Preparation of a solid-in-oil nanosuspension containing l-ascorbic acid as a novel long-term stable topical formulation

International Journal of Pharmaceutics

Volumn 420, Issue 1, 2011, Pages 156-160

  Piao, Hongyu ^a   Kamiya, Noriho ^b,c   Cui, Fude ^a   Goto, Masahiro ^b,c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Graduate School of Engineering   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Enzymatic degradation; l Ascorbic acid; Mixture surfactant systems; Solid in oil nanosuspension; Stabilization; Topical formulation

Indexed keywords

ASCORBIC ACID; SURFACTANT; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG STABILITY; ENZYMATIC DEGRADATION; PARTICLE SIZE; PRIORITY JOURNAL; SOLID IN OIL NANOSUSPENSION; SUSPENSION;

ADMINISTRATION, TOPICAL; ANTIOXIDANTS; ASCORBIC ACID; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; LIPASE; NANOPARTICLES; NANOTECHNOLOGY; OILS; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; VITAMINS;

EID: 80054709243     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.08.025     Document Type: Article

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