Transcriptional profiling of melanoma as a potential predictive biomarker for response to immunotherapy

Immunologic Signatures of Rejection

Volumn , Issue , 2011, Pages 229-238

  Gajewski, Thomas F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80054113020     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-7219-4_15     Document Type: Chapter

References (35)

1. Appay, V., Jandus, C., Voelter, V. Reynard, S., Coupland, S. E., Rimoldi, D., Lienard, D., Guillaume, P., Krieg, A. M., Cerottini, J. C., et al. (2006). New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol 177, 1670-1678.
2. Atkins, M. B., Lotze, M. T., Dutcher, J. P., Fisher, R. I., Weiss, G., Margolin, K., Abrams, J., Sznol, M., Parkinson, D., Hawkins, M., et al. (1999). High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 17, 2105-2116.
3. Banchereau, J., Palucka, A. K., Dhodapkar, M., Burkeholder, S., Taquet, N., Rolland, A., Taquet, S., Coquery, S., Wittkowski, K. M., Bhardwaj, N., et al. (2001). Immune and clinical responses in patients with metastatic melanoma to CD34 (+) progenitor-derived dendritic cell vaccine. Cancer Res 61, 6451-6458.
4. Baumgaertner, P. Rufer, N., Devevre, E., Derre, L., Rimoldi, D., Geldhof, C., Voelter, V. Lienard, D., Romero, P., and Speiser, D. E. (2006). Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens. Cancer Res 66, 1912-1916.
5. Blank, C., Brown, I., Peterson, A. C., Spiotto, M., Iwai, Y. Honjo, T., and Gajewski, T. F. (2004). PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 64, 1140-1145.
6. Brown, I. E., Blank, C., Kline, J., Kacha, A. K., and Gajewski, T. F. (2006). Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection. J Immunol 177, 4521-4529.
7. Cormier, J. N., Salgaller, M. L., Prevette, T., Barracchini, K. C., Rivoltini, L., Restifo, N. P. Rosenberg, S. A., and Marincola, F. M. (1997). Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A [see comments]. Cancer J Sci Am 3, 37-44.
8. Dong, H., and Chen, L. (2003). B7-H1 pathway and its role in the evasion of tumor immunity. J Mol Med 81, 281-287.
9. Gajewski, T. F. (2007). Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment. Clin Cancer Res 13, 5256-5261.
10. Gajewski, T. F., Meng, Y. Blank, C., Brown, I., Kacha, A., Kline, J., and Harlin, H. (2006). Immune resistance orchestrated by the tumor microenvironment. Immunol Rev 213, 131-145.
11. Gajewski, T. F., Zha, Y., Thurner, B., and Schuler, G. (2009). Association of gene expression profile in melanoma and survival to a dendritic cell-based vaccine. J Clin Oncol 27, 9002.
12. Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pages, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006). Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964.
13. Guilloux, Y., Lucas, S., Brichard, V. G., Van Pel, A., Viret, C., De Plaen, E., Brasseur, F., Lethe, B., Jotereau, F., and Boon, T. (1996). A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene. J Exp Med 183, 1173-1183.
14. Hamid, O., Chasalow, S. D., Tsuchihashi, Z., Alaparthy, S., Galbraith, S., and Berman, D. (2009). Association of baseline and on-study tumor biopsy markers with clinical activity in patients with advanced melanoma treated with ipilimumab. J Clin Oncol 27
15. Harlin, H., Kuna, T. V. Peterson, A. C., Meng, Y. and Gajewski, T. F. (2006). Tumor progression despite massive influx of activated CD8 (+) T cells in a patient with malignant melanoma ascites. Cancer Immunol Immunother 55, 1185-1197.
16. Harlin, H., Meng, Y. Peterson, A. C., Zha, Y. Tretiakova, M., Slingluff, C., McKee, M., and Gajewski, T. F. (2009). Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res 69, 3077-3085.
17. Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008). Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 322, 1097-1100.
18. Jager, E., Chen, Y. T., Drijfhout, J. W., Karbach, J., Ringhoffer, M., Jager, D., Arand, M., Wada, H., Noguchi, Y. Stockert, E., et al. (1998). Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med 187, 265-270.
19. Jiang, X., Zhou, J., Yuen, N. K., Corless, C. L., Heinrich, M. C., Fletcher, J. A., Demetri, G. D., Widlund, H. R., Fisher, D. E., and Hodi, F. S. (2008). Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res 14, 7726-7732.
20. Kline, J., Brown, I. E., Zha, Y. Y., Blank, C., Strickler, J., Wouters, H., Zhang, L., and Gajewski, T. F. (2008). Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma. Clin Cancer Res 14, 3156-3167.
21. Louahed, J., Gruselle, O., Gaulis, S., Coche, T., Eggermont, A. M., Kruit, W., Dreno, B., Charion Sileni, V., Lehmann, F., and Brichard, V. G. (2008). Expression of defined genes identified by pre-treatment tumor profiling: association with clinical responses to the GSK MAGE-A3 immunotherapeutic in metastatic melanoma patients. J Clin Oncol 26
22. Mellor, A. L., Sivakumar, J., Chandler, P., Smith, K., Molina, H., Mao, D., and Munn, D. H. (2001). Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat Immunol 2, 64-68.
23. Mortarini, R., Piris, A., Maurichi, A., Molla, A., Bersani, I., Bono, A., Bartoli, C., Santinami, M., Lombardo, C., Ravagnani, F., et al. (2003). Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma. Cancer Res 63, 2535-2545.
24. Nomura, T., and Sakaguchi, S. (2005). Naturally arising CD25+CD4+ regulatory T cells in tumor immunity. Curr Top Microbiol Immunol 293, 287-302.
25. Peterson, A. C., Harlin, H., and Gajewski, T. F. (2003). Immunization with Melan-A peptidepulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J Clin Oncol 21, 2342-2348.
26. Restifo, N. P., and Rosenberg, S. A. (1999). Developing recombinant and synthetic vaccines for the treatment of melanoma. Curr Opin Oncol 11, 50-57.
27. Richards, J. M., Gilewski, T. A., Ramming, K., Mitchel, B., Doane, L. L., and Vogelzang, N. J. (1992). Effective chemotherapy for melanoma after treatment with interleukin-2. Cancer 69, 427-429.
28. Rosenberg, S. A., Zhai, Y., Yang, J. C., Schwartzentruber, D. J., Hwu, P., Marincola, F. M., Topalian, S. L., Restifo, N. P., Seipp, C. A., Einhorn, J. H., et al. (1998). Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens. J Natl Cancer Inst 90, 1894-1900.
29. Schwartz, R. H. (1997). T cell clonal anergy. Curr Opin Immunol 9, 351-357.
30. Smalley, K. S., and Flaherty, K. T. (2009). Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment. Future Oncol 5, 775-778.
31. Sullivan, R. J., Hoshida, Y. Brunet, J., Tahan, S., Aldridge, J., Kwabi, C., Gardiner, E., McDermot, D., Golub, T., and Atkins, M. A. (2009). A single center experience with high-dose IL-2 treatment for patients with advanced melanoma and pilot investigation of a novel gene expression signature as a predictor of response. J Clin Oncol 27
32. Uyttenhove, C., Pilotte, L., Theate, I., Stroobant, V. Colau, D., Parmentier, N., Boon, T., and Van Den Eynde, B. J. (2003). Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase. Nat Med 9, 1269-1274.
33. Van Der Bruggen, P., Bastin, J., Gajewski, T., Coulie, P. G., Boel, P., De Smet, C., Traversari, C., Townsend, A., and Boon, T. (1994). A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. Eur J Immunol 24, 3038-3043.
34. Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003). Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348, 203-213.
35. Zhang, L., Gajewski, T. F., and Kline, J. (2009). PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood 114, 1545-1552.