CPUYJ039, a newly synthesized benzimidazole-based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 11, 2011, Pages 1462-1469

  Jiang, Cheng ^a,b   Yang, Lei ^c   Wu, Wu Tong ^c   Guo, Qing Long ^a   You, Qi Dong ^a,b  

^a Jiangsu Key Laboratory of Carcinogenesis and Intervention   (China)

^b Department of Medicinal Chemistry ^*  (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

antitumor; apoptosis; cell cycle; HCT116 cells; KSP inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; CPUYJ 039; DNA; KINESIN; KINESIN SPINDLE PROTEIN; LIPOCORTIN 5; MALACHITE GREEN; MONASTROL; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATASES; ANTIMITOTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZIMIDAZOLES; BLOTTING, WESTERN; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HCT116 CELLS; HUMANS; KINESIN; MICROTUBULES; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS;

EID: 80054106580     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01350.x     Document Type: Article

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