Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects

Neuropharmacology

Volumn 62, Issue 1, 2012, Pages 347-357

  Nilsson, Anna ^a   Stroth, Nikolas ^b   Zhang, Xiaoqun ^b   Qi, Hongshi ^b   Fälth, Maria ^a   Sköld, Karl ^a   Hoyer, Daniel ^c   Andrén, Per E ^a   Svenningsson, Per ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antidepressants; Depression; Hypothalamus; Peptidomics; Somatostatin; SRIF

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CEREBELLIN; CEREBELLIN 1; CEREBELLIN 2; CEREBELLIN 4; CEREBELLIN PRECURSOR; CHROMOGRANIN B; GLUTAMATE RECEPTOR 1; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; IMIPRAMINE; L 803807; LEUCINE ENKEPHALIN; MELANOTROPIN ALPHA; MESSENGER RNA; METENKEPHALIN; N [3 (AMINOMETHYL)CYCLOHEXYLMETHYL] 3 (1H INDOL 3 YL) 2 [(SPIRO[1H INDENE 1,4' PIPERIDIN] 1' YLCARBONYL)AMINO]PROPIONAMIDE; NEUROPEPTIDE; PEPTIDE SRIF 14; PEPTIDE SRIF 28; PEPTIDOMIMETIC AGENT; SECRETOGRANIN II; SECRETOGRANIN PRECURSOR; SOMATOSTATIN; SOMATOSTATIN 1 AUTORECEPTOR ANTAGONIST; SRA 880; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT EFFECT; BRAIN CORTEX; BRAIN SLICE; CEREBELLIN 1 GENE; CEREBELLIN 2 GENE; CEREBELLIN 4 GENE; CHRONIC DRUG ADMINISTRATION; CONFERENCE PAPER; CONTROLLED STUDY; DENTATE GYRUS; DOWN REGULATION; DRUG ACTIVITY; EXPERIMENTAL TEST; GENE; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HYPOTHALAMUS; LOCOMOTION; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SECRETOGRANIN 2 GENE; SOMATOSTATIN GENE; TAIL SUSPENSION TEST; TREATMENT DURATION; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CEREBRAL CORTEX; CHROMOGRANIN B; GENE EXPRESSION REGULATION; HINDLIMB SUSPENSION; HYPOTHALAMUS; IMIPRAMINE; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEUROPEPTIDES; PHOSPHORYLATION; PIPERAZINES; PROTEIN PRECURSORS; QUINOLINES; SOMATOSTATIN; SOMATOSTATIN-28; TIME FACTORS;

EID: 80054111781     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.08.004     Document Type: Conference Paper

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