Viral genome DNA/lipoplexes elicit in situ oncolytic viral replication and potent antitumor efficacy via systemic delivery

Journal of Controlled Release

Volumn 155, Issue 2, 2011, Pages 317-325

  Kwon, Oh Joon ^a   Kang, Eunah ^a   Kim, Sungwan ^c   Yun, Chae Ok ^a,b  

^a Yonsei University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

Ad genome lipoplex; Oncolytic adenovirus; Orthotopic lung tumor model; Systemic delivery

Indexed keywords

ALTERNATIVE APPROACH; ANTI-TUMOR EFFICACY; ANTI-TUMORS; AVERAGE DIAMETER; BIODISTRIBUTIONS; BLOOD CIRCULATION; CATIONIC LIPOSOMES; HEPATOTOXICITY; IMMUNOHISTOCHEMICAL ANALYSIS; IN-SITU; IN-VIVO; INNATE IMMUNE RESPONSE; LIPOPLEXES; LUNG CANCER; METASTATIC TUMORS; NEUTRALIZING ANTIBODIES; ONCOLYTIC ADENOVIRUS; ORTHOTOPIC; PHOSPHATE-BUFFERED SALINES; SYSTEMIC ADMINISTRATION; SYSTEMIC DELIVERY; THERAPEUTIC GENES; TUMOR NECROSIS; TUMOR TISSUES; TUMOR VOLUMES; VIRAL GENOME; VIRAL REPLICATION; VIROTHERAPY; LUNG TUMOR;

ANTIBODIES; BIOLOGICAL ORGANS; CARDIOVASCULAR SYSTEM; CELL DEATH; DISEASES; DNA; ENZYME INHIBITION; GENE THERAPY; LIPOSOMES; MAMMALS; PHOSPHOLIPIDS; POLYMERASE CHAIN REACTION; TUMORS;

TUMORS; GENES;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ANTINEOPLASTIC AGENT; PMT D19; UNCLASSIFIED DRUG; VIRUS DNA; LIPOPLEX; NEUTRALIZING ANTIBODY; PHOSPHATE BUFFERED SALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN VIVO CULTURE; LUNG CANCER; MALE; MOUSE; NONHUMAN; ONCOLYTIC VIROTHERAPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR VOLUME; VIRUS GENOME; VIRUS REPLICATION; ADENOVIRUS; ANIMAL CELL; APOPTOSIS; CANCER GENE THERAPY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; IN VIVO STUDY; INNATE IMMUNITY; VIRUS GENE;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ANIMALS; APOPTOSIS; CELL SURVIVAL; CYTOKINES; CYTOPATHOGENIC EFFECT, VIRAL; DRUG CARRIERS; FATTY ACIDS, MONOUNSATURATED; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GENOME, VIRAL; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; PHOSPHATIDYLETHANOLAMINES; QUATERNARY AMMONIUM COMPOUNDS; REAL-TIME POLYMERASE CHAIN REACTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; VIRUS REPLICATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80054102626     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.06.014     Document Type: Conference Paper

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