The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1819-1822

  Ting, Pauline C ^a   Kuang, Rongze ^a   Wu, Heping ^a   Aslanian, Robert G ^a   Cao, Jianhua ^a   Kim, David W ^a   Lee, Joe F ^a   Schwerdt, John ^a   Zhou, Gang ^a   Wainhaus, Samuel ^a   Black, Todd A ^a   Cacciapuoti, Anthony ^a   McNicholas, Paul M ^a   Xu, Yiming ^a   Walker, Scott S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Glucan synthase inhibitor

Indexed keywords

2 (3,5 DIFLUOROPHENYL) 4 (3 FLUOROCYCLOPENTYLOXY) 5 [4 ( ISOPROPYLSULFONYL)PIPERAZIN 1 YL]PYRIDAZIN 3(2H) ONE; 5 [4 ( BENZYLSULFONYL)PIPERAZIN 1 YL] 4 MORPHOLINO 2 PHENYLPYRIDAZIN 3(2H) ONE; ALKYLSULFONAMIDE DERIVATIVE; AMPHOTERICIN B; ANTIFUNGAL AGENT; BENZYLSULFONAMIDE DERIVATIVE; CASPOFUNGIN; GLUCAN SYNTHASE; ISOPROPYLSULFONAMIDE DERIVATIVE; METHYLCELLULOSE; PYRIDAZINONE DERIVATIVE; PYRIDINE DERIVATIVE; SULFONAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; AREA UNDER THE CURVE; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDIASIS; DRUG ABSORPTION; DRUG CLEARANCE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG SYNTHESIS; FUNGUS GROWTH; GROWTH INHIBITION; HUMAN; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; GLUCOSYLTRANSFERASES; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA GLABRATA;

EID: 79952361638     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.058     Document Type: Article

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