Standardizing procedures to study sensitization of human spinal nociceptive processes: Comparing parameters for temporal summation of the nociceptive flexion reflex (TS-NFR)

International Journal of Psychophysiology

Volumn 81, Issue 3, 2011, Pages 263-274

  Terry, Ellen L ^a   France, Christopher R ^b   Bartley, Emily J ^a   DelVentura, Jennifer L ^a   Kerr, Kara L ^a   Vincent, Ashley L ^a   Rhudy, Jamie L ^a  

^a UNIVERSITY OF TULSA   (United States)

^b OHIO UNIVERSITY   (United States)

Author keywords

Electric stimulation; Electromyogram; Nociception; Pain; Pain modulation; Plasticity; RIII reflex; Spinal cord

Indexed keywords

ADULT; ARTICLE; ELECTROMYOGRAM; ELECTROSTIMULATION; EVOKED SOMATOSENSORY RESPONSE; FEMALE; FLEXOR REFLEX; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE TONE; NOCICEPTION; NOCICEPTIVE FLEXION REFLEX; NORMAL HUMAN; SCORING SYSTEM; SENSITIZATION; SPINAL CORD; SPINAL NOCICEPTION; STIMULUS RESPONSE; TEMPORAL SUMMATION;

DATA INTERPRETATION, STATISTICAL; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEMALE; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NOCICEPTION; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; REFLEX; SKIN; SPINAL CORD; TIME FACTORS; YOUNG ADULT;

EID: 80054036148     PISSN: 01678760     EISSN: 18727697     Source Type: Journal    
DOI: 10.1016/j.ijpsycho.2011.06.021     Document Type: Article

References (48)

1. Alexander D.M., Trengove C., Johston P., Cooper T., August J.P., Gordon E. Separating individual skin conductance responses in a short interstimulus-interval paradigm. J. Neurosci. Methods 2005, 146:116-123.
2. Andersen O.K., Spaich E.G., Madeleine P., Arendt-Nielsen L. Gradual enlargement of human withdrawal reflex receptive fields following repetitive painful stimulation. Brain Res. 2005, 1042:194-204.
3. Arendt-Nielsen L., Graven-Nielsen T. Central sensitization in fibromyalgia and other musculoskeletal disorders. Current Pain and Headache Reports 2003, 7:355-361.
4. Arendt-Nielsen L., Brennum J., Sindrup S., Bak P. Electrophysiological and psychophysical qunatification of temporal summation in the human nociceptive system. European Journal of Applied Physiology 1994, 68:266-273.
5. Arendt-Nielsen L., Petersen-Felix S., Fischer M., Bak P., Bjerring P., Zbinden A.M. The effect of N-methyl-d-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo controlled experimental human study. Anesthesia and Analgesia 1995, 81:63-68.
6. Arendt-Nielsen L., Sonnenborg F.A., Andersen O.K. Facilitation of the withdrawal reflex by repeated transcutaneous electrical stimulation: an experimental study of central integration in humans. European Journal of Applied Physiology 2000, 81:165-173.
7. Aslaksen P.M., Myrbakk I.N., Hoifodt R.S., Flaten M.A. The effect of experimenter gender on autonomic and subjective responses to pain stimuli. Pain 2007, 129:260-268.
8. Banic B., Petersen-Felix S., Andersen O.K., Radanov B.P., Villiger P.M., Arendt-Nielsen L., Curatolo M. Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain 2004, 107:7-15.
9. Bendtsen L. Central sensitization in tension-type headache-possible pathophysiological mechanisms. Cephalalgia: An International Journal Of Headache 2000, 20:486.
10. Chan C.W., Dallaire M. Subjective pain sensation is linearly correlated with the flexion reflex in man. Brain Res. 1989, 479:145-150.
11. Chan C.W., Tsang H.H.Y. A quantitative study of flexion reflex in man: relevance to pain research. Advances in Pain Research and Therapy 1985, 9:361-369.
12. Davies S.N., Lodge D. Evidence for involvement of N-methyl-d-aspartate receptors in 'wind-up' of class 2 neurons in the dorsal horn of the rate. Brain Res. 1987, 424:402-406.
13. Desmedt J.E., Godaux E. Habituation of exteroceptive suppression and of exteroceptive reflexes in man as influenced by voluntary contraction. Brain Res. 1976, 106:21.
14. Desmeules J.A., Cedraschi C., Rapiti E., Baumgartner E., Finckh A., Cohen P., Dayer P., Vischer T.L. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis Rheum. 2003, 48:1420.
15. Dowman R. Spinal and supraspinal correlates of nociception in man. Pain 1991, 45:269-281.
16. Dowman R. Possible startle response contamination of the spinal nociceptive withdrawal reflex. Pain 1992, 49:187-197.
17. Eide P.K. Wind-up and the NMDA receptor complex from a clinical perspective. European Journal of Pain 2000, 4:5-15.
18. Farrell M., Gibson S. Age interacts with stimulus frequency in the temporal summation of pain. Pain Medicine 2007, 8:514-520.
19. France C.R., France J.L., Ring C., McIntyre D. Catastrophizing is related to pain ratings, but not nociceptive flexion reflex threshold. Pain 2002, 99:459-463.
20. France C.R., Froese S.A., Stewart J.C. Altered central nervous system processing of noxious stimuli contributes to decreased nociceptive responding in individuals at risk for hypertension. Pain 2002, 98:101-108.
21. France C.R., Keefe F.J., Emery C.F., Affleck G., France J.L., Waters S., Caldwell D.S., Stainbrook D., Hackshaw K.V., Edwards C. Laboratory pain perception and clinical pain in post-menopausal women and age-matched men with osteoarthritis: relationship to pain coping and hormonal status. Pain 2004, 112:274-281.
22. France C.R., Rhudy J.L., McGlone S. Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: further evaluation of standardized scoring criteria. Pain 2009, 145:211-218.
23. Graven-Nielsen T., Aspegren Kendall S., Henriksson K.G., Bengtsson M., Sorensen J., Johnson A., Gerdle B., Arendt-Nielsen L. Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain 2000, 85:483.
24. Guirimand F., Dupont X., Brasseur L., Chauvin M., Bouhassira D. The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans. Anesth. Analg. 2000, 90:408-414.
25. Hugon M. Exteroceptive reflexes to stimulation of the sural nerve in normal man. New Developments in Electromyography and Clinical Neurophysiology 1973, 713-729. Karger, Basel. J.E. Desmedt (Ed.).
26. Li J., Simone D., Larson A. Windup leads to characteristics of central sensitization. Pain 1999, 79:75-82.
27. Maxwell S.E. The persistence of underpowered studies in psychological research: causes, consequences, and remedies. Psychological Methods 2004, 9:147-163.
28. Mendell L.M. Physiological properties of unmyelinated fibre projection to the spinal cord. Expermental Neurology 1966, 16:316-332.
29. Mendell L.M., Wall P.D. Responses of single dorsal cord cells to peripheral cutaneous unmyelinated fibres. Nature 1965, 206:97-99.
30. Price D.D. Characteristics of second pain and flexion reflexes indicative of prolonged central summation. Experimental Neurology 1972, 37:57-68.
31. Price D.D., Staud R. Neurobiology of fibromyalgia syndrome. The Journal of Rheumatology. 2005, 75:22-28.
32. Price D.D., Hull C.D., Buschwald N.A. Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli. Exp. Neurol. 1971, 33:291-309.
33. Price D.D., Hu J.W., Dubner R., Gracely R.H. Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses. Pain 1977, 3:57-68.
34. Rhudy J.L., France C.R. Defining the nociceptive flexion reflex (NFR) threshold in human participants: a comparison of different scoring criteria. Pain 2007, 128:244-253.
35. Rhudy J.L., Williams A.E., McCabe K., Nguyen M.A., Rambo P. Affective modulation of nociception at spinal and supraspinal levels. Psychophysiol. 2005, 42:579-587.
36. Rhudy J.L., Maynard L.J., Russell J.L. Does in-vivo catastrophizing engage descending modulation of spinal nociception?. J Pain 2007, 8:325-333.
37. Rhudy J.L., Arnau R.C., Green B.A., France C.R. Taxometric analysis of biceps femoris EMG following electrocutaneous stimulation over the sural nerve: determining the latent structure of the nociceptive flexion reflex (NFR). Int. J. Psychophysiol. 2008, 69:18-26.
38. Rhudy J.L., France C.R., Bartley E.J., McCabe K.M., Williams A.E. Psychophysiological responses to pain: further validation of the nociceptive flexion reflex (NFR) as a measure of nociception using multilevel modeling. Psychophysiol. 2009, 46:939-948.
39. Rhudy J.L., France C.R., Bartley E.J., Williams A.E., McCabe K.M., Russell J.L. Does pain catastrophizing moderate the relationship between spinal nociceptive processes and pain sensitivity?. The Journal of Pain 2009, 10:860-869.
40. Sandrini G., Serrao M., Rossi P., Romaniello A., Cruccu G., Willer J.C. The lower limb flexion reflex in humans. Prog. Neurobiol. 2005, 77:353-395.
41. Serrao M., Rossi P., Sandrini G., Parisi L., Amabile G.A., Nappi G., Pierelli F. Effects of diffuse noxious inhibitory controls on temporal summation of the RIII reflex in humans. Pain 2004, 112:353-360.
42. Skljarevski V., Ramadan N.M. The nociceptive flexion reflex in humans - review article. Pain 2002, 96:3-8.
43. Staud R., Price D.D., Fillingim R.B. Advanced continuous-contact heat pulse design for efficient temporal summation of second pain (windup). The Journal Of Pain 2006, 7:575-582.
44. Verne G.N., Price D.D. Irritable bowel syndrome as a common precipitant of central sensitization. Current Rheumatology Reports 2002, 4:322-328.
45. Willer J.C. Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 1977, 3:69-80.
46. Woolf C.J. Evidence for a central component of post-injury pain hypersensitivity. Nature 1983, 306:686-688.
47. You H.J., Dahl Morch C., Chen J., Arendt-Nielsen L. Simultaneous recordings of wind-up of paired spinal dorsal horn nociceptive neuron and nociceptive flexion reflex in rats. Brain Res. 2003, 960:235-245.
48. You H.J., Morch C.D., Arendt-Nielsen L. Electrophysiological characterization of facilitated spinal withdrawal reflex to repetitive electrical stimuli and its modulation by central glutamate receptor in spinal anesthetized rats. Brain Res. 2004, 1009:110-119.