Insights into folate/FAD-dependent tRNA methyltransferase mechanism: Role of two highly conserved cysteines in catalysis

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36268-36280

  Hamdane, Djemel ^a   Argentini, Manuela ^b   Cornu, David ^b   Myllykallio, Hannu ^c   Skouloubris, Stéphane ^c   Hui Bon Hoa, Gaston ^d   Golinelli Pimpaneau, Béatrice ^a  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^b CNRS   (France)

^c LABORATOIRE D OPTIQUE ET BIOSCIENCES   (France)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BACILLUS SUBTILIS; BIOPHYSICAL CHARACTERIZATION; CATALYTIC MECHANISMS; COVALENT COMPLEX; DOUBLE MUTANTS; GEL MOBILITY SHIFT ASSAY; GENERAL BASE; IN-VITRO; METHYLTRANSFERASES; S ADENOSYL L METHIONINES; THYMIDYLATE SYNTHASE; WILD-TYPE ENZYMES;

BACTERIOLOGY; CATALYSIS; ENZYMES; KETONES; NUCLEOPHILES; PHENOLS; QUANTUM CHEMISTRY; RNA;

AMINO ACIDS;

ALANINE; CYSTEINE; FLAVINE ADENINE NUCLEOTIDE; FOLIC ACID; QUERCETIN; TRANSFER RNA; TRANSFER RNA METHYLTRANSFERASE;

ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; GEL MOBILITY SHIFT ASSAY; MUTATION; NONHUMAN; PRIORITY JOURNAL; RNA BINDING; RNA METHYLATION; WILD TYPE;

AMINO ACID SUBSTITUTION; BACILLUS SUBTILIS; BACTERIAL PROTEINS; FLAVIN-ADENINE DINUCLEOTIDE; METHYLATION; MUTATION, MISSENSE; RNA, BACTERIAL; RNA, TRANSFER; TRNA METHYLTRANSFERASES;

BACILLUS SUBTILIS;

EID: 80054714992     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.256966     Document Type: Article

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