RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration

Biochemical and Biophysical Research Communications

Volumn 414, Issue 1, 2011, Pages 181-185

  Huang, Yongsheng ^a,b   Yang, Yang ^a   Gao, Rui ^a   Yang, Xianmei ^a   Yan, Xiaohua ^b   Wang, Chenji ^a   Jiang, Sirui ^a   Yu, Long ^a  

^a FUDAN UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

Cell migration; RLIM; Smurf2; TGF

Indexed keywords

BINDING PROTEIN; PROTEIN SMURF2; RING FINGER LIM DOMAIN BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

CELL LINE, TUMOR; CELL MOVEMENT; CHROMATIN IMMUNOPRECIPITATION; HUMANS; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN-PROTEIN LIGASES;

EID: 80054073802     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.053     Document Type: Article

References (20)

1. Derynck Rik, Zhang Ying E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003, 425:577-584.
2. Heldin C.H., Miyazono K., ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390:465-471.
3. Shi Y., Massagué J. Mechanisms of TGF-beta signalling from cell membrane to the nucleus. Cell 2003, 113:685-700.
4. Bonni S., Wang H.-R., Causing C.G., Kavsak P., Stroschein S.L., Luo K., Wrana J.L. TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 2001, 3:587-595.
5. Izzi L., Attisano L. Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene 2004, 23:2071-2078.
6. Massague J. TGFbeta in cancer. Cell 2008, 134:215-230.
7. Adorno M., Cordenonsi M., Montagner M., Dupont S., Wong C., Hann B., Solari A., Bobisse S., Rondina M.B., Guzzardo V., Parenti A.R., Rosato A., Bicciato S., Balmain A., Piccolo S. A Mutant-p53/Smad complex opposes p63 to empower TGF beta-induced metastasis. Cell 2009, 137:87-98.
8. Ostendorff H.P., Peirano R.I., Peters M.A., Schlüter A., Bossenz M., Scheffner M., Bach I. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature 2002, 416:99-103.
9. Bach I., Rodriguez-Esteban C., Carrière C., Bhushan A., Krones A., Rose D.W., Glass C.K., Andersen B., Izpisúa Belmonte J.C., Rosenfeld M.G. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 1999, 22:394-399.
10. Yan X., Chen Y.G. Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling. Biochem. J. 2011, 434:1-10.
11. Jonkers I., Barakat T.S., Achame E.M., Monkhorst K., Kenter A., Rentmeester E., Grosveld F., Grootegoed J.A., Gribnau J. RNF12 is an X-encoded dose-dependent activator of X chromosome inactivation. Cell 2009, 139:999-1011.
12. Shin J., Bossenz M., Chung Y., Ma H., Byron M., Taniguchi-Ishigaki N., Zhu X., Jiao B., Hall L.L., Green M.R., Jones S.N., Hermans-Borgmeyer I., Lawrence J.B., Bach I. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature 2010, 467:977-981.
13. Barakat T.S., Gunhanlar N., Pardo C.G., Achame E.M., Ghazvini M., Boers R., Kenter A., Rentmeester E., Grootegoed J.A., Gribnau J. RNF12 activates Xist and is essential for X chromosome inactivation. PLoS Genet. 2011, 7:e1002001.
14. Hiratani I., Yamamoto N., Mochizuki T., Ohmori S.Y., Taira M. Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions. Development 2003, 130:4161-4175.
15. Ostendorff H.P., Tursun B., Cornils K., Schlüter A., Drung A., Güngör C., Bach I. Dynamic expression of LIM cofactors in the developing mouse neural tube. Dev. Dyn. 2006, 235:786-791.
16. Her Y.R., Chung I.K. Ubiquitin ligase RLIM modulates telomere length homeostasis through a proteolysis of TRF1. J. Biol. Chem. 2009, 284:8557-8566.
17. Johnsen S.A., Güngör C., Prenzel T., Riethdorf S., Riethdorf L., Taniguchi-Ishigaki N., Rau T., Tursun B., Furlow J.D., Sauter G., Scheffner M., Pantel K., Gannon F., Bach I. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res. 2009, 69:128-136.
18. Fukunaga E., Inoue Y., Komiya S., Horiguchi K., Goto K., Saitoh M., Miyazawa K., Koinuma D., Hanyu A., Imamura T. Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. J. Biol. Chem. 2008, 283:35660-35667.
19. Oft M., Akhurst R.J., Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat. Cell Biol. 2002, 4:487-494.
20. Tian F., DaCosta Byfield S., Parks W.T., Yoo S., Felici A., Tang B., Piek E., Wakefield L.M., Roberts A.B. Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res. 2003, 63:8284-8292.