Case Study: Biodegradable Microspheres for the Sustained Release of Proteins: Guidelines for Formulating and Processing Dry Powder Pharmaceutical Products

Injectable Dispersed Systems: Formulation, Processing, and Performance

Volumn , Issue , 2005, Pages 571-581

  Tracy, Mark A ^a  

^a ALKERMES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80054715456     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (15)

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4. Johnson OL, Jaworowicz W, Cleland JL, Bailey L, Charnis M, Duenas E, Wu C, Shepard D, Magil S, Last T, Jones AJS, Putney SD. The stabilization and encapsulation of human growth hormone into biodegradable microspheres. Pharm Res 1997; 14:730-735.
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9. Hancock BC, Shamblin SL, Zografi G. Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm Res 1995; 12:799-806.
10. Edwards DA, Hanes J, Caponetti G, Hrkach J, Ben-Jebria A, Eskew ML, Mintzes J, Deaver D, Lotan N, Langer R. Large porous particles for pulmonary drug delivery. Science 1997; 276:1868-1871.
11. Siegel RA, Langer R. Controlled release of polypeptides and other macromolecules. Pharm Res 1984; 1:2-10.
12. Bawa R, Siegel RA, Marasca B, Karel M, Langer R. An explanation for the controlled release of maromolecules from polymors. J Contr Rel 1985; 1:259-267.
13. Saltzman WM, Langer R. Transport rates of proteins in porous materials with known microgeometry. Biophys J 1989; 55:163-171.
14. Costantino HR, Firouzabadian L, Hogeland K, Wu C, Beganski C, Carrasquillo KG, Cordova M, Griebenow K, Zale SE, Tracy MA. Protein spray-freeze drying. Effect of atomization conditions on particle size and stability. Pharm Res 2000; 17:1374-1383.
15. Costantino HR, Firouzabadian L, Wu C, Carrasquillo KG, Griebenow K, Zale SE, Tracy MA. Protein spray-freeze drying. Effect of formulation variables on particle size and stability. J pharm Sci 2002; 91:388-395.