Evaluation of 76Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma

Journal of Nuclear Medicine

Volumn 46, Issue 11, 2005, Pages 1923-1930

  Cho, Steve Y ^a   Ravasi, Laura ^b,c,d   Szajek, Lawrence P ^b   Seidel, Jurgen ^b   Green, Michael V ^b   Fine, Howard A ^a   Eckelman, William C ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF MILAN   (Italy)

^d NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

76Br FBAU; Glioma; Herpes simplex virus type 1 thymidine kinase; Small animal PET

Indexed keywords

2' FLUORO 2' DEOXY 5 IODOURACIL BETA D ARABINOFURANOSIDE C 14; 5 BROMO 2' FLUORO 2' DEOXYURIDINE BR 76; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; TRACER; UNCLASSIFIED DRUG; VIRUS ENZYME; 1 (2 FLUORO 2 DEOXYARABINOFURANOSYL) 5 BROMOURACIL; 1-(2-FLUORO-2-DEOXYARABINOFURANOSYL)-5-BROMOURACIL; 5 BROMOURACIL; DIAGNOSTIC AGENT; DRUG DERIVATIVE; RECOMBINANT PROTEIN; THYMIDINE KINASE, CANID HERPESVIRUS 1; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; GENE EXPRESSION; GLIOMA; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; MOLECULAR IMAGING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RAT; REPORTER GENE; ANIMAL; ANTIBODY SPECIFICITY; DISEASE MODEL; DRUG SCREENING; EVALUATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PROCEDURES; GENETIC TRANSFECTION; GENETICS; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; NUDE MOUSE; SCINTISCANNING; TISSUE DISTRIBUTION;

ANIMALS; BROMOURACIL; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GLIOMA; HUMANS; METABOLIC CLEARANCE RATE; MICE; MICE, NUDE; MOLECULAR PROBE TECHNIQUES; ORGAN SPECIFICITY; RADIOPHARMACEUTICALS; RECOMBINANT PROTEINS; THYMIDINE KINASE; TISSUE DISTRIBUTION; TRANSFECTION; VIRAL PROTEINS;

EID: 33644830510     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Gambhir SS, Barrio JR, Herschman HR, Phelps ME. Assays for noninvasive imaging of reporter gene expression. Nucl Med Biol. 1999;26:481-490.
2. Gambhir SS, Herschman HR, Cherry SR, et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia. 2000;2:118-138.
3. Blasberg R. PET imaging of gene expression. Eur J Cancer. 2002;38:2137-2146.
4. Gambhir SS, Bauer E, Black ME, et al. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci USA. 2000;97:2785-2790.
5. Liang Q, Nguyen K, Satyamurthy N. Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene. Gene Ther. 2002;9:1659-1666.
6. 124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur J Nucl Med. 2001;28:721-729.
7. Tjuvajev JG, Doubrovin M, Akhurst T. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med. 2002;43:1072-1083.
8. 14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection. Eur J Nucl Med Mol Imaging. 2003;30:1547-1560.
9. 76Br]bromo-2′-fluoro-2′- deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model. Eur J Nucl Med Mol Imaging. 2002;29: 19-27.
10. 76Br]bromofluoride-oxyuridine and its validation with regard to uptake, DNA incorporation, and excretion modulation in rats. J Nucl Med. 2000;41:1746-1752.
11. Watkins AM, Dunford PJ, Moffatt AM, et al. Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo. Antivir Chem Chemother. 1998;9:9-18.
12. 76Br-BFU as proliferation markers. J Nucl Med. 2002;43:1688-1698.
13. Szajek LP, Kao CHK, Kiesewetter DO, et al. Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies. Radiochimica ACTA. 2004;92:291-295.
14. McGrory WJ, Bautista DS, Graham FL. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology. 1988;163:614-617.
15. Green MV, Seidel J, Vaquero JJ, Jagoda E, Lee I, Eckelman WC. High resolution PET, SPECT and projection imaging in small animals. Comput Med Imaging Graph. 2001;25:79-86.
16. Seidel J, Vaquero JJ, Lee IJ, Green MV. Experimental estimates of the absolute sensitivity of a small animal PET scanner with depth-of-interaction capability. Nuclear Science Symposium Conference Record, Lyon, France, October 15-20, 2000. Piscataway, NJ: IEEE. 2000;3:57-59.
17. Gambhir SS, Barrio JR, Phelps ME, et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci USA. 1999;96:2333-2338.
18. Gambhir SS, Barrio JR, Wu L, et al. Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J Nucl Med. 1998;39:2003-2011.
19. Tjuvajev JG, Chen SH, Joshi A, et al. Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res. 1999;59: 5186-5193.
20. Doubrovin M, Ponomarev V, Beresten T, et al. Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci USA. 2001;98:9300-9305.
21. Imperiale MJ, Kochanek S. Adenovirus vectors: biology, design, and production. Curr Top Microbiol Immunol. 2004;273:335-357.
22. Volpers C, Kochanek S. Adenoviral vectors for gene transfer and therapy. J Gene Med. 2004;6(suppl 1):S164-S171.
23. Chen W, Lee J, Cho SY, Fine HA. Proteasome-mediated destruction of the cyclin a/cyclin-dependent kinase 2 complex suppresses tumor cell growth in vitro and in vivo. Cancer Res. 2004;64:3949-3957.
24. Manome Y, Wen PY, Dong Y, et al. Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat Med. 1996;2:567-573.
25. Tjuvajev JG, Stockhammer G, Desai R, et al. Imaging the expression of transfected genes in vivo. Cancer Res. 1995;55:6126-6132.
26. Tjuvajev JG, Avril N, Oku T, et al. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res. 1998;58: 4333-4341.
27. 18F]labeled FAU, FMAU, FBAU, FIAU. Nucl Med Biol. 2003;30: 215-224.
28. 18F]-FCAU), and their biological evaluation as markers for gene expression. Nucl Med Biol. 2004;31:399-405.