COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells

Biochemical Pharmacology

Volumn 82, Issue 10, 2011, Pages 1277-1290

  Cerella, Claudia ^a   Sobolewski, Cyril ^a   Chateauvieux, Sébastien ^a   Henry, Estelle ^a   Schnekenburger, Michael ^a   Ghelfi, Jenny ^a   Dicato, Mario ^b   Diederich, Marc ^a  

^a LABORATOIRE DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE DU CANCER   (Luxembourg)

^b Centre Hospitalier   (Luxembourg)

Author keywords

Celecoxib; Chemoresistance; Mitochondrial pathway; Nimesulide; NS 398

Indexed keywords

2,5 DIMETHYL CELECOXIB; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ETOPOSIDE; FAS LIGAND; HYDROGEN PEROXIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; PROSTAGLANDIN; PROTEIN BAK; PROTEIN BAX; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; 2,5 DIMETHYLCELECOXIB; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CASPASE 3; CASPASE 9; CISPLATIN; CYTARABINE; CYTOCHROME C; DOXORUBICIN; FAS ANTIBODY; HISTONE H2AX; IRINOTECAN; METHOTREXATE; PROSTAGLANDIN E2; PUROMYCIN;

APOPTOSIS; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DRUG ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRESS; ANTINEOPLASTIC ACTIVITY; CANCER CELL; CANCER MODEL; CANCER RESISTANCE; CELL STRESS; CONCENTRATION RESPONSE; DRUG ACCUMULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG SENSITIVITY; DRUG TRANSPORT; INTERNALIZATION; INTRACELLULAR SIGNALING; PROSTAGLANDIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CYCLOOXYGENASE 2 INHIBITORS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOLOGIC NEOPLASMS; HUMANS; K562 CELLS; NITROBENZENES; PYRAZOLES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; SULFONAMIDES; U937 CELLS;

EID: 80054678996     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.06.028     Document Type: Conference Paper

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