Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia

BMC Medical Genetics

Volumn 12, Issue , 2011, Pages

  Mujakovic, Suhreta ^a   ter Linde, José J M ^a   de Wit, Niek J ^a   van Marrewijk, Corine J ^b   Fransen, Gerdine A J ^c   Onland Moret, N Charlotte ^a   Laheij, Robert J F ^b   Muris, Jean W M ^c   Grobbee, Diederick E ^a   Samsom, Melvin ^a   Jansen, Jan B M J ^b   Knottnerus, André ^c   Numans, Mattijs E ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTACID AGENT; SEROTONIN 3 RECEPTOR; HTR3A PROTEIN, HUMAN; SEROTONIN TRANSPORTER;

ARTICLE; CAUCASIAN; DISEASE ASSOCIATION; DISEASE SEVERITY; DYSPEPSIA; GENE DELETION; GENE INSERTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PROTEIN POLYMORPHISM; SEX DIFFERENCE; ADULT; CROSS-SECTIONAL STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HOSPITALIZATION; INDEL MUTATION; MALE; MIDDLE AGED; MULTICENTER STUDY (TOPIC); PREVALENCE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADULT; CROSS-SECTIONAL STUDIES; DYSPEPSIA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDEL MUTATION; MALE; MIDDLE AGED; MULTICENTER STUDIES AS TOPIC; POLYMORPHISM, GENETIC; PREVALENCE; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 80054710685     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-12-140     Document Type: Article

References (54)

1. Van Bommel MJ, Numans ME, de Wit NJ, Stalman WA. Consultations and referrals for dyspepsia in general practice--a one year database survey. Postgrad Med J 2001, 77:514-8. 10.1136/pmj.77.910.514, 1742094, 11470932.
2. Maconi G, Tosetti C, Stanghellini V, Bianchi Porro G, Corinaldesi R. Dyspeptic symptoms in primary care. An observational study in general practice. Eur J Gastroenterol Hepatol 2002, 14:985-90. 10.1097/00042737-200209000-00009, 12352218.
3. Meineche-Schmidt V, Krag E. Dyspepsia in general practice in Denmark. A 1-year analysis of consulters in general practice. Scand J Prim Health Care 1998, 16:216-21.
4. El-Serag HB, Talley NJ. Health-related quality of life in functional dyspepsia. Aliment Pharmacol Ther 2003, 18:387-93. 10.1046/j.1365-2036.2003.01706.x, 12940923.
5. Halder SL, Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ. Impact of functional gastrointestinal disorders on health-related quality of life: a population-based case-control study. Aliment Pharmacol Ther 2004, 19:233-42. 10.1111/j.0269-2813.2004.01807.x, 14723614.
6. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998, 115:1346-52. 10.1016/S0016-5085(98)70012-5, 9834261.
7. Kim DY, Delgado-Aros S, Camilleri M, Samsom M, Murray JA, O'Connor MK, Brinkmann BH, Stephens DA, Lighvani SS, Burton DD. Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia. Am J Gastroenterol 2001, 96:3099-3105. 10.1111/j.1572-0241.2001.05264.x, 11721755.
8. Sarnelli G, Caenepeel P, Geypens B, Janssens J, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003, 98:783-8. 10.1111/j.1572-0241.2003.07389.x, 12738456.
9. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia. Gastroenterology 2001, 121:526-35. 10.1053/gast.2001.27180, 11522735.
10. Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998, 42:814-22. 10.1136/gut.42.6.814, 1727129, 9691920.
11. Rhee PL, Kim YH, Son HJ, Kim JJ, Koh KC, Paik SW, Rhee JC, Choi KW. Evaluation of individual symptoms cannot predict presence of gastric hypersensitivity in functional dyspepsia. Dig Dis Sci 2000, 45:1680-4. 10.1023/A:1005550019308, 11007125.
12. Boeckxstaens GE, Hirsch DP, Kuiken SD, Heisterkamp SH, Tytgat GN. The proximal stomach and post-prandial symptoms in functional dyspeptics. Am J Gastroenterol 2002, 97:40-8. 10.1111/j.1572-0241.2002.05421.x, 11811168.
13. Van Oudenhove L, Vandenberghe J, Geeraerts B, Vos R, Persoons P, Fischler B, Demyttenaere K, Tack J. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation?. Gut 2008, 57:1666-73. 10.1136/gut.2008.158162, 18625692.
14. Barry S, Dinan TG. Functional dyspepsia: Are psychosocial factors of relevance?. World J Gastroenterol 2006, 12:2701-7.
15. Holtmann G, Siffert W, Haag S, Mueller N, Langkafel M, Senf W, Zotz R, Talley NJ. G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology 2004, 126:971-9. 10.1053/j.gastro.2004.01.006, 15057736.
16. Camilleri CE, Carlson PJ, Camilleri M, Castillo EJ, Locke GR, Geno DM, Stephens DA, Zinsmeister AR, Urrutia R. A study of candidate genotypes associated with dyspepsia in a U.S. community. Am J Gastroenterol 2006, 101:581-92. 10.1111/j.1572-0241.2006.00481.x, 16464220.
17. Van Lelyveld N, ter Linde JJM, Schipper M, Samsom M. Candidate genotypes associated with functional dyspepsia. Neurogastroenterol Motil 2008, 20:767-73. 10.1111/j.1365-2982.2008.01102.x, 18331431.
18. Tahara T, Shibata T, Yamashita H, Hirata I, Arisawa T. The role of RANTES promoter polymorphism in functional dyspepsia. J Clin Biochem Nutr 2009, 45:235-40. 10.3164/jcbn.09-31, 2735638, 19794934.
19. Tahara T, Shibata T, Wang F, Yamashita H, Hirata I, Arisawa T. Genetic polymorphisms of molecules associated with innate immune responses, TLR2 and MBL2 genes in Japanese subjects with functional dyspepsia. J Clin Biochem Nutr 2010, 47:217-23. 10.3164/jcbn.10-40, 2966931, 21103030.
20. Kendler KS, Gardner CO, Gatz M, Pedersen NL. The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample. Psychological Medicine 2007, 37:453-62. 10.1017/S0033291706009135, 17121688.
21. Tack J, Sarnelli G. Serotonergic modulation of visceral sensation: upper gastrointestinal tract. Gut 2002, 51(Suppl I):i77-80. 1867718, 12077073.
22. Urani A, Chourbaji S, Gass P. Mutant mouse models of depression: Candidate genes and current mouse lines. Neurosci Biobehav Rev 2005, 29:805-28. 10.1016/j.neubiorev.2005.03.020, 15925701.
23. Feinle C, Read NW. Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility. Am J Physiol Gastrointest Liver Physiol 1996, 271:G591-7.
24. Talley NJ, van Zanten SV, Saez LR, Dukes G, Perschy T, Heath M, Kleoudis C, Mangel AW. A dose-ranging, placebo-controlled, randomized trial of alosetron in patients with functional dyspepsia. Aliment Pharmacol Ther 2001, 15:525-37. 10.1046/j.1365-2036.2001.00941.x, 11284782.
25. Rajkumar R, Mahesh R. The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target?. J Psychopharmacol 2010, 24:455-69. 10.1177/0269881109348161, 20123937.
26. Walstab J, Rappold G, Niesler B. 5-HT3 receptors: role in disease and target of drugs. Pharmacol Ther 2010, 128:146-69. 10.1016/j.pharmthera.2010.07.001, 20621123.
27. Niesler B, Flohr T, Nöthen MM, Fischer C, Rietschel M, Franzek E, Albus M, Propping P, Rappold GA. Association between the 5'UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder. Pharmacogenetics 2001, 11:471-5. 10.1097/00008571-200108000-00002, 11505217.
28. Kapeller J, Houghton LA, Mönnikes H, Walstab J, Möller D, Bönisch H, Burwinkel B, Autschbach F, Funke B, Lasitshka F, Gassler N, Fischer C, Whorwell PJ, Atkinson W, Fell C, Büchner KJ, Schmidtmann M, van der Voort I, Wisser A-S, Berg T, Rappold G, Niesler B. First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum Mol Genet 2008, 17:2967-77. 10.1093/hmg/ddn195, 18614545.
29. Melke J, Westberg L, Nilsson S, Landen M, Soderstrom H, Baghaei F, Rosmond R, Holm G, Björntorp P, Nilsso L-G, Adolfsson R, Eriksson E. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. Arch Gen Psychiatry 2003, 60:1017-23. 10.1001/archpsyc.60.10.1017, 14557147.
30. Kilpatrick LA, Labus JS, Coveleskie K, Hammer C, Rappold G, Tillisch K, Bueller JA, Suyenobu B, Jarcho JM, McRoberts JA, Niesler B, Mayer EA. The HTR3A polymorphism c.-42C > T is associated with amygdala responsiveness in patients with irritable bowel syndrome. Gastroenterology 2011, 140:1953-51.
31. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996, 66:2621-4.
32. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CK, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-31. 10.1126/science.274.5292.1527, 8929413.
33. Camilleri M, Busciglio I, Carlson P, McKinzie S, Burton D, Baxter K, Ryks M, Zinsmeister AR. Candidate genes and sensory functions in health and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2008, 295:219-25.
34. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 2005, 62:529-35. 10.1001/archpsyc.62.5.529, 15867106.
35. Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between the serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet 2004, 127:85-9.
36. van Marrewijk CJ, Mujakovic S, Fransen GA, Numans ME, de Wit NJ, Muris JW, van Oijen MG, Jansen JB, Grobbee DE, Knottnerus JA, Laheij RJ. Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trial. Lancet 2009, 373:215-25. 10.1016/S0140-6736(09)60070-2, 19150702.
37. Junghard O, Lauritsen K, Talley NJ, Wiklund IK. Validation of seven graded diary cards for severity of dyspeptic symptoms in patients with non-ulcer dyspepsia. Eur J Surg Suppl 1998, 583:106-11.
38. Arrindell WA, Ettema JHM. SCL-90. Symptom checklist. Handleiding bij een multidimensionele psychopathologie-indicator. 2003, Swets Test Publishers, Lisse.
39. Schreurs PJG, van de Willige G, van de Brosshot JF, Tellegen B, Graus GMH. De Utrechtse Coping Lijst (Utrecht Coping Questionnaire). 1993, Swets and Zeitlinger, Lisse.
40. Camilleri M, Atanasova E, Carlson PJ, Ahmad U, Kim HJ, Viramontes BE, McKinzie S, Urrutia R. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology 2002, 123:425-32. 10.1053/gast.2002.34780, 12145795.
41. Iidaka T, Ozaki N, Matsumoto A, Nogawa J, Kinoshita Y, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N. A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. J Neurosci 2005, 25:6460-6. 10.1523/JNEUROSCI.5261-04.2005, 16000636.
42. Millan MJ. Descending control of pain. Prog Neurobiol 2002, 66:355-474. 10.1016/S0301-0082(02)00009-6, 12034378.
43. Alhaider AA, Lei SZ, Wilcox GL. Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. J Neurosci 1991, 11:1881-8.
44. Danzebrink RM, Gebhart GF. Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat. Brain Res 1991, 538:64-75. 10.1016/0006-8993(91)90377-8, 2018933.
45. Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG. The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J Biol Chem 1999, 274:30799-810. 10.1074/jbc.274.43.30799, 10521471.
46. Liu MT, Rayport S, Jiang Y, Murphy DL, Gershon MD. Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol 2002, 283:1398-411.
47. McEwen BS. Invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J Applied Physiology 2001, 91:2785-801.
48. Sakai Y, Nishikawa M, Leyton M, Benkelfat C, Young SN, Diksic M. Cortical trapping of alpha-[(11)C]methyl-1-tryptophan, an index of serotonin synthesis, is lower in females than in males. Neuroimage 2006, 33:815-24. 10.1016/j.neuroimage.2006.08.004, 16996279.
49. Labus JS, Naliboff BN, Fallon J, Berman SM, Suyenobu B, Bueller JA, Mandelkern M, Mayer EA. Sex differences in brain activity during aversive visceral stimulation and its expectation in patients with chronic abdominal pain: a network analysis. Neuroimage 2008, 41:1032-43. 10.1016/j.neuroimage.2008.03.009, 3114874, 18450481.
50. Barnes NM, Hales TG, Lummis SC, Peters JA. The 5-HT3 receptor-the relationship between structure and function. Neuropharmacology 2009, 56:273-84. 10.1016/j.neuropharm.2008.08.003, 18761359.
51. Houghton LA. Evidence of abnormal rectal sensitivity in IBS. Irritable Bowel Syndrome: Diagnosis and Treatment 2002, 69-76. London: WB Saunders, Camilleri M, Spiller R.
52. de Vries D, ter Linde J, van Herwaarden M, Smout M, Samsom M. Serotonin receptor 3a polymorphism C178t is associated with visceral hypersensitivity in GERD [abstract]. Gastroenterology 2007, 132:A276.
53. Gatt JM, Williams LM, Schofield PR, Dobson-Stone C, Paul RH, Grieve SM, Clark CR, Gordon E, Nemeroff CB. Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood. Depress Anxiety 2010, 27:752-9. 10.1002/da.20726, 20694966.
54. Yamada K, Hattori E, Iwayama Y, Ohnishi T, Ohba H, Toyota T, Takao H, Minabe Y, Nakatani N, Higuchi T, Detera-Wadleigh SD, Yoshikawa T. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biol Psychiatry 2006, 60:192-201. 10.1016/j.biopsych.2005.11.008, 16487942.