Oncolytic adenoviruses armed with thymidine kinase can be traced by pet imaging and show potent antitumoural effects by ganciclovir dosing

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Abate Daga, Daniel ^a,b   Andreu, Nuria ^b,c   Camacho Sánchez, Juan ^d   Alemany, Ramon ^d   Herance, Raúl ^e   Millán, Olga ^e   Fillat, Cristina ^a,b,c  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^e Barcelona Biomedical Research Park   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYL 2' FLUOROURACIL ARABINOSIDE F 18; GANCICLOVIR; ONCOLYTIC ADENOVIRUS; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ONCOLYTIC VIRUS;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE TRACING; MOLECULAR IMAGING; MOUSE; NONHUMAN; ONCOLYTIC VIROTHERAPY; PANCREAS CANCER; POSITRON EMISSION TOMOGRAPHY; PROMOTER REGION; SINGLE DRUG DOSE; ANIMAL; DRUG EFFECT; DRUG SCREENING; GENETICS; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; SCINTISCANNING; TUMOR CELL LINE; VIRUS REPLICATION;

ADENOVIRIDAE;

ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GANCICLOVIR; HUMANS; MICE; ONCOLYTIC VIRUSES; PANCREATIC NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PROMOTER REGIONS, GENETIC; THYMIDINE KINASE; VIRUS REPLICATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80054718262     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026142     Document Type: Article

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