW Stewart 1945 Comparative studies of cancerous versus noncancerous breasts Ann Surg 121 197 222
3. SR Wellings HM Jensen RG Marcum 1975 An atlas of subgross pathology of the human breast with special reference to precancerous lesions J Natl Cancer Inst 55 231 273
4. CE Alpers SR Wellings 1985 The prevalence of carcinoma in situ in normal and cancer associated breasts Hum Pathol 16 796 807
5. DL Page R Vander Zwaag LW Rogers 1978 Relation between component parts of fibrocystic disease complex and breast cancer J Natl Cancer Inst 61 1055 1063
6. WD Dupont DL Page 1985 Risk factors for breast cancer in women with proliferative disease New Eng J Med 312 146 151
7. DL Page WD Dupont 1990 Anatomic markers of human premalignancy and risk of breast cancer Cancer 66 1326 1335
8. FA Tavassoli AJ Norris 1990 A comparison of the results of long-term follow-up for atypical ductal hyperplasia and intraduct hyperplasia of the breast Cancer 65 518 529
9. RW McDivitt JA Stevens NC Lee 1992 Histologic types of benign breast disease and the risk of breast cancer Lancet 69 1408 1414
10. SJ London JL Connolly SJ Schnitt 1992 A prospective study of benign breast disease and the risk of breast cancer J Am Med Assoc 267 941 944
11. J Wang JP Constantino E Tan-Chin 2004 Lower category benign breast disease and the risk of invasive breast cancer J Natl Cancer Inst 96 616 620
12. DP Slaughter HW Southwick W Smejkal 1953 Field cancerisation in oral stratified squamous epithelium: clinical implications of multicentric origin Cancer 6 963 968
13. BJM Braakhuis MP Tabor JA Kummer 2003 A genetic explanation of Slaughter's concept of field cancerisation: evidence and clinical implications Cancer Res 63 1727 1730
14. G Deng Y Lu G Zlotnikov 1996 Loss of heterozygosity in normal tissue adjacent to breast carcinomas Science 274 2057 2059
15. PS Larson A de las Morenas LA Cupples 1998 Genetically abnormal clones in histologically normal breast tissue Am J Pathol 152 1591 1598
16. SR Lakhani R Chaggar S Davies 1999 Genetic alterations in 'normal' luminal and myoepithelial cells of the breast J Pathol 189 496 503
17. PS Larson A de las Morenas SR Bennett 2002 Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas Am J Pathol 161 283 290
18. TD Tlsty YG Crawford CR Holst 2004 Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis J Mammary Gland Biol Neoplasia 9 263 274
19. DL Ellsworth RE Ellsworth MN Liebman 2004 Genomic instability in histologically normal breast tissues: implications for carcinogenesis Lancet Oncol 5 753 758
20. PS Larson BL Schlecter de las Morenas 2005 Allele imbalance, or loss of heterozygosity, in normal breast epithelium of sporadic breast cancer cases and BRCA1 gene mutation carriers is increased compared with reduction mammoplasty tissues J Clin Oncol 23 8613 8619
21. RA Walker J Cowl PPS Dhadly 1992 Oestrogen receptor, epidermal growth factor receptor and oncoprotein expression in non-involved tissue of cancerous breasts Breast 2 87 91
22. JL Jones DR Critchley RA Walker 1992 Alteration of integrin and stromal protein expression-a marker of pre-malignant change J Pathol 167 399 406
23. HI Hassan RA Walker 2001 Altered expression of epidermal growth factor receptor in non-involved tissue of cancer-containing breasts Breast 10 318 324
24. HI Hassan RA Walker 1998 Decreased apoptosis in non-involved tissue from cancer-containing breasts J Pathology 184 258 264
25. DJ Allan A Howell SA Roberts 1992 Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast J Pathol 167 25 32
26. RB Clarke A Howell CS Potten 1997 Dissociation between steroid receptor expression and cell proliferation in the human breast Cancer Res 57 4987 4991
27. BS Shoker C Jarvis RB Clarke 1999 Estrogen receptor-positive proliferating cells in the normal and precancerous breast Am J Pathol 155 1811 1815
28. JM Adams S Cory 2007 The Bcl-2 apoptotic switch in cancer development and therapy Oncogene 26 1324 1337
29. K Schorr M Li U Bar-Peled 1999 Gain of Bcl-2 is more potent than BAX loss in regulating mammary epithelial cell survival in vivo Cancer Res 59 2541 2545
30. JC Sabourin A Martin J Baruch 1994 Bcl-2 expression in normal breast during the menstrual cycle Int J Cancer 59 1 6
31. A Gompel S Somai M Chaout 2000 Hormonal regulation of apoptosis in breast cells and tissues Steroids 65 593 598
32. JM Gee JFR Robertson IO Ellis 1994 Immunocytochemical localization of bcl-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy Int J Cancer 59 619 628
33. DR Ciocca S Oesterreich GC Chamness 1993 Biological and clinical implications of heat shock protein 27,000 (Hsp27): a review J Natl Cancer Inst 85 1558 1570
34. CG Concannon AM Gorman A Samali 2003 On the role of Hsp27 in regulating apoptosis Apoptosis 8 61 70
35. H Konishi H Matsuzaki M Tamaka 1997 Activation of protein kinase B (AKT/RAC-protein kinase) by cellular stress and its association with heat shock protein HSP27 FEBS Lett 410 493 498
36. PA O'Neill AM Shaaban CR West 2004 Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27 Br J Cancer 90 182 188
37. J Taylor M Lymboura PE Pace 1998 An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers Int J Cancer 79 334 342
38. H Lambie A Miremadi SE Pinder 2003 Prognostic significance of BRCA1 expression in sporadic breast carcinomas J Pathol 200 207 213
39. S Angele I Treilleux P Taniere 2000 Abnormal expression of the ATM and P53 genes in sporadic breast carcinomas Clin Cancer Res 6 3536 3544
40. S Angele I Treilleux A Bremond 2003 Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas Histopathology 43 347 353
41. S Angele C Jones JS Reis Filho 2004 Expression of ATM, p53 and the MRE11-Rad50-NBSI complex in myoepithelial cells from benign and malignant proliferations of the breast J Clin Pathol 57 1179 1184
42. RA Clarke R Kairouz D Watters 1998 Upregulation ATM in sclerosing adenosis of the breast Mol Pathol 51 224 226
43. PS Yan C Venkataramu A Ibrahim 2006 Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue Clin Cancer Res 12 6626 6636
44. CJ Fabian BF Kimler MS Mayo 2005 Breast-tissue sampling for risk assessment and prevention Endocr Res Cancer 12 185 213